Harvard University

An rRNA hybridization-based approach for rapid and accurate identification of diverse fungal pathogens

species, to identify diverse fungal pathogens. We created a set of 91 probes targeting 86 medically relevant fungal species, designed to recognize regions of differential conservation across taxonomic groupings, from class- to species-specific probes. We assessed assay performanc...

Universality for the global spectrum of random inner-product kernel matrices in the polynomial regime

We consider certain large random matrices, called random inner-product kernel matrices, which are essentially given by a nonlinear function f applied entrywise to a sample-covariance matrix, f(XTX), where X∈Rd×N is random and normalized in such a way that f typically has order-on...

Tumor microbial biodiversity and microsatellite instability in colorectal cancer

Background Growing evidence links the gut microbiome to colorectal cancer (CRC) progression, with certain bacterial species enriched in specific molecular tumor subtypes. DNA mismatch repair deficiency in CRC, evidenced by the presence of microsatellite instability (MSI), has bee...

Positive selection screen identifies natural product β-catenin inactivators

Many genetically validated targets in cancer, including the transcription factor β-catenin (β-cat), have historically been viewed as undruggable. Cell-based phenotypic screening of chemical compounds can reveal unanticipated biological and pharmacological principles. Natural prod...

Tunable nanofluidic ion gating via in situ salt precipitation-dissolution

Nanofluidic ion gating underpins both biological signal transduction and iontronic signal processing. However, a simple and reliable mechanism that functions independently of local electrochemical conditions remains unavailable, hindering interference-free integration of artifici...

A cross-species atlas platform for comparative neuroscience in teleost fish

Abstract Uncovering general principles connecting neural circuits to behaviour requires comparative brain analyses across species. To advance these efforts, we developed a standardised workflow and a unified brain atlas platform for the quantitative comparison of neural structure...

Population coding under the scale invariance of high-dimensional noise

High-dimensional scale-invariant neural activity is ubiquitous across brain regions and species, but its implications for information coding remain unclear. Here, we ask how stimulus information in the high-dimensional activity of mouse V1 scales with neuron number: Does it satur...

Sikh Youth in Child and Adolescent Psychiatry: A Clinical Perspective

Sikh children and adolescents represent a growing but understudied population in child and adolescent psychiatry. Many Sikh youth navigate complex intersections of religious identity, family expectations, migration experiences, and minority stress, particularly in diaspora contex...

Photochemical Oxygen‐Atom‐Transfer Reactivity of Platinum(II) Peroxycarbonates

ABSTRACT Peroxycarbonate (CO 4 2– ) is implicated in various biological, catalytic, and energy storage processes – despite the capability of transition metals to guide the reactivity of this unstable intermediate toward productive ends, the coordination chemistry of metal–peroxyc...

Reducing Serum Bilirubin Measurements in a Newborn Nursery Using Quality Improvement Methodology

BACKGROUND: Transcutaneous bilirubin (TcB) screening in the newborn nursery (NBN) is noninvasive and appropriate for most infants; however, reported rates of total serum bilirubin (TSB) measurement remain at 17% to 30%. OBJECTIVE: From January to December 2024, 17.2% of infants s...

Trends in Regionalization of Pediatric Inpatient and Critical Care by Medical Complexity

BACKGROUND AND OBJECTIVES: Pediatric inpatient and critical care services are increasingly regionalizing: shifting from smaller hospitals to larger specialty centers. Children with medical complexity (CMC) and with technology dependence (TD) account for a disproportionate share o...

Variations in diagnosis and management of hemodynamically significant patent ductus arteriosus across neonatal intensive care units in the Children’s Hospitals Neonatal Consortium

Abstract Objective Collate patent ductus arteriosus (PDA) guidelines among Children’s Hospitals Neonatal Consortium (CHNC) centers and identify variations in the diagnosis and management of hemodynamically significant PDA (hsPDA). Study Design: A descriptive survey requesting wri...

From Donor-Supported Programming to State-Embedded Diagonal Health System Strengthening: Lessons from the Bihar Technical Support Program in India

Donor-supported health programs in resource-limited settings often begin with urgent service delivery priorities, but their lasting value depends on whether service-specific investments also strengthen the public health system delivering care. This essay examines the Bihar Techni...

Screening of Brazilian Isolated Yeasts Reveals Multiple Potential Chassis for Industrial Biotechnology

ABSTRACT The future of sustainable industrial biotechnology relies on microbial hosts that can thrive where conventional strains fail. Although Saccharomyces cerevisiae remains the dominant industrial yeast, its metabolic constraints and stress sensitivity highlight the need for...

Apparent Intramyocellular Lipid Index Using Spiral Magnetic Resonance Spectroscopic Imaging at 3 T

Abstract Purpose: This work introduces a rapid, high-resolution method based on spiral Magnetic Resonance Spectroscopy Imaging (MRSI) to map the apparent content of intramyocellular (IMCL) and extramyocellular (EMCL) lipids in human skeletal muscle. Methods: Unsuppressed water sp...

Coated or chewable Aspirin and a hybrid air pollution mitigation strategy in patients with atherosclerotic disease: Rationale and Design of the COATED-AIR Randomized Trial.

BACKGROUND: Although enteric-coated aspirin is widely used instead of chewable formulations in patients with atherosclerotic cardiovascular diseases (ASCVD), its effects on cardiovascular and gastrointestinal outcomes remain uncertain. Separately, air pollution is a driver of car...

Stabilizing telerobotic endobronchial imaging and interventions in breathing lungs with a helical brace

Physiological motion in dynamic luminal organs, such as respiration-induced lung displacement, compromises the stability of tool-tissue interaction during telerobotic endoluminal imaging and interventions. However, existing devices for stabilizing the distal end of a catheter or...

Exploratory data analysis of tonometry and PTT/PIR signals for cuffless blood pressure monitoring: dynamic responsiveness versus baseline stability

OBJECTIVE: Sensing modalities for cuffless blood pressure (BP) monitoring remain insufficiently characterized. To address this, we used exploratory data analysis (EDA) to evaluate multimodal physiological signals' associations with reference BP, to gain insight into their BP-rela...

Association between chiropractic spinal manipulation and adverse vascular events of the head and neck: systematic review and meta-analysis

Abstract Background Observational studies have raised concerns about a potential association between chiropractic spinal manipulation (CSM) and craniocervical vascular events (CCVE), including cervical artery dissection and stroke. We tested the null hypothesis of no significant...

Beyond statistical thresholds: Mapping sequential ATN cascade transitions via brain structural topography in Alzheimer’s disease

Alzheimer’s disease is widely conceptualized as a biological continuum initiated by amyloid-β (Aβ) accumulation, followed by tau aggregation and neurodegeneration. Although the ATN framework is commonly used to define disease stages, its static biomarker categories may not fully...