Harvard University

Gestational Diabetes Mellitus: Recurrence and Future Type 2 Diabetes Risk Across Racial and Ethnic Groups

OBJECTIVE Despite rising diabetes prevalence among women, data on long-term diabetes risk following gestational diabetes mellitus (GDM), particularly its recurrence, remain limited, especially for Asian women. This study examined associations among GDM, its recurrence, and subseq...

Developing Consensus Using the Delphi Method

The Delphi method is a technique for obtaining consensus from a panel of experts on a particular topic or set of decisions, such as diagnostic or treatment algorithms, medical education competencies, or curricular components. This article aims to introduce researchers new to cons...

Acquired resistance to the RAS(ON) multi-selective inhibitor daraxonrasib guides rational combination therapy strategies in pancreatic cancer

Abstract Daraxonrasib is an orally bioavailable RAS(ON) multi-selective tri-complex inhibitor of the oncogenic mutant and wild-type variants of N, H and KRAS. We previously reported encouraging efficacy in a phase 1/2 clinical trial evaluating daraxonrasib monotherapy at clinical...

Rural-Urban Disparities in Contemporary Systemic Therapy for Advanced Prostate Cancer

This cross-sectional study examines the associations of rural-urban residence and race with receipt of systemic therapy for advanced prostate cancer.

Longitudinal Quantitative Mapping of Meniscal Morphological and Signal Intensity Differences After ACL Surgery

BACKGROUND: Meniscal tears are frequently associated with anterior cruciate ligament (ACL) injuries. Evaluating longitudinal changes in meniscal integrity using quantitative magnetic resonance imaging after ACL surgery may provide valuable insight into joint recovery and subseque...

‘Talk CKD Options’: improving how clinicians communicate treatment options in advanced kidney disease using a conversation analysis-based training intervention

Abstract Background Most older people with kidney failure and multiple co-morbidities must decide between dialysis or conservative kidney management. Dialysis is often presented as the default, despite providing uncertain survival benefits in this population. The Optimising Staff...

Deletion of the Salmonella pathogenicity island 2 gene, spiC , in attenuated Salmonella Typhimurium VNP20009 optimizes its potential for bacterial schwannoma therapy

ABSTRACT Recent advances in systems biology and immunotherapy have spurred the use of bacteria as therapeutic vehicles for cancer treatment. Currently, Bacillus Calmette–Guérin remains the only FDA-approved bacterial strain for high-risk, non–muscle-invasive bladder cancer. Altho...

Comprehensive Analysis of US Health Care Spending on Injuries

BACKGROUND: Traumatic injury affects every age group, payer, and care setting in the United States, yet how injury-related spending distributes across these dimensions has not been comprehensively quantified. OBJECTIVE: To estimate US health care spending on injuries in 2022 by m...

Cannabinoids suppress chemotherapy- and ionizing radiation-induced apoptosis of glioblastoma cells

Abstract Cancer patients are increasingly exposed to cannabinoids, the bioactive molecules produced by the Cannabis sativa La. plant. This trend is being driven by several factors: expanding cannabis legalization, FDA approval of select cannabinoids for the treatment of seizures...

Modeling effective doses of therapeutic antibodies targeting clustered surface receptors

Abstract A longstanding practice for therapeutic dosing of monoclonal antibodies is to identify the maximally tolerated dose. However, this approach has encountered limited success with some antibodies, especially in failed cancer trials. Here we report on an alternative dose-fin...

A clinical analysis of the presentation of depression in Pakistan

Background Major depressive disorder is a leading cause of disability worldwide, yet its clinical presentation varies substantially across cultural contexts. In many low- and middle-income settings, including Pakistan, depression is frequently expressed through somatic rather tha...

Advocacy around abortion in a politically charged climate

PURPOSE OF REVIEW: To examine the evolving role of clinician advocacy in abortion care and to highlight key domains through which obstetrician-gynecologists can influence policy, clinical practice, and patient outcomes. RECENT FINDINGS: Increasing state-level abortion restriction...

Evaluating the costs of developing a digital supervision tool for task-shared depression care: findings from a multi-site study in India

BACKGROUND: Task-sharing with non-specialist providers offers a promising solution to the mental health workforce shortage in low-resource settings. Supervision is essential to ensure treatment quality, but is often constrained by limited specialist availability. AIMS: This study...

Pseudomonas aeruginosa-derived volatile organic compounds modulate AhR signaling to dysregulate airway mucus homeostasis

Pseudomonas aeruginosa frequently infects chronically diseased lungs and exacerbates airway mucus hypersecretion and failure in clearance. P. aeruginosa is metabolically versatile and secretes multiple volatile organic compounds (VOCs), which have been scrutinized as potential bi...

Safety and Tolerability of Chronic Carvedilol in Pediatric Dilated Cardiomyopathy: A Report from the Pediatric Cardiomyopathy Registry

Long-term studies on safety of beta-blockers in pediatric heart failure (HF) are scant. We describe the safety profile, dose ranges, and tolerability of carvedilol in pediatric dilated cardiomyopathy (DCM). The Pediatric Cardiomyopathy Registry (PCMR) was used to identify patient...

Challenges and approaches to genetic variants of uncertain significance in clinical practice and research

Despite advances in sequencing technologies and variant interpretation frameworks, many variants identified in genetic testing, particularly missense variants, remain classified as variants of uncertain significance (VUS), posing ongoing challenges in diagnosis and clinical manag...

The Role of Assignment in Defining and Identifying Causal Effects in Randomized Trials

In randomized trials, the per-protocol effect is defined as the effect of being assigned a treatment strategy and receiving treatment according to the assigned strategy; therefore, it encompasses the effect of the treatment strategy and any effect of assignment that does not oper...

Money, Meals, and Marketing in Medicine: A 13‐Year Follow‐Up Survey of Physicians

Pharmaceutical company marketing to physicians is known to impact prescribing patterns. In 2011, we surveyed medical students and residents about physician/industry relationships. In 2024, we resurveyed the same participants to study changes in their behaviors over time and their...

Longitudinal evaluation of sleep disturbances in survivors of childhood cancer: a report from the Childhood Cancer Survivor Study

Abstract Purpose The current study examines longitudinal changes in sleep disturbances and the risks they pose for new-onset health conditions in survivors of childhood cancer. Methods Five-year survivors ( N = 1081; median [range] age 50.0 [45.2–55.0] years) and siblings ( N = 2...

Characteristics of Patients Undergoing Revision Thumb CMC Arthroplasty

Purpose The purpose of this study was to describe the demographic and operative characteristics of patients undergoing revision thumb carpometacarpal (CMC) arthroplasty and to characterize technique transitions from primary to revision surgery. Methods A retrospective review of r...