Columbia University

An iron-regulated methionine redox axis governs adipose browning and cancer cachexia

Abstract Adipose browning and atrophy are early events of cachexia, a lethal metabolic disorder affecting nearly half of the population with cancer. Here, using individual-derived specimens and mouse models, we identified an iron-dependent pathway that initiates adipose browning...

The Cold-Air Outbreaks in the Marine Boundary Layer Experiment model-observation intercomparison project (COMBLE-MIP) – Part 1: Model specification, observational constraints, and preliminary findings

Models struggle to represent the coupled microphysical, turbulent and radiative processes within widespread, long-lived marine cold-air outbreak (CAO) cloud fields, contributing to forecast and climate biases. Here we combine ground-based and satellite measurements to initialize...

“There was no parenting class for this”: Gendered experiences of navigating the empty nest transition

This research aims to enhance understanding of the empty-nest transition and the diverse experiences parents undergo during this period. While the transition into parenthood has been extensively studied, the shift into post-parenting life, when children leave the household, remai...

Early gait segments may be sufficient: fall risk assessment does not require steady-state walking

Falls remain a significant health concern for older adults, highlighting the need for efficient and accurate fall risk screening. Although wearable inertial measurement units provide accessible gait analysis, it remains unclear whether fall-history classification requires gait pa...

Does despair drive increases in white mortality, or did the narrative get ahead of the data?

The aim of this study is to test the central claim of the "deaths of despair" theory: that rising despair among midlife white Americans has driven increases in all-cause mortality, particularly in those with low education. We analyzed time series of annual all-cause mortality rat...

Portable Low-Field MRI of the Brain in Clinic and Community Settings

This cohort study evaluates portable, low-field magnetic resonance imaging (MRI) against conventional MRI in memory clinic and community cohorts.

RamanOmics decodes the spatial vibrational–molecular architecture of senescence in aging and repair

Aging and tissue repair involve heterogeneous remodeling across transcriptional, biochemical and cellular dimensions, yet prevailing definitions rely on isolated molecular markers that obscure how these states co-evolve. Here we present RamanOmics, a multimodal framework integrat...

Construction and characterisation of the DarkSide-20k veto silicon photo-multiplier tiles

Abstract Silicon photo-multipliers (SiPMs) are state-of-the-art sensors capable of detecting a single photoelectron under cryogenic conditions, with potentially lower radioactivity than widely used photomultiplier tubes. The DarkSide-20k experiment, designed to perform direct dar...

Future Redistribution of North Atlantic Tropical Cyclone Risk in Two Contrasting CMIP6 Scenarios

Abstract We analyze North Atlantic Tropical Cyclone (TC) activity using the Columbia HAZard model to downscale 12 models from CMIP6 under the SSP1‐2.6 and SSP5‐8.5 scenarios—representing low and high radiative forcing, respectively. Despite greater warming under SSP5‐8.5, basin‐w...

Predicting measles outbreak magnitude via modeled population susceptibility evidence from pre-vaccination data

We characterized pre-vaccination measles dynamics using a discrete-time mechanistic model that integrates incidence time series and demographic data to estimate key epidemiological parameters and to quantify the relationship between the reconstructed population susceptibility and...

Organizational determinants of burnout among hospital‐based nurse practitioners: A structural equation modeling analysis

Abstract Background The nurse practitioner (NP) workforce is rapidly expanding in hospital settings, yet limited evidence exists on how organizational practice environments influence NP burnout. Identifying modifiable workplace factors is critical to improving NP well‐being and r...

The psychological impact of traumatic invalidation among U.S. Jewish adults after October 7, 2023

This study examined traumatic invalidation (TI), the extreme dismissal of an individual’s experiences, characteristics, or beliefs, specifically in the Jewish community. We investigated the prevalence and psychological impact of identity-based TI among 733 Jewish adults in the Un...

PriME: Privacy-Aware Membership Profile Estimation in Networks

Abstract. This paper presents a novel approach to estimating communbity membership probabilities for network vertices generated by the degree corrected mixed membership stochastic lock model [ 36 ] while preserving individual edge privacy. Operating within the [Formula: see text]...

Mental disorders, service use, and perceived treatment need among college students after the COVID-19 pandemic and the role of social connection: an epidemiological study

Abstract Background College students affected by mental disorders can be very impaired; yet, treatment rates remain low. The COVID-19 pandemic undoubtably posed strain on students, limiting their social life, which is an important determinant of health. However, recent estimates...

How Much Physics Should a Neural Network Know? Thermodynamics‐Informed Neural Networks for Rock Constitutive Modeling With Epistemic Uncertainty

Abstract Machine learning offers a flexible route to constitutive modeling, with two emergent questions for geoscience applications: what level of thermodynamic constraint should be embedded in the network architecture, and how should predictive uncertainty be quantified when ext...

Trends in Pediatric Urology Resident Operative Exposure and Autonomy: An 11-Year National Study

PURPOSE: Fewer urology residents are pursuing pediatric urology fellowship. Studies have examined potential associations between surgical residents' operative experience, autonomy, and exposure and fellowship pursuit. This relationship has not been examined with respect to pediat...

The Growing Need to Address Mental Health Vulnerabilities to Artificial Intelligence

Use of artificial intelligence (AI) may be contributing to mental health problems, including delusions, but reports to date have largely been anecdotal and focused on users with prior psychiatric diagnoses. Crucial questions remain with regard to the prevalence, types, predictors...

Engineering Metal Nanomaterials for Precision Genetic Medicine

ABSTRACT Genetic medicine has established a transformative paradigm for precision therapy. To date, most advances have relied on viral vectors and non‐viral lipidic and polymeric nanocarriers. Although metal nanomaterials have not achieved clinical approval for gene therapy, rece...

Academic medical centers implementing new Medical Aid in Dying (MAiD) laws: challenges and solutions

New York and additional jurisdictions are now joining others in legalizing Medical Aid in Dying (MAiD), but academic medical centers and clinicians are, consequently, confronting dilemmas regarding whether to provide it, and if so, how. Institutions must decide what processes to...

Spin effects in superfluidity, neutron matter, and neutron stars

We review selected aspects of the interior physics of compact stars, focusing on the microscopic and macroscopic manifestations of spin, magnetic fields, and nucleonic superfluidity and superconductivity. Spin statistics of fermions allow quantum degeneracy pressure to determine...