Harvard University

Beyond the ‘Big Three’: Prospective Associations Between Cumulative Lifestyle Protective Factors and Subsequent Adolescent Wellbeing

ABSTRACT Introduction Lifestyle factors are increasingly recognized as important correlates of adolescent mental health and wellbeing. However, existing research has largely focused on sleep, nutrition, and physical activity in isolation, with less attention to cumulative multido...

Rigorous Evaluation of Microarchitectural Side-Channels with Statistical Model Checking

Rigorous quantitative evaluation of microarchitectural side channels is challenging for two reasons. First, the processors, attacks, and defenses often exhibit probabilistic behaviors. These probabilistic behaviors arise due to natural noise in systems (e.g., from co-running proc...

Perceived criminal behavior in frontotemporal dementia: A 10‐year retrospective analysis of forensic cases in Türkiye

Abstract Frontotemporal dementia (FTD) is associated with a disproportionately high risk of behavior perceived as criminal, yet systematic forensic data from non‐Western settings remain scarce. This retrospective descriptive study characterized the sociodemographic, clinical, and...

Longitudinal Trends and Characteristics of Hospital Closures and Openings

This study assesses hospital closures and openings from 2010-2025 to characterize net changes in hospitals and beds, factors associated with closures and openings, and changes in distance to the nearest hospital after closures.

Development and Validation of a Tool to Measure Documented Health Care Encounter Time

Importance Time toxicity, defined as the time patients spend receiving cancer treatment and interacting with health care systems, is an emerging treatment-related burden. Existing studies typically quantify time toxicity using health care contact days, which may inadequately capt...

Impact of Extent of Surgical Resection on Survival in Patients With High-risk Neuroblastoma

Objective: The impact of extent of resection of the primary tumor on outcomes in patients with high-risk neuroblastoma (HRNB) remains uncertain. We evaluated this issue in patients with HRNB treated on a prospective trial of multimodality therapy. Summary of Background Data: Pati...

Structural basis for regulating lipopolysaccharide transmembrane transport

Gram-negative bacteria are surrounded by a multilayered cell envelope with a mostly impermeable outer membrane that provides intrinsic resistance to many antibiotics1–5. The outer membrane is an asymmetrical bilayer with phospholipids in the inner leaflet and lipopolysaccharide (...

CGM-derived disposition index estimates beta cell function in individuals with islet autoimmunity who do not require insulin treatment; changes in the disposition index precede changes identified by CGM metrics 1 year later

Abstract Aims/hypothesis Monitoring of beta cell function in individuals with islet autoimmunity who do not require insulin treatment (preclinical type 1 diabetes) is normally done via OGTTs, posing major challenges given the invasiveness of the test. Here, we validated a disposi...

Outcomes for American Indian and Alaska Native Populations With Cancer in Traditional Medicare

Importance American Indian and Alaska Native patients represent a uniquely vulnerable population in the US. Epidemiological studies have shown significant health disparities within this group. Contemporary outcomes and utilization studies of cancer in this population could aid in...

A multiomic atlas reveals distinct immune landscapes in preterm and term chronic placental inflammation

Chronic placental inflammation (CPI), an umbrella term encompassing chronic chorioamnionitis, chronic villitis, and chronic deciduitis, is associated with preterm birth (PTB), yet its cellular and molecular determinants across gestation remain poorly defined. Here, we constructed...

Innovative application of pressure gradient measurement in internal carotid stenosis in patients undergoing carotid artery stenting (NOTICE-CAS): study protocol for a randomized, assessor-blinded, parallel-group clinical trial

Atherosclerotic stenosis of the internal carotid artery (ICA-S) is among the significant causes of ischemic stroke. Current noninvasive imaging techniques often lack the precision to accurately determine hemodynamic significance. Although carotid artery stenting (CAS) is benefici...

Human-like content analysis for generative AI with language-grounded sparse encoders

The rapid development of generative AI has transformed content creation, communication, and human development. However, this technology raises profound concerns in high-stakes domains, demanding rigorous methods to analyze and evaluate AI-generated content. While existing analyti...

Creating an Ear and Hearing Health Culture for Professional Ear Users: Current Perspectives on Challenges, Management, and Recommendations

Professional ear users (PEUs), including musicians, instrument makers, or sound engineers, depend on highly trained auditory abilities for occupational performance. Given these demands, PEUs may benefit from tailored prevention, diagnostics, and treatment. Ear and hearing disorde...

Human trilayer engineered blood vessel reveals influence of fibroblasts on disease progression in model of Hutchinson-Gilford progeria

In vitro models of vascular disease have focused primarily on the pathophysiology of smooth muscle cell (SMC) or endothelial cell (EC). Adventitial fibroblasts can contribute to disease progression, but their specific influence is not well understood in different disease contexts...

Challenges for the effectiveness of infectious disease interventions during global change

Global change, including climate change, land-use change, and increased human mobility, is expected to have complex effects on the transmission, evolution, and emergence of infectious diseases 1 , 2 . Current research agendas aim to understand how these environmental and anthropo...

Deploying Meaningful Medical Informatics and Artificial Intelligence Solutions in the Clinical Field: A Call to Action for Researchers in Cardio-Oncology Informatics

Abstract Rapid advances in oncology care have resulted in a growing population of cancer survivors, many of whom suffer from short- and long-term cancer therapy related cardiovascular toxicities (CTR-CVT). Cardio-oncology aims to diagnose and manage these cardiovascular condition...

A systematic review of hydrocephalus and psychiatric comorbidities in children and adults with spina bifida

Spina bifida in children and adults is accompanied by substantial psychiatric comorbidity. Hydrocephalus is a common complication of spina bifida and is associated with functional and cognitive deficits, but the role of hydrocephalus in psychiatric comorbidities of spina bifida i...

Multidisciplinary Support for Children With Genodermatoses in Brazil: A RE ‐ AIM Evaluation of Casa Santa Teresinha's Community‐Based Model

ABSTRACT Genodermatoses impose substantial psychosocial and functional burdens on affected children and their families, yet structured community‐based support models remain underrepresented in the literature. We describe Casa Santa Teresinha , a Brazilian non‐profit organization...

Epigenetic insights into extreme longevity in the world’s oldest terrestrial animal, Jonathan

Aldabra giant tortoises ( Aldabrachelys gigantea ) are exceptionally long-lived. We sequenced the genome and methylome of Jonathan, a 194-year-old Aldabra, to explore the molecular basis of his longevity. Relative to other giant tortoises ( A. gigantea and Chelonoidis abingdonii...

Potential health impacts and costs of active case finding guided by Mycobacterium tuberculosis immunoreactivity survey results in Blantyre, Malawi: A mathematical modeling study

Background Active case finding (ACF) for tuberculosis (TB) can reduce transmission, yet efficient targeting requires high-quality surveillance data. We investigated the potential costs and impact of targeted ACF, guided by local estimates of the annual risk of TB infection (ARTI)...