Harvard University

Microbial Network Signatures Associated With Outcomes of Peri‐Implantitis Therapy

ABSTRACT Aim To investigate the microbial network signatures associated with outcomes following surgical therapy of peri‐implantitis. Materials and Methods Microbiological data from a 1‐year randomised controlled trial of 28 patients (28 implants) were analysed. Based on a compos...

Systemic RVX ‐208 Attenuates Experimental Periodontitis Through Inflammatory Host Modulation

AIMS: This study investigated whether systemic treatment of RVX-208, a selective BET protein inhibitor, could ameliorate experimental periodontitis in a prophylactic setting and examined transcriptomic changes associated with RVX-208 in vitro. METHODS: Porphyromonas gingivalis (P...

Left Ventricular Structural, Physiological, and Transcriptomic Abnormalities in a Novel Porcine Hypertrophic Cardiomyopathy Model

sensitivity. The cardiac myosin inhibitor MYK-581 reduced hypercontractility and improved diastolic function. Data from this large animal genetic model of HCM strengthen the mechanistic link between genetic variants and in vivo phenotypes and elucidate the mechanisms of myofilame...

Needle-Related Procedural Pain: An Integrated Nervous-System Framework from Tissue Mechanics to Central Processing—A Systematic Review

Background/Objectives: Needle procedures cause acute pain through mechanical, chemical, sensory, and affective processes. We synthesized human and animal evidence and developed a framework spanning peripheral nociception, spinal/trigeminal modulation, central processing, and clin...

HIV transmission behaviors, detectable HIV-RNA and curable STI prevalence among Ugandan men with HIV with reproductive goals, with and without infertility experiences

Many men with HIV (MWH) want children. MWH with unmet reproductive goals may prioritize conception over preventing HIV/STI transmission. Therefore, we evaluated whether MWH with unmet versus met reproductive goals were more likely to have detectable HIV-RNA or STIs, and explored...

The structural context of mutations in proteins predicts their effect on antibiotic resistance

Abstract In Mycobacterium tuberculosis, a prevalent and deadly pathogen, resistance to antibiotics evolves primarily through non-synonymous mutations in proteins. Sequence-based analyses are currently used to understand the genetic basis of antibiotic resistance, either via genot...

Removing Tuition Dependency From Dental Education: Consensus Recommendations on Student Debt, Sustainability, and Pathway Reform

BACKGROUND: The current financing model for US dental education is increasingly misaligned with the goals of sustainability, equity, and workforce design. Tuition has risen substantially over time, educational debt among dental graduates remains high, and evidence suggests that p...

Lymph node contraction links sex-biased naive CD8+ T cell decline to compromised antigen recognition during middle age

Abstract The abundance of diverse naive CD8 + T cell clones is essential for broad protection against infection and cancer, but how sex and aging jointly shape this compartment remains poorly understood. Here, using mouse models with supporting human data, we uncover a sex-biased...

Surgical Management Patterns and Outcomes in Recurrent Corneal Erosion: An IRIS Registry Study

PURPOSE: Surgical management of recurrent corneal erosion (RCE) lacks large-scale evidence, and national patterns of care and procedural outcomes remain incompletely defined. We characterized national practice patterns, repeat surgery rates, and risk factors for surgical failure...

Tobacco use moderates associations between cannabis use, psychiatric symptoms, and cognitive performance in psychosis spectrum disorders

Tobacco and cannabis use are highly prevalent among individuals with psychotic disorders. Tobacco use has been consistently linked to poorer clinical and cognitive outcomes, whereas findings regarding cannabis use remain mixed. The present study was a secondary analysis of cross-...

A Community-Based Behavioral Intervention and Body Mass Index in School-Aged Children

Importance Childhood obesity remains a major concern in the US, with increases in body mass index (BMI) observed during and after the COVID-19 pandemic. Scalable behavioral interventions are needed to support obesity prevention in community settings. Objective To evaluate the eff...

Coupling target and radioactive emitter matters: a sub-tissue dosimetric study to identify optimal strategies

Abstract Background Radiopharmaceutical-therapy dosimetry depends on both radionuclide emission physics and the spatial distribution of activity. We evaluated how radionuclide identity and protein-defined subcellular localization influenced cancer-cell nuclear absorbed-dose distr...

Hypoxia and right ventricular dysfunction in patients with acute pulmonary embolism

In patients with acute pulmonary embolism (PE), hypoxia may increase pulmonary vascular resistance and worsen right ventricular dysfunction (RVD), which is a key prognostic factor. However, associations between hypoxia, RVD and clinical outcomes have not been well described. To d...

Validation of the International Working Group 2023 response criteria for higher risk myelodysplastic syndromes/neoplasms using the International Consortium for Myelodysplastic Syndromes VALIDATE database and a randomized phase III trial

Response assessment criteria in patients with higher-risk myelodysplastic syndromes/neoplasms (HR-MDS) have been updated in the 2023 International Working Group (IWG) criteria. However, validation of these criteria has been limited to date. We analyzed overall survival (OS) by be...

Rigorous Evaluation of Microarchitectural Side-Channels with Statistical Model Checking

Rigorous quantitative evaluation of microarchitectural side channels is challenging for two reasons. First, the processors, attacks, and defenses often exhibit probabilistic behaviors. These probabilistic behaviors arise due to natural noise in systems (e.g., from co-running proc...

Tobacco Use is Associated with Anorectal Sensorimotor Dysfunction and Greater Fecal Incontinence Severity

Background: Tobacco use has been associated with a range of digestive symptoms and gastrointestinal smooth muscle dysfunction. However, the impact of tobacco use on fecal incontinence (FI) and anorectal function remains unclear. We aimed to evaluate whether tobacco use disrupts a...

Beyond the ‘Big Three’: Prospective Associations Between Cumulative Lifestyle Protective Factors and Subsequent Adolescent Wellbeing

ABSTRACT Introduction Lifestyle factors are increasingly recognized as important correlates of adolescent mental health and wellbeing. However, existing research has largely focused on sleep, nutrition, and physical activity in isolation, with less attention to cumulative multido...

High-fidelity entangling gates and nonlocal circuits with neutral atoms

The generation and manipulation of entanglement with low error are essential in quantum information systems. In practice, two-qubit entangling gates constitute a dominant error source, limiting circuit depths and performance in fault-tolerant architectures. Using a neutral-atom q...

Longitudinal Trends and Characteristics of Hospital Closures and Openings

This study assesses hospital closures and openings from 2010-2025 to characterize net changes in hospitals and beds, factors associated with closures and openings, and changes in distance to the nearest hospital after closures.

Entropic Optimal Transport Eigenmaps for Nonlinear Alignment and Joint Embedding of High-Dimensional Datasets

Abstract. Embedding high-dimensional data into a low-dimensional space is an indispensable component of data analysis. In numerous applications, it is necessary to align and jointly embed multiple datasets from different studies or experimental conditions. Such datasets may share...