Harvard University

Age-Associated Cognitive Deviations in Early-Onset Psychosis Patients and Their Siblings

OBJECTIVE: The objective of this study was to test for cognitive impairments and cross-sectional age-associated cognitive deviations in a large, diagnostically diverse, cross-sectional sample of children and adolescents with early-onset psychosis (EOP), their siblings, and nonpsy...

Visualizing Mathieu-type dynamics in a tabletop magnetic trap: A coil-driven parametric oscillator

We present a tabletop demonstration of dynamic stabilization and ponderomotive-like trapping using a pair of sinusoidally driven anti-Helmholtz coils and a suspended permanent magnet. The oscillating field produces a rapid micromotion superimposed on a slower secular oscillation,...

Global policy determinants of national human papillomavirus vaccine introductions in 2006–2025

BACKGROUND: Although safe and effective human papillomavirus (HPV) vaccines have been available since 2006, national introduction in low- and middle-income countries (LMICs) has progressed slowly. HPV vaccine adoption may have been shaped by evolving World Health Organization (WH...

Prevalence of meeting aerobic physical activity and resistance training guidelines in advanced prostate cancer: a descriptive study of racial and regional disparities in the IRONMAN registry

Abstract Purpose To estimate guideline-based aerobic physical activity and resistance training participation in an international population of people with newly diagnosed metastatic hormone-sensitive or castration-resistant prostate cancer, and to assess racial and regional diffe...

Actionable genetic landscape and dynamics in circulating DNA from 12,827 patients with metastatic breast cancer

Abstract Plasma cell-free DNA (cfDNA) is a sensitive, noninvasive tool for monitoring the genomic landscape, heterogeneity, and evolution of cancer, aggregating genetic information from multiple metastatic sites. Here, we study 15,564 cfDNA samples from 12,827 patients with metas...

Developmental differences in platelet P-selectin expression modulate neonatal monocyte inflammatory responses

Neonatal and adult platelets are functionally different, with neonatal platelets being comparatively hypo-reactive to multiple platelet agonists. When transfused, neonates receive platelets from adult donors, resulting in a cellular developmental mismatch. Platelets are key regul...

An iron-regulated methionine redox axis governs adipose browning and cancer cachexia

Abstract Adipose browning and atrophy are early events of cachexia, a lethal metabolic disorder affecting nearly half of the population with cancer. Here, using individual-derived specimens and mouse models, we identified an iron-dependent pathway that initiates adipose browning...

MUC5AC in pancreatic cancer and precursors: a systematic review and meta-analysis

Abstract Background Mucin5AC (MUC5AC) is a secretory glycoprotein that is highly expressed in pancreatic cancer and precursors. We assessed its diagnostic accuracy in differentiating pancreatic cancer and precursors from normal pancreas and benign pancreatic diseases. Methods Sys...

HSP90 shields ROC1/RBX1 from proteasomal degradation by CHIP E3 ubiquitin ligase to promote lung adenocarcinoma

The Regulator of Cullins 1 (ROC1) or RING box protein-1 (RBX1) is an essential component of the largest multiunit Cullin-RING ubiquitin ligase (CRL). Previous studies demonstrated that ROC1 is frequently overexpressed in multiple malignancies, which predicts advanced cancer stage...

Mediterranean lifestyle and risk of recurrent cardiovascular events: a prospective study from the UK biobank

Abstract Background The Mediterranean Lifestyle Index (MEDLIFE) evaluates adherence to traditional Mediterranean living, encompassing diet, physical activity, rest and conviviality. Although it has been linked to reduced risk of cardiovascular disease (CVD), diabetes, and other c...

Gut microbiome maturation in early childhood interacts with host genetics to predict type 1 diabetes risk

Prospective evidence linking early-life microbiome development and host genetics with type 1 diabetes (T1D) risk is limited. Here, we describe how gut microbiome maturation and host genetics influence T1D risk in the TEDDY study. We analysed 12,151 longitudinal metagenomes and ho...

RamanOmics decodes the spatial vibrational–molecular architecture of senescence in aging and repair

Aging and tissue repair involve heterogeneous remodeling across transcriptional, biochemical and cellular dimensions, yet prevailing definitions rely on isolated molecular markers that obscure how these states co-evolve. Here we present RamanOmics, a multimodal framework integrat...

Utility and best practices for clinical diagnostic testing of the autonomic nervous system: A Consensus Statement Endorsed by the American Autonomic Society and the American Association of Neuromuscular & Electrodiagnostic Medicine

Abstract Purpose Disorders of the autonomic nervous system are prevalent and associated with substantial morbidity, mortality and diagnostic delay. Standardized, laboratory-based autonomic function testing provides objective physiological data essential for diagnosing, staging, a...

Modifiable Lifestyle Factors in Cardiovascular Disease Prevention: Current Evidence and Future Directions

Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality worldwide despite substantial advances in pharmacologic and interventional therapies. Modifiable lifestyle behaviors are major determinants of cardiovascular risk and essential targets for primary a...

Genome-wide analysis of social behaviour across social domains, reporters and developmental stages: a meta-regression approach

Abstract Social behaviour is a heritable trait linked to well-being and mental health, yet it varies across social context, including social domains, informants and development, which may shape its underlying genomic architecture. Here, we conducted a genome-wide meta-regression...

T9. BRAIN–BONE CROSSTALK IN SCHIZOPHRENIA-ASSOCIATED OSTEOPOROSIS: FROM BRAIN-CENTERED THERAPY TO BRAIN–BONE CO-TREATMENT

Background Schizophrenia is increasingly recognized as a systemic disorder rather than a purely brain-centered psychiatric disease. Osteoporosis and fragility fractures are underrecognized but clinically important comorbidities in patients with schizophrenia, who often show reduc...

Tumor Vascular Features and Colorectal Cancer–Specific Mortality

Importance The phenotypic and morphologic heterogeneity of tumor vasculature in colorectal cancer (CRC) has been increasingly recognized; however, its clinical importance remains unclear. Objective To examine whether specific tumor vascular features are associated with CRC-specif...

Physician Understanding and Perceptions of Risk Communication Related to Drugs Covered by Risk Evaluation and Mitigation Strategy Programs

ABSTRACT Purpose To help ensure that a drug's benefits outweigh its risks, the US Food and Drug Administration may require a Risk Evaluation and Mitigation Strategy (REMS) program with requirements such as laboratory tests or special education. Since physicians are often responsi...

Capturing Heterogeneous Time‐Variation in Covariate Effects in Non‐Proportional Hazard Regression Models

ABSTRACT A central focus in survival analysis is examining how covariates affect survival time. These covariate effects are often found to be either time‐varying, heterogeneous—such as being specific to patients, treatments, or subgroups—or exhibit both characteristics simultaneo...

The psychological impact of traumatic invalidation among U.S. Jewish adults after October 7, 2023

This study examined traumatic invalidation (TI), the extreme dismissal of an individual’s experiences, characteristics, or beliefs, specifically in the Jewish community. We investigated the prevalence and psychological impact of identity-based TI among 733 Jewish adults in the Un...