Harvard University

Human-like content analysis for generative AI with language-grounded sparse encoders

The rapid development of generative AI has transformed content creation, communication, and human development. However, this technology raises profound concerns in high-stakes domains, demanding rigorous methods to analyze and evaluate AI-generated content. While existing analyti...

Reproductive Privacy Risk Disclosure in US Clinical Trial Informed Consent Forms After the Dobbs Decision

This study examines the practice of pregnancy information disclosure by trial participants in the post– Dobbs v Jackson Women’s Health Organization US health research setting.

21-Gene recurrence score assay in pN2-3 Early-Stage breast cancer: a national cancer database study

BACKGROUND: The clinical utility of the 21-gene recurrence score (RS) for guiding adjuvant chemotherapy in patients with pN2-3 early-stage breast cancer (eBC) has not been evaluated in prospective trials. This study aims to assess adjuvant chemotherapy benefit in patients with pN...

Lung Function–Associated Genetic Variants and Overall Survival in Non–Small Cell Lung Cancer: A Multi-Platform Analysis

Abstract Background: Genome-wide association studies (GWAS) have identified numerous variants associated with spirometric lung function, and Mendelian randomization studies suggest that impaired pulmonary function contributes to lung cancer susceptibility. Whether these variants...

Efficient septum formation is essential for chromosome segregation in Bacillus subtilis when SMC function is impaired

ABSTRACT Structural maintenance of chromosomes (SMC) complexes play conserved roles in chromosome organization, segregation, and repair in all domains of life. In Bacillus subtilis , SMC is required for the segregation of newly replicated origins. To investigate whether other pro...

Mobility hinders malaria elimination goals in the Brazilian Amazon

Introduction Human mobility across the Brazilian Amazon—shaped by frontier development, land-use change, mining activity, and climatic shocks—remains a major barrier to malaria elimination. Brazil aims to eliminate Plasmodium falciparum (Pf) by 2030 and Plasmodium vivax (Pv) by 2...

Trading Off Business and Family Investments: Evidence from U.S. Entrepreneurial Households

Investing in children’s human capital reduces business investments for U.S. entrepreneurial households. Using financial account data of 90,000 small businesses linked to their owners and a regression discontinuity design that compares the business performance of households with c...

MRI Visualization of Melatonin‐Promoted Oligodendrogenesis and Its Neuroprotective Effects in Preterm White Matter Injury Rat Model

Preterm white matter injury (PWMI) is a serious neurologic condition that threatens neonatal survival and severely impairs the cognitive and motor development of affected children. Melatonin (Mel), a neuroendocrine hormone with anti-inflammatory and antioxidant properties, has sh...

Device-Measured Physical Activity, Sedentary Time, and Cardiometabolic Risk Markers in Youth

Importance The evidence for benefits of higher physical activity and lower sedentary time on the cardiometabolic risk profile in youth is based on cross-sectional and small prospective studies. Objective To determine the prospective associations between device-measured physical a...

Exclusion of Participants for Substance Use in Clinical Trials

Patterns of inclusion and exclusion of individuals who use illicit substances from clinical trials have not been well-studied. Given the widespread and increasing prevalence of drug use in the United States, this has significant implications for the generalizability of scientific...

The Framework for Policy Decision on the RTS,S/AS01 malaria vaccine: the use of emerging data to inform global policy on the first malaria vaccine

The World Health Organization (WHO)-coordinated Malaria Vaccine Implementation Programme (MVIP) supported pilot introductions of the RTS,S/AS01 malaria vaccine by the ministries of health through the childhood immunization programmes in Ghana, Kenya and Malawi from 2019 through 2...

Sensitivity to ATR–CHK1 pathway inhibition in MDS/AML is enhanced by SRSF2 mutations and reduced by RUNX1 loss

Abstract SRSF2 mutations occur in 5–15% of acute myeloid leukemia (AML) and ~15% of myelodysplastic neoplasms (MDS), are enriched in elderly/secondary AML, and lack mutation-directed therapy. We aimed to identify vulnerabilities in MDS/AML with SRSF2 mutations. Ex vivo drug-sensi...

The Left Atrial Appendage: Anatomy, Electrophysiology, and Clinical Implications for Atrial Fibrillation and Stroke

Abstract Purpose of Review The left atrial appendage (LAA) is nowadays recognized as both an arrhythmogenic substrate and the dominant source of thromboembolism in atrial fibrillation (AF). In this review we tried to summarize recent data on the anatomy, physiology, and imaging o...

Prognostic implications of complications during VA-ECMO for cardiogenic shock

PURPOSE: Veno-arterial extracorporeal oxygenation (VA-ECMO) provides comprehensive cardiopulmonary support in patients with cardiogenic shock (CS), but may result in complications. While complications rates are known, their impact on risk of death remains largely unknown. METHODS...

PSHIC reveals allele-specific chromatin organization by phasing-free structural modeling

Resolving the distinct 3D chromatin architectures of parental chromosomes is critical for understanding diploid genome function, but many haplotype-resolved Hi-C contact-map methods remain constrained by their reliance on phased single-nucleotide polymorphisms (SNPs). This depend...

Feasibility, acceptability, and preliminary estimates of a multimodal AKTIVER Heart Delirium Prevention Program in patients indicated for cardiac surgery: study protocol of a randomized controlled PREVENT POstoperative Delirium (PREVENT-POD) Pilot Study

Abstract Background Postoperative delirium (POD) is a common complication in geriatric patients undergoing cardiac surgery. POD is associated with prolonged length of stay in the intensive care unit and hospital, increased mortality, institutionalization, distress, risk of cognit...

Pancreatic Reirradiation: A Multi-Institutional Retrospective Analysis of Feasibility, Tolerability, and Clinical Outcomes

Objectives: With improvements in systemic therapy for pancreatic cancer (PC), the role of radiation therapy (RT) to optimize local control has increased. While the tolerability and outcomes for RT for PC are well described, limited data exist on the feasibility and clinical impac...

The Multidimensional Nature of Pediatric Patient Complexity

OBJECTIVE: Patient complexity is defined in a variety of ways and is associated with health care costs and use. In this study, we evaluate whether pediatric inpatient complexity represents a single construct or multiple domains using multiple measures of diagnostic burden, health...

Maternal healthcare quality, continuity, and experiences among pregnant adolescents and adult women in Ethiopia, Kenya, and South Africa: A cohort study

The capacity of health systems to provide quality care for pregnant adolescents remains underexplored. This study examined the quality, continuity, and experiences of maternal healthcare among pregnant adolescents (<20 years) compared with adult women (20 + years) in Ethiopia, Ke...

Anticancer Drugs and Cancer-Associated Thrombosis

The rapid development of novel cancer therapies has considerably improved the care of cancer patients and cancer-related survival; however, these therapies are associated with a broad range of adverse events that have become a major burden in this population. Alongside other canc...