Wuhan University

The global cardiovascular-kidney-liver-metabolic burden from 1990 to 2023

Background The cardiovascular-kidney-liver-metabolic (CKLM) framework represents the multi-organ interplay of systemic metabolic disorders that drive the global burden of cardiovascular diseases (CVD). Methods This study is a descriptive epidemiological analysis of the Global Bur...

Beyond Surface Catalysis: Dynamic Cation‐Regulated Interfacial Water Gating for Aqueous Polysulfide Electrochemistry

ABSTRACT Aqueous sulfur electrochemistry holds great promise for high‐energy density storage but is currently constrained by sluggish redox kinetics and severe polarization. Despite extensive efforts in catalyst design to enhance polysulfide adsorption, kinetic improvements have...

CoxFormer enables spatial omics inference with multimodal generative modeling

Gene co-expression maps transcriptome-wide gene-gene relationships, yet high-quality estimates cover less than half the genome. Meanwhile, spatial omics either profiles restricted in situ panels or lacks cellular resolution. Extending co-expression transcriptome-wide could overco...

Evaluation of Flexural Capacity of Prestressed Composite Girders with Corrugated Steel Webs at Elevated Temperatures

Abstract Prestressed composite girders with corrugated steel webs (PCGCSWs), widely adopted in bridge engineering, are particularly vulnerable to fire-induced damage due to the combined effects of mechanical properties degradation in the temperature-sensitive steel web and prestr...

A Ship Yaw-Angle Separation Method Based on Empirical Mode Decomposition and Multi-Dimensional Physical–Statistical Evaluation

The yaw-angle signal output by shipboard attitude sensors (e.g., inertial navigation systems) is a composite of the heading and wave-induced yaw (WIY). The heading reflects large-scale directional changes due to maneuvering or voyage planning, exhibiting slowly varying, trend-lik...

Complex-Network-Guided High-Risk Substation Identification and Targeted Mitigation of Transformer DC Bias in Multi-Infeed UHVDC Receiving-End Grids

In multi-infeed UHVDC receiving-end grids, transformer DC-bias risk is affected not only by the magnitude of grounding-electrode current, but also by the AC-grid topology, substation grounding condition, voltage-level-dependent current limits, and polarity coordination among grou...

Iteratively DesignedPhospholipid-Targeted SupramolecularSonosensitizers for Precision Treatment of Pulmonary Infections

Abstract Fungal infections represent a significant global health threat, exacerbated by the scarcity of new therapeutic options, increasing drug resistance, and host toxicity. Sonodynamic therapy (SDT) offers a promising approach to overcoming antimicrobial resistance by enabling...

Enantioselective Convergent Synthesis of Heterohelicenes via Copper-Catalyzed Propargylic Annulation/Acid-Promoted Aromatization

Abstract Heterohelicenes combine helical chirality with tunable electronic properties, making them attractive for applications in chiral materials and optoelectronics. However, their enantioselective synthesis, particularly for five-membered heterohelicenes, remains a long-standi...

Asymmetric RBBP7 regulates the first cell fate decision of early mammalian embryos

Asymmetric transcription of noncoding RNA LincGET is currently recognized as the earliest event regulating the first cell fate decision in mammalian embryogenesis. However, whether key protein factors modulate this process remains elusive. Here, we identify RBBP7 as the earliest...

SRPK3 exacerbates cardiac ischemia/reperfusion injury by regulating KLF3-mTOR/P70 S6K-mediated autophagy

Myocardial ischemia-reperfusion (I/R) injury remains a leading cause of cardiac dysfunction and mortality worldwide. Serine/arginine-Rich Protein Kinase 3 (SRPK3) is highly expressed in cardiac muscle, yet its specific pathological role in I/R injury has not been fully characteri...

Pauling‐Type Multi‐Oxygen Adsorption of Amorphous MoS x Cocatalysts for Boosting Photocatalytic H 2 O 2 Production

ABSTRACT The loading of cocatalysts and the modulation of their electronic properties play a crucial role in boosting photocatalytic H 2 O 2 production. However, cocatalyst surfaces often feature multi‐oxygen adsorption configurations, and how such adsorption states influence cha...

Occlusion-Robust Cattle Pose Estimation for Precision Livestock Monitoring Using Hierarchical Locality Refinement

Accurate cattle pose estimation is important for precision livestock farming because body landmarks can provide quantitative visual inputs for potential health monitoring, behavior analysis, lameness assessment, and welfare evaluation. This study focuses on keypoint-localization...

A new platform for achieving long-term air-stable long persistent luminescence in amorphous organic system

Abstract Organic long persistent luminescence (OLPL) materials are at the forefront of research, undergoing rapid evolution due to their extensive potential applications. The realization of hour-level OLPL, particularly an air-stable one, remains a significant challenge. Here, we...

OGSAgent: an MCP-based multi-agent collaboration framework for intelligent GIServices

The vision of intelligent GIServices (Geographic Information Services) is to automatically discover, compose and execute distributed GIServices to address global challenges. Recent studies show that LLM (large language model)-based agents can autonomously use external services, w...

Biomolecular condensates as dynamic regulators of musculoskeletal homeostasis, disease, and therapeutic challenges

Abstract Biomolecular condensates are membraneless assemblies that concentrate proteins, nucleic acids, and other biomolecules into dynamic cellular compartments. Liquid-liquid phase separation (LLPS) is one important route by which such condensates form, particularly when multiv...

A Blockchain-Enabled Security Framework for Cloud-Based Sensor Systems with Deep Learning-Driven Attack Classification

Cloud-integrated sensor and Internet of Things (IoT) systems enable scalable data storage, processing, and intelligent monitoring, but their distributed nature exposes network-flow and host-level data to unauthorized access, tampering, and cyberattacks. This study proposes a Weig...

Biocontrol of tomato soilborne diseases by fungivorous nematode Aphelenchoides bicaudatus

<title>Abstract</title> Crop soil-borne diseases caused by pathogens, such as Fusarium spp. and root-knot nematodes, contribute to substantial yield losses worldwide. This study investigated the biocontrol potential of the fungivorous nematode, Aphelenchoides bicaudatus isolate A...

Adolescent environmental enrichment prevents early-life stress-induced schizophrenia-like phenotypes via restoration of CREB-BDNF-TrkB signaling

Early-life stress (ELS) is a major environmental risk factor for schizophrenia, yet effective preventive strategies targeting its neurodevelopmental consequences remain limited. Here, we show that adolescent environmental enrichment (EE) prevents the emergence of schizophrenia-li...

Generative Logic and the Mediatization of Politics: Deepfake Parodies and Political Reinterpretation in China

This study revisits the theory of the mediatization of politics in the era of artificial intelligence (AI), questioning its applicability beyond Western democracies and proposing an extension through the concept of generative logic. Drawing on the analysis of AI-generated parodie...

Patient-specific static and dynamic 3D-printed models for planning endovascular repair of complex aortic disease with physician-modified stent grafts

Abstract Objective To develop a patient-specific static and dynamic 3D-printing workflow for preoperative planning of endovascular repair in complex aortic disease with physician-modified stent grafts, to assess the respective roles of rigid anatomical and dynamic models, and to...