Yale University

Multisoliton Solutions and Blow Up for the $$L^2$$-Critical Hartree Equation

Abstract We construct multisoliton solutions for the $$L^2$$ L 2 -critical Hartree equation with trajectories asymptotically obeying a many-body law for an inverse square potential. More precisely, we consider the m -body hyperbolic and parabolic non-trapped dynamics. The pseudo-...

Cardiometabolic Benefits and Risks for Transgender Youth with the Initiation of Gender-Affirming Hormone Therapy: a case series

Background. Interventions for transgender youth include puberty suppression and gender affirming hormone therapy (GAHT). Studies have begun to show changes in cardiometabolic outcomes in adolescent transgender males (TGM) and females (TGF). We hypothesized that in TGM and TGF you...

Management coverage and spatial gaps for carnivore habitat across Mexico

Abstract Area‐based conservation is central to global wildlife protection. In Mexico, a mosaic of land management types beyond traditional protected areas (PAs), including voluntary conservation areas (VCAs), wildlife management units (UMAs), and Indigenous Territories (ITs), may...

HIPPIE: a generative model for electrophysiological analysis across species, technologies, and modalities

Abstract Neuronal classification from extracellular electrophysiological recordings is challenging due to intrinsic waveform variability, noise, and technical differences across experiments, technologies, and species. We introduce HIPPIE (High-dimensional Interpretation of Physio...

Responsiveness of epigenetic aging biomarkers to longevity interventions in humans

Abstract Aging biomarkers can potentially allow researchers to rapidly monitor the impact of an aging intervention without the need for decade-spanning trials. However, before the use of aging biomarkers, such as epigenetic clocks, as surrogate endpoints, their responsiveness to...

Structural causal influence captures the forces of social inequality in models of infectious disease

Abstract Mathematical models are central to understanding disease transmission for host–pathogen systems across the biosphere. However, most existing frameworks do not explicitly treat host population heterogeneity as a formal driver of variation in transmission dynamics. This ga...

Corticolimbic structure-function coupling is sensitive to childhood adversity and buffers adversity-related symptoms during development

Abstract Childhood adversity is a potent predictor of mental health problems across the lifespan, and a rich cross-species literature implicates stress-sensitive corticolimbic circuits in adversity-related psychopathology. Structure-function coupling (SFC) is a promising multimod...

SPINK1-COL18A1 crosstalk shapes epigenome and drives cancer stemness in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is a devastating cancer with an increasing incidence and extremely dismal prognosis. Discovery and mechanistic understanding of the genetic and epigenetic drivers of PDAC is therefore of critical importance. Here, we uncover serine protease...

Modern endoscopic strategies for the diagnosis and management of cholangiocarcinoma

Cholangiocarcinoma (CCA) presents considerable diagnostic and therapeutic challenges for the endoscopist. This review offers a focused and practical evaluation of contemporary endoscopic approaches for the diagnosis and management of CCA, with an emphasis on real-world applicabil...

Thoracic ligamentum flavum ossification causing progressive myelopathy: a case report

Background: Ossified ligamentum flavum (OLF) in the thoracic segments is a rare but significant cause of progressive myelopathy characterized by spinal canal stenosis. While OLF is commonly reported in East Asian populations, it remains under-recognized in other regions, includin...

Optimizing culture-free approaches to recover high-quality Mycobacterium tuberculosis genomic variation

Background. Mycobacterium tuberculosis ( Mtb ) genomic epidemiology often relies on culturing patient sputum, a time- and labour-intensive process. Hybrid capture approaches have been successfully used to enrich Mtb DNA from complex clinical samples, yet the accuracy of variant i...

Time-dependent divergence in infection risks among patients with multiple sclerosis treated with fumarates versus anti-CD20 monoclonal antibodies

Background: People with multiple sclerosis (pwMS) treated with anti-CD20 monoclonal antibodies have an elevated infection risk, yet long-term comparative data with oral fumarates are limited. Objective: To compare infection incidence, healthcare resource utilization, and relapse...

Laser Interstitial Thermal Therapy for Brain Tumors: A Prospective Multicenter Analysis of Patients From the LAANTERN Study

Background: Laser interstitial thermal therapy is a surgical tool used to ablate brain tumors, radiation necrosis, and epileptic foci. Data from the completed LAANTERN prospective multicenter registry (NCT02392078), containing tumor patients enrolled in the study across 25 US cen...

Quantifying the Burden of Cerebellar and Ophthalmologic Disease in Lambdoid Craniosynostosis

OBJECTIVE: Lambdoid craniosynostosis may restrict posterior brain development, particularly involving the cerebellum and occipital lobe, with potential implications for vision and balance. However, due to its rarity, evidence linking lambdoid craniosynostosis to adverse ophthalmo...

Rare variant effect estimation and polygenic risk prediction

Abstract Due to their low frequency, estimating the effect of rare variants is challenging. Here, we propose RareEffect, a method that first estimates gene- or region-based heritability and then each variant effect size using an empirical Bayes approach. Our method uses a varianc...

Trait Plasticity in Herbivore Populations Maintains Geographic Patterns of Herbivory on a Dominant Plant Species Under Warming

ABSTRACT Across species' geographic ranges, local populations may enlist behavioral, physiological, and morphological plasticity together to cope with stress from changing thermal conditions. But if local populations cannot sufficiently adjust their phenotype, then they may fail...

Beyond Immediate Responses: A Systems Map of Community Factors Underlying Persistent Gun Violence in New Haven

Abstract Gun violence is a pervasive and multifaceted public health problem. This study describes a novel application of group model building—a process that centers stakeholder voices to describe a complex problem—to investigate drivers of gun violence and design community-led in...

The Case for a Gap between Verdict and Sentencing at Court-Martial

Abstract The military is the only American jurisdiction that nearly always proceeds immediately from a verdict of guilt to the imposition of punishment. This compressed timeline produces a self-reinforcing dynamic: Because counsel lack the time to develop detailed factual records...

DOSE: An open-source, iOS watch-based tool for experience sampling

Smartwatches facilitate low-burden rapid-access micro-interactions, making them ideal for Experience Sampling Methods (ESMs). Despite the Apple Watch being the most popular smartwatch in the U.S., it has yet to be utilized in ESM studies due to a lack of accessible frameworks tha...

RobustCell: a model attack-defense framework for robust transcriptomic data analysis

Abstract Computational methods should be accurate and robust for tasks in biology and medicine, especially when facing different types of attacks, defined as perturbations of benign data that can cause a significant drop in method performance. Therefore, there is a need for robus...