Harvard University

Anticancer Drugs and Cancer-Associated Thrombosis

The rapid development of novel cancer therapies has considerably improved the care of cancer patients and cancer-related survival; however, these therapies are associated with a broad range of adverse events that have become a major burden in this population. Alongside other canc...

Expanding Access to Care: Implementation of a Pediatric and Young Adult Laser Hair Removal Program for Hidradenitis Suppurativa

ABSTRACT Laser hair removal (LHR) is an effective adjunctive therapy for hidradenitis suppurativa (HS), but access is often limited by inconsistent insurance coverage. A retrospective review was conducted of 21 pediatric and young adult patients enrolled in an LHR program for HS...

Moderating effect of social support on the association between changes in financial stress and depressive and anxiety symptoms during the COVID-19 pandemic in Medicaid recipients: a longitudinal study

The COVID-19 pandemic caused financial disruption for some individuals, especially in lower-income communities. Social support has been shown to protect mental health during stressful times, but little is known about whether social support protects against financial stress. This...

Associations between substance use by type and HIV viral suppression across multiple cohorts in the US

Substance use among people with HIV (PWH) represents an important obstacle to further reductions in HIV transmission. Using data from a diverse collection of five studies including people with HIV in care and those in community cohorts, we report results for analyses of the assoc...

Young children can infer what speakers know based on their causal influence over listeners

A causal, mentalistic understanding of communication—a process by which a speaker’s mind causes a change in a listener’s mind—can support powerful inferences that go beyond observable data. If A struggles to activate a toy but succeeds after B whispers to A, you can infer that B...

The landscape of allele-specific expression in human kidneys

Allele-specific expression (ASE), the preferential expression of one gene copy, is a key mechanism of genomic regulation. However, its role in human kidney disease remains poorly understood. In this study, we generated a high-quality, genome-wide ASE map using paired whole-genome...

Setting of Alcohol Use Disorder Diagnosis Among Women Enrolled in Medicare

OBJECTIVE: The authors assessed the setting of an initial diagnosis of alcohol use disorder among Medicare-enrolled women. METHODS: Using 2016-2022 Medicare fee-for-service claims, the authors identified the first alcohol use disorder diagnosis for women ages 18-64 years (N=116,2...

An immunocompetent, multifluorescent resource for real-time analysis of osteosarcoma progression, metastasis, and response to therapy

Despite substantial treatment improvements, the 5-year survival rate for metastatic osteosarcoma (OS) is still as low as 20%. Immunocompetent genetic mouse models of OS have been introduced, enabling in vivo OS studies. Here, we present the ROCCIA mouse, a quintuple-mutant extens...

Enhancing the Role of Digital Health Navigators With Lived Experience: AI-Assisted Conavigation for Safety, Support, and Engagement

As artificial intelligence (AI) expands across mental health services, questions arise about whether it can replace digital health navigators (DHNs), including those with lived experience. The DHN role generally resists automation because lived experience deepens specific dimensi...

Immune correlates of protection are exposure-dependent: evidence from the Dominican Republic

Immune protection against infection is often treated as a fixed property of a person’s immune response. But infection risk also depends on the number of infectious contacts a person experiences, which generally increases as community transmission rises. This matters for vaccine e...

A TERRA-NONO axis drives fibroblast reprogramming in cancer

The molecular mechanisms linking chromosome homeostasis to fibroblast reprogramming into cancer-associated fibroblasts (CAFs) remain poorly understood. Here, we identify a clinically relevant, telomere-associated nuclear pathway driving CAF activation across multiple human cancer...

US Food and Drug Administration Officials’ Public Statements on Regulatory Flexibility in New Drug Approval, 2021–2024

The US Food and Drug Administration (FDA) has historically exercised substantial regulatory flexibility to adjust the type, amount, and quality of evidence necessary to support drug approval for areas of unmet need. Our objective was to characterize how FDA officials described an...

A rapid, inexpensive diagnostic for bacterial pathogen and resistance detection in resource-limited settings

Antimicrobial resistance is a major global health threat, with disproportionate impact in regions with limited diagnostic infrastructure. To address this challenge, we developed BADLOCK (Bacterial and AMR Detection by SHERLOCK), a rapid, low-cost molecular diagnostic platform for...

Assessing and Addressing Frailty in Candidates for Lung Transplantation: An ISHLT Consensus Statement.

The ISHLT Consensus document for the selection of lung transplant candidates recommends frailty assessment as part of a comprehensive candidacy evaluation. Missing from this and other recent consensus documents were practical recommendations on which frailty measures to consider...

Acanthamoeba ATP synthase structure reveals the TCA cycle is tethered to OXPHOS

Oxidative phosphorylation (OXPHOS) is a key metabolic process that couples redox energy to ATP production. While some core OXPHOS complex subunits are found across all domains of life, many have diverged or expanded across evolution—as seen in the protozoan pathogen Acanthamoeba...

A high-confidence plant mitochondrial proteome via protein correlation profiling

Plant mitochondria share many features with animal mitochondria but also possess unique traits, including presence of both circular and linear mitochondrial DNA, RNA editing, a branched electron transport chain, and metabolic pathways supporting photosynthesis. An accurate mitoch...

Comparative analysis of mitochondrial proteomes across the tree of life

Mitochondria arose from the endosymbiosis of a bacterium with an archaea-related host cell about 2 billion years ago. To understand their origins and evolution, we compared experimentally defined mitoproteomes from the MitoCarta Tree of Life project. Across eight organisms, we id...

Big data and psychiatry: advances, constraints and future directions.

Early work in psychiatry research, often involving single sites, small samples, and limited variables, has shifted to contemporary research involving multiple sites, large samples, and many variables. Such research raises important questions, including concerns about data quality...

Conserved and divergent mitochondrial assemblies in kinetoplastid parasites

The mitochondrial proteomes of Leishmania tarentolae and Trypanosoma brucei contain ∼1,700 proteins, most of which lack homologs in higher eukaryotes. Here, we integrate complexome profiling and cryo-electron microscopy to define conserved and lineage-specific macromolecular asse...

Mitochondrial carrier SLC25A34 links clock, diet, and temperature control of adipocyte lipid cycling

Adipocyte lipid metabolism is coordinated by circadian rhythms, diet, and environmental temperature, but how these diverse signals are molecularly integrated remains unknown. We showed that these cues converge on the orphan mitochondrial transporter SLC25A34 to orchestrate lipid...