Wenzhou Medical University

pH responsive nanoplatforms for radiosensitization and radioprotection in cancer therapy

Radiotherapy remains a cornerstone of cancer treatment, but its efficacy is limited by tumor hypoxia, adaptive antioxidant defenses, and the resulting radioresistance. Tumor extracellular acidity, commonly reported within an approximate pH range of 6.5–7.1, contributes to invasio...

MIDAS: A multimodal interview-based framework for depression assessment from clinical interviews

Automated depression assessment from clinical interviews is a challenging intelligent healthcare task because depressive states are reflected not only in verbal responses, but also in acoustic and visual-behavioral cues. Existing multimodal methods have improved prediction perfor...

Comparison of seven machine learning models for predicting prolonged PACU length of stay: performance evaluation and identification of key influencing factors

Abstract Background Prolonged stays in the post-anesthesia care unit (PACU) significantly increase healthcare resource utilization and delay postoperative recovery. Current research on PACU prolonged stays is mostly limited to univariate analyses, lacking multidimensional, high-a...

Systemic Coagulation-Inflammation Index Predicts Functional Outcomes After Aneurysmal Subarachnoid Hemorrhage: Mediation by Delayed Cerebral Ischemia

The systemic coagulation-inflammation (SCI) index reflects both coagulopathic and inflammatory dynamics. We investigated its association with delayed cerebral ischemia (DCI) and functional outcome in aneurysmal subarachnoid hemorrhage (aSAH), explored the mediation effect of DCI...

Outcomes of modified pneumatic retinopexy with transscleral subretinal fluid drainage for primary rhegmatogenous retinal detachment

Abstract Background Primary rhegmatogenous retinal detachment (RRD) occurs when a retinal tear or break causes fluid from inside the eye to seep behind the retina, which pushes it away from the wall of the eye. This can cause permanent vision loss if not treated. Which of three c...

Longitudinal alignments and syntheses of multimodal clinical data for personalized medicine with the PULSE framework

Multimodal models capable of imputing diverse data used in single-cell biology studies provide potential foundational opportunities in clinical practice. However, patient data uniquely comprise longitudinal mosaic measurements that reflect underlying physiological dynamics and ex...

Systemic and local oxidative stress biomarkers in periodontitis: an updated systematic review and meta-analysis

To update and extend our previously published 2019 systematic review by evaluating oxidative stress (OS) biomarkers in saliva, gingival crevicular fluid (GCF), and blood in relation to periodontitis. We systematically searched five electronic databases including PubMed, Scopus, E...

Preoperative lung ultrasound score and multifactorial predictors of 1-year mortality in geriatric hip fracture patients with pneumonia: a retrospective cohort study

Abstract Background Preoperative pneumonia severity independently predicts postoperative mortality in elderly hip fracture patients, yet accurate assessment remains challenging. This study evaluated lung ultrasound score (LUS) for predicting 1-year mortality and compared its pred...

Rhizosphere Bacterial Communities of Two Coastal Halophytes Under Salinity–Flooding Stress

Soil salinisation and periodic flooding jointly shape coastal wetland ecosystems, but how coexisting halophytes differ in their rhizosphere bacterial communities under these conditions remains insufficiently understood. Here, we investigated rhizosphere bacterial communities asso...

A large-scale multi-center analysis reveals that HNRNPA2B1 variants increase neuroblastoma risk in Chinese children

Neuroblastoma has significant clinical heterogeneity, more precise genetic biomarkers are needed for early risk stratification. Although m 6 A modification has been reported to affect tumor development, the epidemiological impact of HNRNPA2B1 polymorphisms on neuroblastoma suscep...

USP10 mitigates Ang II–induced atrial remodeling and atrial fibrillation susceptibility by deubiquitinating NDUFS1

Atrial fibrillation (AF) contributes to cardiovascular morbidity and mortality. Ubiquitin-specific peptidase 10 (USP10) plays a crucial role in numerous cellular processes; however, its particular role in AF remains largely unexplored. In the present study, USP10 expression was a...

Identification of a novel small-molecule modulator targeting SNX10 to inhibit osteoclastic bone resorption

Current antiresorptive therapies reduce bone loss by eliminating osteoclasts or inhibiting their formation. However, these approaches could disrupt osteoclast-osteoblast communication and cause serious complications with long-term usage. There is a need for developing new therapi...

Dynamic 5-hydroxymethylcytosine remodeling associated with synaptic gene programs in the striatum of a Parkinson’s disease mouse model

The striatum, a key structure within the basal ganglia, undergoes functional dysregulation following the loss of dopaminergic input, contributing to the motor symptoms of Parkinson’s disease (PD). However, the involvement of DNA hydroxymethylation in striatal dysfunction remains...

The global cardiovascular-kidney-liver-metabolic burden from 1990 to 2023

Background The cardiovascular-kidney-liver-metabolic (CKLM) framework represents the multi-organ interplay of systemic metabolic disorders that drive the global burden of cardiovascular diseases (CVD). Methods This study is a descriptive epidemiological analysis of the Global Bur...

Associations of C-reactive protein-triglyceride-glucose index and cholesterol-high-density lipoprotein-glucose index with heart disease risk in individuals with cardiovascular-kidney-metabolic syndrome stages 0–3: a cohort study from CHARLS

Abstract Background Although the C-reactive protein-triglyceride-glucose index (CTI) and cholesterol-high-density lipoprotein-glucose index (CHG) have both been implicated in adverse cardiovascular outcomes, their comparative predictive performance for incident heart disease amon...

Effects of weighted jump-squat set configuration on acute explosive performance and fatigue responses in resistance-trained men: a randomized crossover study

Weighted jump squats are commonly used to acutely enhance explosive performance, but the optimal organization of repetitions and rest intervals remains unclear. This study compared the effects of traditional, cluster, and rest-redistributed weighted jump-squat configurations on c...

Complete biosynthesis of the clinical agent escin Ia

Abstract Escin Ia is a barrigenol-type triterpenoid specific to Aesculus seeds and is widely utilized in clinical practice for the treatment of cerebral edema, swelling, and venous insufficiency. Here, we fully elucidated its biosynthetic pathway by identifying ten previously unc...

Synergistic anti-obesity therapy: ursolic acid-loaded mesoporous polydopamine nanoparticles (MPDA@UA) in an injectable OHA-CMCS hydrogel with a mild photothermal effect for adipocyte reprogramming

Obesity and its metabolic complications urgently require safe, effective, and minimally invasive interventions. Here, we engineered an injectable, self-healing hydrogel system (OCMU hydrogel) based on oxidized hyaluronic acid (OHA) and carboxymethyl chitosan (CMCS) for the locali...

Stepwise Electrosurgical Bailout During Difficult Left Bundle Branch Area Pacing

Electrosurgical energy may facilitate difficult septal lead advancement during left bundle branch area pacing (LBBAP), but procedural feedback after each application is poorly defined. A 63-year-old woman with complete atrioventricular block had persistent left ventricular septal...

An Intracellular Lysate Sustained-Release Nanohydrogel Promotes Osteogenesis and Angiogenesis

Introduction and aims Nanomaterials hold great promise for applications in bone tissue engineering. Dental pulp stem cell (DPSC) lysate, as a kind of intracellular lysate, has attracted increasing attention as a bioactive, cell-free therapeutic component in bone tissue engineerin...