Harvard University

Morphology and Ion Transport in Zwitterionic Polysiloxanes

Abstract The recent discovery of superionic conductivity in doped polyzwitterions (PZIs) has opened a new direction for polymer electrolytes (PEs). Solid-state battery research is currently dominated by inorganic electrolytes due to their rigidity and high conductivity, but they...

Rural Family Medicine–General Surgery Dyads and Health Outcomes

Importance Despite a 43% higher age-adjusted mortality rate among rural working-age adults and a 29.1% decline in general surgeon supply between 2001 and 2019, the public health impact of the family medicine–general surgery (FM-GS) specialty dyad remains understudied. Objective T...

Deep hydrous melting of the mantle wedge recorded by Mg isotopes

Subduction zones govern Earth’s deep volatile cycle. The slab-mantle interface is a key locus of volatile exchange between the subducting crust and the overlying mantle wedge, yet whether and how chemical reactions at this interface affect arc magmatism remains poorly constrained...

Poison exon splicing in the human brain provides a new paradigm for understanding and targeting neurological disorders

Poison exons are highly conserved exons whose inclusion creates premature termination codons and triggers nonsense-mediated decay (NMD) of the mature transcript. Despite their important role in post-transcriptional regulation, poison exons remain poorly annotated due to the lack...

Real-World Versus Centers for Medicare and Medicaid Services Estimates of Pediatric Retinal Detachment Repair Times

Purpose: To compare real-world pediatric retinal detachment (RD) repair times with the Centers for Medicare and Medicaid Services (CMS) estimates for complex RD surgeries. Methods: A cross-sectional survey was performed of complex pediatric RD perioperative times from pediatric r...

Machine Learning on Heterogeneous, Edge, and Quantum Hardware for Particle Physics

The next generation of particle physics experiments will face an era of challenges in data acquisition, due to unprecedented data rates and volumes along with extreme environments and operational constraints. Harnessing these data for scientific discovery demands real-time infere...

Data and code for: Online Search Interest in Facial Aesthetic Procedures Across Nine Countries From 2004 to 2026: A 22-Year Google Trends Analysis

This deposit contains the Google Trends export files exactly as downloaded, the download verification record, the cleaned analysis dataset, and all analysis code for the study named above. It allows an independent reader to reproduce every number, table and figure in the article...

Proton Radiotherapy Decreases Incidence of Radiation‐Induced Second Malignant Neoplasms Compared to Photon Radiotherapy in Patients With Retinoblastoma

Retinoblastoma is the most common primary intraocular neoplasm in children. Use of radiotherapy has decreased due to the incidence of second malignant neoplasms (SMNs). In our study, photon (n = 42) and proton (n = 66) radiotherapy cohorts had median follow-up of 28.7 and 18.2 ye...

Enhancing learning health care systems with real-world data harmonization frameworks

The use of digital tools has enabled the capture of clinical data that can be leveraged to produce real-world evidence, complementing traditional trial data and addressing evidence gaps in oncology. Electronic health records offer rich, longitudinal data, although recording pract...

Svep1 orchestrates distal airway patterning and alveolar differentiation in murine lung development

Abstract Disruptions in airway branching or alveolar differentiation during lung development can lead to severe respiratory deficiencies and neonatal death. The molecular mechanisms governing branching patterning and early alveolar formation remain elusive. Loss of Svep1 function...

Recurrent PDGFRB-Mutations in the Epithelioid Variant of Fibrous Papules

Fibrous papule (FP) is a common benign dermal mesenchymal lesion presenting as a solitary, dome-shaped papule mostly located on the nose. The morphologic spectrum is broad, and a number of variants have been described, including hypercellular, clear cell, pigmented, pleomorphic,...

Toxin-mediated tRNATrp depletion drives Trp-codon-dependent reprogramming in Mycobacterium tuberculosis while selectively enriching the PDIM biosynthetic machinery

Mycobacterium tuberculosis (Mtb) must adapt to host-imposed stresses that limit its growth and ability to establish an infection. One important immune-regulated host defense mechanism involves competition between host and pathogen for tryptophan (Trp). Although Mtb is a Trp proto...

Improving neuropathological reconstruction fidelity via AI slice imputation

Neuropathological analyses benefit from spatially precise volumetric reconstructions that enhance anatomical delineation and improve morphometric accuracy. Prior work has shown the feasibility of reconstructing 3D brain volumes from 2D dissection photographs. However, these outpu...

Delays in breast cancer presentation, diagnosis, and treatment in young women

BACKGROUND: Breast cancer (BC) in young patients is often identified at later stages, which can result in poor prognosis. It is important to investigate the factors influencing care delays and how delays affect outcomes. METHODS: This study included women aged ≤40 years at diagno...

Plasma Phosphorylated Tau 217 Percentage by Race and Ethnicity in Preclinical Alzheimer Disease

Importance In trials targeting preclinical Alzheimer disease (AD), defined as amyloid pathology without cognitive symptoms, racial and ethnic differences in plasma phosphorylated tau 217 percentage (%p-tau217) may influence screening eligibility. Objective To characterize racial...

Exploring transcriptomic and genomic latent variable correction approaches in differential expression analysis

Abstract Background Differential expression analysis is a central tool for studying the biological processes altered in human diseases via transcriptomic signatures. However, transcriptomic datasets are systematically confounded by latent variables from two distinct sources: unme...

Transforming federal emergency management: a new agenda for Canada

Abstract Canada’s emergency governance model no longer aligns with a risk environment shaped by accelerating climate change and increasingly complex multi-hazard events. Recent federal/provincial/territorial strategies acknowledge these growing pressures but have not materially r...

Ultrafast Magneto‐Geometric Control of Terahertz Helicity in Curved Ni Metasurfaces

ABSTRACT Dynamic helicity control in the terahertz (THz) regime is essential for ultrafast polarization optics, chiral spectroscopy, and polarization‐selective photonic devices, yet remains difficult because most THz chiral systems are structurally fixed or rely on slow external...

Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies

ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as...

Gaps in diabetes care among people living with HIV and hypertension in Botswana: A cross‐sectional analysis of the InterCARE study

Abstract Objectives Data on diabetes screening and monitoring, within HIV care programmes in sub‐Saharan Africa, remain limited. This study describes the quality of diabetes screening and management among people living with HIV with comorbid hypertension receiving care at facilit...