Northwestern University

Lithium chloride in vitro treatment shows potential to rescue the neuronal phenotype caused by WDFY3 haploinsufficiency

We provide a comprehensive phenotypic characterization of loss-of-function (LoF) variants in WDFY3 based on the largest cohort reported to date (n = 32). Our findings define a monogenic disorder marked by neuropsychiatric features (including autism and ADHD), mild to moderate neu...

Research support networks for substance use translational research: a qualitative evaluation of the HEAL data to action (HD2A) program

Abstract Background NIH-funded research has been increasingly conducted in collaborative consortia of investigators with the support of coordinating centers. However, the extent to which such initiatives help to accomplish NIH goals and objectives with respect to the translation...

Maternal and Fetal Outcomes in Mice Following Exposure to Dolutegravir Alone or in Combination with Lamivudine or Tenofovir Disoproxil Fumarate/Emtricitabine

Abstract Background and Aims Dolutegravir (DTG)-based regimens are widely used in HIV treatment, including during pregnancy, but the contribution of the nucleoside reverse transcriptase inhibitor (NRTI) backbone on maternal and foetal outcomes remains unclear. We examined this in...

PD GENEration: an international Parkinson’s disease genetic research study

Abstract Background PD GENEration (NCT04057794, NCT04994015), sponsored by the Parkinson's Foundation in partnership with Aligning Science Across Parkinson’s (ASAP) through the Global Parkinson’s Genetics Program (GP2), is an international, observational, clinical research study...

Efficacy and Safety of Risankizumab in Paediatric Patients With Psoriasis in the OptIMMize-1 Phase III Study.

BACKGROUND: Treatment options for paediatric patients with psoriasis are limited, and additional, more advanced therapies are needed. Risankizumab is an interleukin-23 inhibitor approved to treat moderate-to-severe psoriasis in adults. OBJECTIVES: To evaluate efficacy and safety...

Grain boundary complexions stabilize Mg3Sb2-based thermoelectric devices with superior performance

Grain boundary complexions stabilize Mg 3 Sb 2 -based thermoelectric devices with superior performanceGraphical abstract Highlights • Ga-rich grain boundary complexions block Mg-diffusion channels • Mg 3 Sb 2 materials stabilize at 718 K for over 80 h• Single-leg device shows 13....

Three Strategies to Strengthen Therapist Follow-Through in Therapy Sessions: Examination of Accountability in Clinical Supervision

Abstract Clinical supervision is a natural opportunity for promoting therapist use of clinical practices supported by research in community mental health services. However, the research on thespecific strategies in supervision that are likely to have a positive impact is limited....

Development and feasibility testing of an electronic medical record intervention to improve emergency department discharge communication for patients with uncertainty: a pilot study

Abstract Background A significant proportion of patients leave the emergency department (ED) without a definitive diagnosis, leading to challenges in the post-discharge period due to diagnostic uncertainty. Building on previous work aimed at improving discharge communication, we...

Reviewing RVUs: Relevant Billing Codes for Infectious Diseases Clinicians

Caitlin Naureckas Li, Joyce Cast, Sameer Patel, Taylor Heald-Sargent, Kathleen Murtagh, Ravi Jhaveri; Reviewing RVUs: Relevant Billing Codes for Infectious

Safety and Efficacy of Left Atrial Ablation After Percutaneous Left Atrial Appendage Occlusion in High-Bleeding-Risk Patients with Atrial Fibrillation: A Multicenter Analysis from the PROCEED-AF Ablation Registry

BACKGROUND AND AIMS: Patients with left atrial appendage (LAAO) devices are increasingly referred for AF ablation, yet anticoagulation strategies remain uncertain. The goal of this study was to evaluate the safety and efficacy of catheter ablation for atrial fibrillation (AF) in...

Photochemical Oxygen‐Atom‐Transfer Reactivity of Platinum(II) Peroxycarbonates

ABSTRACT Peroxycarbonate (CO 4 2– ) is implicated in various biological, catalytic, and energy storage processes – despite the capability of transition metals to guide the reactivity of this unstable intermediate toward productive ends, the coordination chemistry of metal–peroxyc...

Barriers to Implementing the 2022 Clinical Practice Guidelines for Neonatal Hyperbilirubinemia

OBJECTIVE: To assess whether anticipated weekend follow-up and/or bilirubin rate of rise (ROR) were associated with subthreshold phototherapy (STP) following implementation of the 2022 American Academy of Pediatrics clinical practice guidelines (CPG). PATIENTS AND METHODS: A retr...

Evaluation of the Quality and Guideline Adherence of YouTube Videos on Neonatal Fever: Development and Validation of the Newborn Fever Safety and Quality Score (NFSQS)

Objective: To develop and validate the Newborn Fever Safety and Quality Score (NFSQS), a content-specific instrument for evaluating the quality and guideline adherence of Turkish-language YouTube videos on neonatal fever.Materials and Methods: An initial pool of 18 candidate item...

Diffusion Anisotropy Predicts Directional Progression After Complete Resection of Frontal Glioblastoma

BACKGROUND AND OBJECTIVES: Despite complete resection of contrast-enhancing tumor, glioblastoma frequently progresses due to microscopic invasion beyond surgical margins. In frontal glioblastoma, functional tolerance of anterior and lateral regions enables consideration of supram...

Black Women’s Health Futures: Speculative Method as Structural Intervention

Public health research predominantly works in the present tense. It documents the disparities that structural racism and gendered racism produce and projects them forward, modeling futures as extrapolations of present harm. For Black women, positioned at the intersection of racis...

Permissible presupposition

When is it proper or acceptable for a speaker to presuppose a proposition in the course of performing a speech act? Taking Stalnaker's common ground model as my background, I argue that this is best framed as a matter of the conversational permissibility of the speaker's presuppo...

Alkoxyethyl Acetate Electrolytes for High‐Voltage Lithium Metal Batteries

High-energy-density lithium metal batteries (LMBs) require electrolytes that can simultaneously support stable lithium metal anodes and high-voltage cathodes such as NMC811 operated up to 4.5 V. Here, a molecular engineering strategy is introduced in which a carbonyl group and a...

Food for thought: a mixed methods analysis of nutrition decision making during bedside rounds in the neonatal intensive care unit

BACKGROUND: Variation in nutrition delivery contributes to poor growth in preterm infants in the neonatal intensive care unit (NICU); however, few studies have examined how clinicians develop nutrition plans. The aim of this research is to describe the nutrition decision-making p...

Alkoxyethyl Acetate Electrolytes for High‐Voltage Lithium Metal Batteries

ABSTRACT High‐energy‐density lithium metal batteries (LMBs) require electrolytes that can simultaneously support stable lithium metal anodes and high‐voltage cathodes such as NMC811 operated up to 4.5 V. Here, a molecular engineering strategy is introduced in which a carbonyl gro...

Translating etiological effect measures into medical test evaluation metrics

Abstract Traditional metrics for medical test evaluation (TE) and etiological evaluation (EE) are often analyzed within separate frameworks. We review these metrics, including recommendations to use less frequently used TE metrics. We propose a novel framework for TE by drawing f...