Northwestern University

Why translation is not enough and how functional language use can improve cultural adaptation in bilingual implementation settings

Despite widespread bilingualism, most intervention adaptation efforts remain grounded in monolingual assumptions. This approach poorly reflects how bilingual communication functions. Research in sociolinguistics and psycholinguistics shows that bilingual speakers do not “turn off...

Lessons From the Communication Bridge Trials: Advancing Meaningful Dyadic Interventions Toward Implementation

Purpose: This review describes the historical motivations, development, and evolution of the Communication Bridge (CB) research program, which is designed to maximize quality of life and minimize burden for individuals living with dementia and their communication partners. The CB...

CD248/Endosialin regulates synovial fibroblast state to control coupling of inflammation and bone damage in murine models of immune‐mediated inflammatory arthritis and ageing

Objective Synovial fibroblasts directly contribute to inflammation and damage in immune‐mediated inflammatory arthritis. CD248/Endosialin is expressed by fibroblasts in the synovium, is highly upregulated during inflammation and has been proposed as a potential therapeutic target...

The monochromatic Hahn-Wilson conjecture

Abstract We prove the $K(n)$ K ( n ) -local analogue of the Hahn-Wilson conjecture on fp-spectra, which states that the truncated Brown-Peterson spectra generate the category of fp-spectra as a thick subcategory. As a corollary, we deduce the original conjecture at height 1. Alon...

Quality standards for preclinical research in cardio-oncology

Preclinical research in cancer therapy-related cardiovascular toxicity (CTR-CVT) is a major domain of cardio-oncology and has provided biological explanation for the cardiovascular adverse effects of many cancer therapies. However, the choice of the experimental models to investi...

A Comparison of Pediatric Hospitalization Data in Cosmos and the Kids’ Inpatient Database

OBJECTIVE: To compare characteristics of pediatric hospitalizations in Epic Cosmos, an electronic health record-based database that aggregates voluntarily submitted data from across the United States, with nationally representative pediatric inpatient data in the Kids' Inpatient...

The Longitudinal Association between Gendered Racism and Disease Activity among Black Women Living with Lupus

Gendered racism, rooted in the interlocking injustices of racism and sexism, is a contributor to poor mental health; its association with physical health outcomes, however, is not well understood. This study investigates whether gendered racism is associated with disease activity...

Planning a Clinical Practice Guideline Revision for a Core Set of Outcome Measures in Adults Undergoing Neurologic Physical Therapy, Part 1: Assessing Dissemination and Scholarly Uptake

ABSTRACT Introduction Clinical Practice Guidelines (CPGs) facilitate evidence‐based decision‐making and standardising care, yet their dissemination and scholarly uptake vary widely. The Core Set of Outcome Measures for Adults With Neurologic Conditions Undergoing Rehabilitation C...

Planning a Clinical Practice Guideline Revision for a Core Set of Outcome Measures in Adults Undergoing Neurologic Physical Therapy, Part 2: Determining Stakeholders' Uptake and Recommendations

ABSTRACT Objective To determine the uptake and recommendations for revision of the 2018 Clinical Practice Guideline (CPG): Core Set Outcome Measures for Adults with Neurologic Conditions Undergoing Rehabilitation. Design Online Survey. Setting Online with participants from multip...

Best Case/Worst Case: A Multisite Randomized Trial of Scenario Planning for Patients With Late‐Stage Kidney Disease

BACKGROUND: Best Case/Worst Case (BC/WC) is a communication tool to support nephrologists and older adults with advanced chronic kidney disease with decisions about dialysis. We compared the effectiveness of training nephrologists to use BC/WC versus usual care on receipt of pall...

Development of postpartum-specific extensions to the PROMIS sleep disturbance and sleep-related impairment item banks

Abstract Background Postpartum sleep is a unique construct, and existing sleep patient-reported outcome measures (PROMs) do not adequately address some of its fundamental domains. We aimed to develop postpartum-specific extension items to the PROMIS Sleep Disturbance (SD) and Sle...

Artificial Intelligence in Echocardiography and Point-of-Care Ultrasound: Applications, Clinical Integration, and Future Directions

Artificial intelligence (AI) is increasingly used in echocardiography and point-of-care ultrasound (POCUS) to support image acquisition, view recognition, image-quality assessment, segmentation, automated quantification, disease classification, reporting, and bedside decision sup...

Hot blue progenitors of stellar-mass black holes

Abstract While the connection between massive stars and supernova explosions is well established observationally, the link between massive stars and black hole formation remains elusive. Some massive stars may collapse directly to black holes without a successful supernova, and m...

Initial Z-Drug Prescription Duration and Long-Term Use

This cohort study evaluates the association between the days’ supply of an initial Z-drug prescription and subsequent long-term use.

Impact of Omitting Observation-Status Data on Hospital Readmission Metric for Pediatric Care

OBJECTIVES: Literature from Medicare beneficiaries suggests that hospital readmission metrics limited to inpatient encounters, omitting observation-status data, may not fully capture hospital performance and affect rankings. The impact of omitting observation-status data on this...

What is the association between insulin dependence and the incidence of postoperative complications, perioperative glucose control, and five-year reoperation rates after total joint replacement?

Aims: Diabetes mellitus (DM) is associated with adverse outcomes following total hip arthroplasty (THA) and total knee arthroplasty (TKA), yet optimal perioperative risk stratification remains unclear. This study evaluated the association of insulin dependence with: 1) 90-day com...

Threatened Identity: Self Psychology Informed Communication for Serious Illness Care

Serious illness threatens both the body and the self: the coherent, continuous sense of who one is, from bodily integrity to psychosocial identity. When illness disrupts identity and patients confront mortality and dependence, a range of responses may follow, including behaviors...

Interactive Panometry: Using Proximal Balloon Distension During Functional Lumen Imaging Probe Panometry to Enhance Motility Evaluation of Inhibitory Function

Background/Aims: : Descending inhibition facilitates esophageal peristalsis and lower esophageal sphincter relaxation, processes impaired in achalasia. The functional lumen imaging probe (FLIP) assesses esophageal motility and esophagogastric junction (EGJ) opening but does not d...

Disparities in sleep-disordered breathing: epidemiology, mechanisms, and pathways toward equity– a narrative review

Purpose of review Sleep-disordered breathing (SDB), encompassing obstructive sleep apnea (OSA) and related conditions, affects tens of millions of individuals in the United States and is associated with substantial cardiovascular, metabolic, and neurocognitive morbidity. However,...

Performatives presume speaker knowledge

Abstract Performatives are declarative sentences where their use by a speaker enables the speaker to perform an additional action. This paper argues that performativity requires knowledge. The speaker must know what they say to perform the additional action. The significance of t...