Harvard University

MitoGPS: A Mitochondrial DNA G‐Quadruplex‐Targeting Strategy for Tumor‐Preferential Type I Photodynamic Therapy

ABSTRACT Photodynamic therapy (PDT) is a clinically promising, minimally invasive cancer treatment offering precise spatiotemporal control. However, achieving preferential tumor accumulation remains a critical challenge, which limits therapeutic efficacy and induces off‐target to...

The effects of royal jelly consumption on glycemia indices, lipid profile, and blood pressure in patients with acute ischemic stroke: a randomized, triple-blind trial

Abstract Aims The effects of royal jelly (RJ) on cardiometabolic risk factors in patients with acute ischemic stroke have not been previously reported from this trial. Therefore, we conducted a secondary analysis to investigate the effects of RJ consumption on glycemic indices, l...

Metabolomic profiling reveals distinct and shared biology in COPD and IPF

Chronic Obstructive Pulmonary disease (COPD) and Idiopathic Pulmonary Fibrosis (IPF) are chronic pulmonary disorders with distinct pathologies but shared risk factors. Metabolomics may provide insights into mechanisms. To identify metabolites associated with COPD and IPF, and to...

Longitudinal digital phenotyping of activity rhythms and biological aging using commercial wearables

Abstract Disrupted rest-activity rhythms have been associated with aging and chronic disease, yet longitudinal evidence from free-living populations has been lacking. Here we integrate multi-year Fitbit activity data from the All of Us Research Program with clinical biomarker-der...

Quantifying the Acute Toxicity of Alpha-Synuclein Membrane-Accumulation in a Cell-Based Assay

Abstract Parkinson’s disease (PD) is a progressive neurodegenerative disorder that affects over 12 million people worldwide. A central pathological feature is the accumulation of aggregated alpha-synuclein (αS) in Lewy bodies and Lewy neurites. Engineered αS variants such as 3K (...

Prediagnostic circulating 25-hydroxyvitamin D and prostate cancer-specific survival: a collaborative pooled analysis of 13 prospective studies

Abstract Background Previous research suggests higher risk of prostate cancer diagnosis in men with high vitamin D serology, but there are limited data related to prostate cancer survival. In this study, we examine the associations between prediagnostic circulating levels of 25-h...

Management of Acute Pulmonary Embolism in a Patient With Hereditary Factor X Deficiency

All authors declare that they have no conflicts of interest. The data that support the findings of this study are available from the corresponding author upon reasonable request.

“I Just Need Guidance Through This Maze I’m Going Through”: Addressing Unmet Basic and Mental Health Needs to Facilitate Engagement in HIV Prevention Services in the Context of Stimulant Use

There is a global syndemic of HIV, mental health challenges, substance use, and structural barriers. Critical to local HIV prevention efforts is understanding this syndemic in the context of rising stimulant use to inform intervention development. Adhering to the EPIS model, we c...

A comparative “report card” wellbeing assessment of 22 countries in the Global Flourishing Study

When evaluating how countries are faring, there is a widespread tendency to rely on single metrics or indices, whether objective (e.g., GDP) or subjective (e.g., life evaluation). However, flourishing is multidimensional, and societies invariably do better in some ways and less s...

Early gastric carcinoma with lymphoid stroma associated with a low risk of lymph node metastasis and favorable prognosis: a multicenter study in a Chinese population

Abstract Objective Gastric carcinoma with lymphoid stroma is a rare subtype of gastric carcinoma. The clinicopathological features and prognosis of early gastric carcinoma with lymphoid stroma (EGCLS) remain elusive, especially in Chinese populations. Methods In this study, we in...

Automated alveolar bone and teeth 3D segmentation on the cone-beam computed tomographic images using the convolutional neural network

Abstract Background Cone-beam computed tomography (CBCT) is widely used in dental diagnosis and implant planning. The accurate segmentation of teeth and alveolar bone from CBCT images is essential for precise diagnosis and treatment planning. In this study, we propose two distinc...

Leveraging the private sector for health system development in sub-Saharan Africa

Development assistance has historically supported major gains in health and health-system development in sub-Saharan Africa, but recent reductions in development assistance have intensified financing and service-delivery pressures across the region. As governments seek more durab...

δ2-Protocadherins organize parallel indirect basal ganglia circuits

Abstract The basal ganglia (BG) contain multiple parallel neural circuits, each of which may control different behaviors. However, how the distinct parallel BG circuits are molecularly organized is not known. Here we show that two δ2-protocadherins (PCDHs), PCDH17 and PCDH10, whi...

Responsiveness of epigenetic aging biomarkers to longevity interventions in humans

Abstract Aging biomarkers can potentially allow researchers to rapidly monitor the impact of an aging intervention without the need for decade-spanning trials. However, before the use of aging biomarkers, such as epigenetic clocks, as surrogate endpoints, their responsiveness to...

Chronic stress disrupts the network among stress granules, P-bodies, and motor proteins

Stress granules (SGs) are dynamic RNA condensates that assemble rapidly in response to cellular stress following translational arrest, thereby promoting adaptation and influencing disease pathogenesis. Although SG assembly and disassembly during acute stress have been extensively...

Differential associations between social determinants of health and the initiation of medications for opioid use disorder across care settings

Abstract Objective This study investigated associations between social determinants of health (SDoH) and time to MOUD initiation across care settings, providing insights for targeted interventions to promote equitable care for OUD patients. Material and Methods We linked patient-...

Hypoxia-activated scleraxis a mediates epicardial progenitor differentiation into a unique cardiac perivascular cell type

Abstract The epicardium is a crucial source of progenitor cells and paracrine signals that support heart development and regeneration. However, the molecular mechanisms that guide epicardial cell fate decisions remain incompletely understood. Here, we identify the transcription f...

A Hybrid Transfer Learning Approach for Ambient PM2.5 Exposure Modeling in LMIC Contexts: A Case Study from Lima, Peru

Abstract Exposure to fine particulate matter (PM2.5) contributes to millions of premature deaths annually worldwide. While epidemiological studies increasingly rely on geospatial technologies, such as satellite remote sensing, low-cost sensors, and chemical transport models, to q...

Early improvement in depressive symptoms after pallidothalamic tract deep brain stimulation for drug-induced dystonia

Stimulation for lithium-induced dystoniaLong-term exposure to psychotropic agents, including lithium and dopamine D2/D3 partial agonists such as brexpiprazole, has been associated with delayed and sometimes persistent

Paediatric therapeutic development workshop on osteosarcoma

The fourth Paediatric Therapeutic Development Workshop focused on osteosarcoma, the most common primary bone cancer in children and young adults. Current treatment of osteosarcoma comprises surgery and chemotherapy. Outcome has shown very little improvement over the last four dec...