Northwestern University

William Wimsatt, Donald Campbell, and the Idea of Robustness

Abstract In this paper, I chart the influence of social scientist Donald Campbell’s work on William Wimsatt’s ideas of robustness reasoning. One reason is that Campbell’s work is less familiar in the broader philosophy of science literature. Another is that Wimsatt’s famous 1981...

The Company and the Crown: Oil, Capital, and the Dual Mandate in Palestine

This article examines how the intertwined operations of empire and oil capital shaped the British Mandate in Palestine. It argues that the ‘dual Mandate’, formulated by Frederick Lugard and institutionalised through the League of Nations, should be understood not only as an ideol...

The Role of Socioeconomic Status in the Relation Between Parenting and Child Externalizing Behavior

Abstract Negative and harsh parenting strategies are associated with more child externalizing behavior, while greater parental involvement and positive reinforcement are associated with less child externalizing behavior. However, parenting strategies do not exert the same influen...

Structural stigma and LGBTQ+ youth mental health in the United States

Structural stigma, or systemic barriers to equity for minoritized populations, has been shown to have negative consequences on LGBTQ+ youth’s mental health. Most research has focused on stigma at the national or state level, limiting understanding of how local institutions and en...

Associations between substance use by type and HIV viral suppression across multiple cohorts in the US

Substance use among people with HIV (PWH) represents an important obstacle to further reductions in HIV transmission. Using data from a diverse collection of five studies including people with HIV in care and those in community cohorts, we report results for analyses of the assoc...

Long-term outcomes of prophylactic cardioprotection in early-stage breast cancer patients on non-anthracycline anti-HER2 therapy

Anti-HER2 therapy has improved survival in HER2-positive breast cancer patients for decades but is associated with well-established cardiotoxicity. Our prior randomized controlled trial PROTECT HER2 found no short-term benefit of prophylactic beta-blocker cardio protection (CPT)...

Comparative Effectiveness Research in the Americas on Penetrating Brain Injury: The COMPAS-PBI Study Protocol.

BACKGROUND AND OBJECTIVES: Penetrating brain injury (PBI) is a highly lethal form of traumatic brain injury, with substantial mortality and marked differences across high-income countries and low- to middle-income countries. The aim of the Comparative Effectiveness Research in th...

Revising the Spin and Kick Connection in Isolated Binary Black Holes

Abstract The origin of black hole (BH) spins remains one of the least understood aspects of BHs. Despite many uncertainties, it is commonly assumed that if BHs originated from isolated massive star binaries, their spins should be aligned with the orbital angular momentum of the b...

Enablers of Sustainable Pediatric Epilepsy Surgery: A Qualitative Exploration of Global Neurosurgery.

BACKGROUND AND OBJECTIVES: Of 50 million people with epilepsy globally, up to 10 million with lesional drug resistance epilepsy may be able to achieve seizure control with surgical options. Although multidisciplinary surgical care for epilepsy is available in high-income countrie...

Assessing and Addressing Frailty in Candidates for Lung Transplantation: An ISHLT Consensus Statement.

The ISHLT Consensus document for the selection of lung transplant candidates recommends frailty assessment as part of a comprehensive candidacy evaluation. Missing from this and other recent consensus documents were practical recommendations on which frailty measures to consider...

The Childhood Liver Disease Research Network's prospective characterization of pediatric primary sclerosing cholangitis.

BACKGROUND: Primary sclerosing cholangitis (PSC) is a rare biliary fibrosing disease that leads to significant morbidity and the need for liver transplantation. The Childhood Liver Disease Research Network is conducting a prospective, observational longitudinal study to define th...

Assessing the estimands and estimates of hospitalization rates in health economics and clinical medicine

Even though data on hospital admissions are widely used in health research, hospitalization‐related estimands measured using these data are not always clearly conceptualized. Consequently, estimators of these quantities can have unclear rationales and undesirable properties. We e...

Towards On-Device Evidence Gathering for Intimate Partner Infiltration: A Feasibility Study for Joint Identity-Action Detection

Intimate Partner Infiltration (IPI) refers to phone-side privacy infiltration in intimate or close relationships, often enabled by physical access to a person's smartphone and discussed in technology-facilitated Intimate Partner Violence (IPV) contexts. Unlike conventional cybera...

JWST Nebular Spectroscopy of SN 2023qov: Circumstellar Dust Emission in a Normal Type Ia Supernova

Abstract We present panchromatic observations of the Type Ia supernova (SN Ia) 2023qov, ranging from ∼2 weeks before to ∼1 yr after maximum light. JWST near- and mid-infrared spectra at +276 and +363 days show ∼400 K dust emission that cools by ∼75 K between epochs, the first una...

Patient Risk Factors for Incidental Pathology After Uterovaginal Surgery for Apical Prolapse: Systematic Review and Global Expert Consensus Statements

Abstract Introduction and Hypothesis Uterus preservation is increasingly used for uterovaginal prolapse (U-POP) repair despite ongoing concerns regarding future uterine, cervical, and adnexal pathology. We evaluated incidental pathology rates, associated risk factors, and created...

Diffusion Approximation Error for Queueing Systems with General Primitives

We investigate the steady-state diffusion-approximation error for continuous-time queueing systems with generally distributed primitives. A common picture emerges after analyzing a number of canonical systems: the error decomposes into interior and boundary terms. The former are...

Relative cyclotomic structures and equivariant complex cobordism

Abstract We describe a structure on a commutative ring (pre)cyclotomic spectrum that gives rise to a (pre)cyclotomic structure on topological Hochschild homology () relative to its underlying commutative ring spectrum. This lets us construct relative to , denoted , and we prove s...

Revealing the Proton Slingshot Mechanism in Solid Acid Electrolytes through Machine-Learning Molecular Dynamics

Abstract In solid acid electrolytes CsH2PO4 and CsHSO4, the origin of fast proton conduction has long been debated, attributed either to local proton hopping or to polyanion rotation. However, the precise role of polyanion rotation and its interplay with proton hopping remains un...

Bullous Eruption Associated With Loncastuximab Tesirine in a Patient With Diffuse Large B‐Cell Lymphoma

ABSTRACT Loncastuximab tesirine (LT) is an antibody‐drug conjugate (ADC), a novel class of therapeutics that combines a target‐specific monoclonal antibody with a cytotoxic agent via a chemical linker. LT has been approved in the United States as therapy for relapsed or refractor...

Cotranslational membrane protein biogenesis by an EMC-bound translocon

Secretory and membrane protein biogenesis occurs at ribosome-bound translocons in the endoplasmic reticulum (ER) membrane. Translocons consist of the Sec61 protein-conducting channel and various maturation factors including chaperones, modification enzymes and membrane insertases...