Columbia University

Manipulation-Robust Prediction

An increasing number of decisions are guided by machine learning algorithms. But when consequential decisions are encoded in algorithms, individuals may strategically alter their behavior to achieve desired outcomes. This paper develops an empirical approach that adjusts decision...

Therapeutic alliance across delivery modalities: a systematic narrative review of alliance strength and outcome prediction in face-to-face, online, and blended psychotherapy

The frequency of online psychotherapy, including pure online (PO: videoconference [PO-VC], telephone [PO-TEL], asynchronous therapist-guided [PO-Async]), or blended (BLD) modalities, has grown exponentially, yet how the therapeutic alliance (TA), a key outcome predictor, compares...

Barriers and facilitators to integrating mental health and psychosocial support into economic inclusion programming for displaced families in ecuador

Abstract Background Displaced populations have increased rates of mental health problems, which have been shown to have a bidirectional relationship with economic insecurity. Despite growing calls globally to integrate mental health and psychosocial support (MHPSS) with economic...

All-optical multimodal mapping of single-cell-type-specific metabolic activities via REDCAT

Abstract Metabolism is fundamental to cell function, yet its activities vary across tissue environments. Resolving these processes in situ at single-cell resolution is crucial for understanding physiology in health and disease. However, existing methods lack biochemical specifici...

International migration of Africa-born health workers: a scoping review of drivers and policies, 2010–2024

Africa faces a critical shortage of human resources for health (HRH), crucial for improving population health. We described drivers of and policies to manage the migration of Africa-born HRH from source (African) countries in Africa to destination (non-African) countries. We cond...

Intracranial delivery of neuron-preferential lipid nanoparticles for gene-editing activity in mouse brain

Lipid nanoparticles (LNPs) are promising non-viral vectors for central nervous system (CNS) gene therapy, but effective delivery is limited by the blood-brain barrier and cell-type specificity. Here, we combined intracranial delivery with high-throughput, cluster-based screening...

Prefoldin function links meiotic chromosome segregation with cellular remodeling and reveals tubulin sensitivity of the meiotic spindle

Abstract Faithful chromosome segregation is essential for producing viable gametes during meiosis, a specialized type of cell division compared to mitosis. Unlike mitosis, meiosis involves two consecutive chromosome segregation events without an intervening round of DNA replicati...

Proteomic Immune Signatures of Severe HIV-Associated Tuberculosis in Sub-Saharan Africa: A Prospective, Multicenter Analysis From Uganda

Abstract Objective Severe tuberculosis (TB) is a major cause of critical illness and death in people living with HIV (PLWH) worldwide. Despite this, the immunopathology of severe HIV-associated TB (HIV/TB) is poorly understood. We aimed to identify an immunopathologic signature o...

Optotagging in primate cortex uncovers excitatory and inhibitory neuron specializations in form vision

Abstract The perception of complex visual shapes is a hallmark of primates and a foundation for many of their decisions and actions. The neural mechanisms of this visual function are best studied in macaques, but progress in this animal model has been hampered by the inability to...

Effect of electron cyclotron waves on plasma with runaway electrons

Abstract Runaway electrons generated during tokamak disruptions are a major concern for the safe operation of future fusion devices. The interaction of runaway electrons with waves has been proposed as a potential mechanism for their mitigation. This study investigates the effect...

Bayesian Neural Networks versus deep ensembles for uncertainty quantification in machine learning interatomic potentials

Abstract Neural-network-based machine learning interatomic potentials have emerged as powerful tools for predicting atomic energies and forces, enabling accurate and efficient simulations in atomistic modeling. A key limitation of traditional deep learning approaches, however, is...

Transposon end recognition and excision mechanisms of type I-F CRISPR-associated transposases

Abstract CRISPR-associated transposons (CASTs) are Tn7-like elements that have co-opted RNA-guided CRISPR effectors for targeted DNA insertion. CASTs have been adapted as genome editing tools for programmable, site-specific integration. Among them, the type I-F system from Ps e u...

Care Team Response to Patient Portal Message Content and Writing Style

Importance Patient portal messages are an increasingly central channel for patient-clinician communication, but there are inequities in how responsive care teams are to messages sent by patients from historically marginalized groups. The reasons driving these disparities are not...

Multilevel factors influencing HIV care and management in the Deep South: insights from HIV care professionals

The United States Deep South bears a disproportionate HIV burden, with low rates of retention in care and viral suppression among people living with HIV (PWH). Factors influencing HIV care engagement can be understood through the modified social ecological model (MSEM), which com...

Navigating physician-scientist careers: insights from American Board of Internal Medicine Research Pathway graduates

The American Board of Internal Medicine Research Pathway (ABIM RP) is designed to train physician-scientists by shortening postgraduate clinical training and increasing research time. We surveyed ABIM RP graduates to understand career trajectories, research engagement, and barrie...

Dual-oxygen pancreatic cancer organoids recapitulate basal–classical heterogeneity validated by spatial transcriptomics

Pancreatic ductal adenocarcinoma (PDAC) comprises heterogeneous classical and basal-like subtypes. Although pancreatic cancer organoids (PCOs) are widely used, normoxic cultures preferentially maintain the classical subtype, limiting their ability to represent intrinsic intratumo...

The clinical and molecular spectrum of AGO2-associated Lessel-Kreienkamp neurodevelopmental syndrome

Abstract Background Pathogenic variants in AGO2 ,encoding a central component of the RNA-induced silencing complex (RISC), cause the neurodevelopmental disorder Lessel-Kreienkamp syndrome (LESKRES). The variant spectrum and associated molecular mechanisms underlying phenotypic va...

Benchmarking generative AI tools for literature retrieval and summarization in genomic variant interpretation

Abstract Background Generative AI is increasingly used to extract structured information across domains, but its reliability in academic and clinical research, where precision and accuracy are essential, remains largely unexplored. This study evaluates the ability of Large Langua...

Feasibility and acceptability of adding peer support to a school-based nurse-led smoking cessation intervention among male adolescents in Pakistan: a pilot cluster-randomized trial

Reducing adolescent smoking is a global health priority. School-based, nurse-led interventions show promise, yet most studies have been conducted in Western and other high-income countries. This study assessed the feasibility and acceptability of a school-based, nurse-led smoking...

Bayesian inference of lineage trees by joint analysis of single-cell multimodal lineage-tracing data with BiLinT

Abstract The advent of single-cell lineage-tracing technologies has enabled simultaneous measurement of gene expression and lineage barcodes. However, integrating these modalities for high-resolution lineage reconstruction has remained challenging due to limitations of methods th...