Harvard University

Children’s health before, during, and after parental/caregiver immigration detention in the United States: findings from a cross-sectional survey

Background Parental immigration detention is a significant yet understudied stressor with potential consequences for children's well-being. We examined children's general health before, during, and after parental detention, and compared to the United States (US) pediatric populat...

‘Intelligence’ in function but not in name: analyzing terminology and trends in the job market

Abstract Private sector intelligence uses a vast array of terminology that obscures the boundaries, clear definition and demarcation of the field. This paper presents original empirical research to analyze job responsibilities and terminology. It first examines 2245 job postings...

Gout May Mimic Infection, Even Years After Achilles Tendon Repair

BACKGROUND: Gout can affect tendons in addition to joints and may clinically resemble infection. The resulting diagnostic uncertainty may lead to surgical intervention or antibiotic treatment, even in patients whose symptoms might be managed medically if gout is recognized earlie...

Prognostic Significance of Contrast Enhancement in Newly Diagnosed Grade 2 IDH-mutant Glioma

Abstract Background Contrast enhancement is generally considered an adverse prognostic feature in adult glioma. However, its significance in newly diagnosed grade 2 IDH-mutant glioma remains uncertain, with important implications for use of the mutant IDH inhibitor vorasidenib. W...

Hidden or undetected? Quantifying the boundary between structural bias and statistical noise in peer review

Purpose Peer review shapes not only the evaluation of scientific claims but also whose work gains visibility and influence. A growing body of evidence shows that review outcomes can mirror structural inequities tied to authors' identities, language backgrounds, institutional posi...

Schizophrenia research in 2026: report from the annual meeting of the Schizophrenia International Research Society

Abstract SIRS 2026, held under the theme “Schizophrenia Research in the Era of Artificial Intelligence,” brought together researchers, clinicians, and persons with lived experience to take stock of a field whose tools for measuring, predicting, and intervening in psychosis have e...

Associations of food processing and dietary risk factors with colorectal cancer incidence in the NIH-AARP Diet and Health Study: A cohort study

Background Ultra-processed foods (UPF) account for >50% of energy intake by US adults. UPF intake can include dietary components linked to lower colorectal cancer (CRC) risk, such as whole grain and dairy products, and others linked to higher CRC risk, such as processed meats, po...

The Reflection Penalty: when managers accept leadership coaching from a human but not an AI agent

Leadership coaching develops managers but is expensive and difficult to scale. AI may be able to help scale access, but “answering machine” like AI coaching agents invite cognitive offloading and weaken learning. We instantiated a human coaching protocol, supported across prior c...

Characterizing In-Home Safety Challenges and Strategies for Children With Medical Complexity

OBJECTIVES: Medical advances have allowed more children with medical complexity (CMC) to live at home, but previous research has linked implanted tubes to patient safety events. We aimed to characterize challenges and strategies parents use to deliver their children's tube-relate...

The Challenges of Linking SNAP State Cost Sharing to Payment Error Rates

This JAMA Forum discusses changes to the Supplemental Nutrition Assistance Program (SNAP) after passage of HR 1, the complexity of calculating payment error rates in the program, and the consequences of linking these rates to state cost sharing.

National statistical organizations at a crossroads: Trust, independence, and democratic relevance in the AI Era

National Statistical Offices (NSOs) were established to serve essential state functions—taxation, mobilization, and administrative governance—but evolved into professional institutions that safeguard the public interest through impartial statistics. Today, despite sustained moder...

Clinician Use of an Artificial Intelligence–Enabled Clinical Information Platform

Importance Despite growing interest in the use of artificial intelligence (AI) in medicine, empirical evidence on how clinicians use these tools is limited. Objective To characterize clinician use of an AI-enabled clinical information platform, the distribution of use across the...

Development of a Potent and Isoform-Selective HDAC11 Inhibitor with Anti-Tumor Efficacy against Non-Small Cell Lung Cancer

Abstract Targeting histone deacetylase 11 (HDAC11) represents a promising therapeutic strategy, yet developing selective inhibitors for solid tumors remains a formidable challenge. Herein, we describe the rational lead optimization of a novel series of indole-based hydroxamic aci...

Irkutsk: Russian lab death demands verification

A laboratory worker’s death from unexplained pneumonia exposes how little information is known and shared about high risk pathogen work, writes Ashish Jha

Human-in-the-loop large language model framework for identification of cutaneous immune-related adverse events

This study evaluated a retrieval-augmented, multi-agent large language model (LLM)–driven, human-in-the-loop framework for detecting cutaneous immune-related adverse events (cirAEs) from clinical notes. Compared with the unassisted manual-review group, the LLM-assisted group demo...

Hemispheric Asymmetry of Neuroimaging Biomarkers in Early Onset Alzheimer's Disease: Clinical and Cognitive Outcomes

Objective Individuals diagnosed with Alzheimer's disease (AD) often exhibit amyloid, tau, and atrophy predominantly in the left or right hemisphere, but group‐level analyses typically ignore inter‐individual variability and changing asymmetry patterns when averaging data across p...

Why do some Latin American countries flourish despite material constraints? Insights from the Global Flourishing Study

The Latin American region faces ongoing challenges related to disease burden, healthcare inequalities, and constraints on quality of life.1 Despite these structural barriers, countries in this region often score higher on subjective indicators of well-being (e.g., life evaluation...

Support or Simplicity: Evaluating Mesh Use in Two-Stage Prepectoral Breast Reconstruction

Background: The routine use of surgical mesh in prepectoral two-stage breast reconstruction has increased despite limited high-level evidence supporting its necessity. The purpose of this study was to evaluate whether mesh use impacts postoperative complications, reconstructive f...

Morphology and Ion Transport in Zwitterionic Polysiloxanes

Abstract The recent discovery of superionic conductivity in doped polyzwitterions (PZIs) has opened a new direction for polymer electrolytes (PEs). Solid-state battery research is currently dominated by inorganic electrolytes due to their rigidity and high conductivity, but they...

Patient-Reported Changes in Alcohol Use Following Glucagon-Like Peptide-1 Receptor Agonist Initiation

This survey study with a nationally representative sample evaluates whether individuals who initiate glucagon-like peptide-1 receptor agonists (GLP-1 RAs) report reducing alcohol consumption after starting the drug.