Wenzhou Medical University

RSPO1–LGR4 axis drives cervical cancer progression via activation of the EGFR/Src/ERK/AKT signaling pathway

Cervical cancer (CCa) is a leading cause of cancer-associated mortality among women globally, posing a substantial health burden, particularly in low- and middle-income countries where HPV vaccination coverage remains limited. Therefore, identifying novel therapeutic targets to i...

Invasive Pneumococcal Disease in Children: A Retrospective Three-Center Study in Zhejiang Province, China (2010–2024)

Invasive pneumococcal diseases (IPD) are among the leading causes of global child mortality. Pneumococcal conjugate vaccines provide direct protection against IPD caused by serotypes included in the vaccine. To investigate the clinical characteristics, serotypes, and antibiotic r...

A DMD-enabled multimode fiber wavefront shaping interface for spatially addressable optogenetic stimulation

Spatially confined and rapidly addressable light delivery is important for optogenetic stimulation when optical access to the target plane is limited. Digital micromirror device (DMD) has shown its potential for rapid optical control and wavefront shaping through scattering media...

Development and Analytical Validation of a Smartphone‐Based Quantitative Lateral Flow Immunoassay for Serum Cystatin‐C

ABSTRACT Background Cystatin‐C is an important renal function biomarker, but conventional quantification requires centralized laboratory analyzers, limiting timely testing in primary care and resource‐limited settings. Methods We developed and validated a quantitative smartphone‐...

Repurposing ritonavir to induce proteasomal degradation of IE1 for inhibition of human cytomegalovirus replication

Human cytomegalovirus (HCMV) is a major pathogen affecting immunocompromised individuals. Current antiviral drugs target the mid-to-late stages of viral replication but are limited by toxicity and drug resistance. The IE1 protein serves as a key early regulator of HCMV replicatio...

Chlorogenic Acid Derivative B11 Inhibits Glioma Proliferation by Targeting MST4 to Regulate Oxidative Stress

ABSTRACT This study focuses on the mechanism of action of chlorogenic acid derivative B11 on glioma. Although chlorogenic acid exhibits certain anti‐tumor activity, it has limitations such as low bioavailability, broad action targets, and insufficient specificity, which restrict...

Serum basic amino acids, prolactin, and insomnia severity in perimenopausal individuals: a cross-sectional sub-study

Insomnia symptoms are common during the menopausal transition, but estrogen-centered explanations do not fully account for inter-individual variation. We examined whether serum prolactin was associated with insomnia severity and whether circulating basic amino acids modified this...

Textural features of retina and choroid obtained via machine learning based on OCT image identify early macular degeneration in high myopia

To study a set of textural features based on optical coherence tomography (OCT) images using texture analysis via machine learning to demonstrate their potential for early identification of macular degeneration in high myopia (HM). Two hundred and eighty-eight eyes of 166 partici...

The natural course of pediatric epididymal cysts during puberty: resolution trends and predictive value of baseline size

Epididymal cysts represent a frequent benign scrotal finding in boys, yet their natural history throughout the pubertal transition remains insufficiently understood. Current clinical guidance is largely derived from adult data, and objective predictors of spontaneous regression d...

Dissecting the associations of cardiovascular health, biological aging, and blood DNA methylation signatures with chronic respiratory disease risk

The interplay between cardiovascular health (CVH), biological aging, and underlying epigenetic mechanisms in relation to chronic respiratory diseases (CRDs) remains unclear. We conducted a large-scale prospective cohort study including 181,955 participants from the UK Biobank. Ca...

Autism spectrum disorder burden in China and worldwide, 1990–2021

Autism spectrum disorder (ASD) imposes a substantial public health burden. This study quantified and compared the ASD burden in China and globally from 1990 to 2021 to inform policy and planning. We analyzed Global Burden of Disease 2021 estimates of age-standardized prevalence r...

Molecular Insights into the Bacterial Membrane Interactions of Proline-Stabilized Graphene: Effects of Proline Oligomerization

Abstract Multidrug-resistant bacterial infections pose a major global health challenge. Graphene nanosheets exhibit promising antibacterial activity through membrane disruption, but their practical application is limited by poor aqueous stability and biocompatibility. A recent st...

FIMA-Net: a network with focused feature interaction fusion module with lightweight scale-aware attention for skin lesion image segmentation

Abstract Accurate segmentation of lesion regions in skin images plays a critical role in computer-aided diagnosis systems for skin lesions. However, due to the inherently complex structure of skin lesion images and the low contrast between some lesion regions and the surrounding...

Construction of a drug screening model for Mycobacterium abscessus infections

Abstract The management of Mycobacterium abscessus infections is critically hindered by its inherent multidrug resistance and the lack of effective therapies, necessitating advanced preclinical models for drug discovery. Here, we developed a sequential screening platform, progres...

Effectiveness and Safety of Fixed‐Dose Combination Metformin and Empagliflozin in Type 2 Diabetes: A Prospective, Multicenter, Real‐World Study From China

BACKGROUND: This study assessed the real-world effectiveness and safety of a fixed-dose combination (FDC) of metformin and empagliflozin in Chinese patients with type 2 diabetes mellitus (T2DM). METHODS: This prospective, multicenter, real-world study enrolled consecutive patient...

Persistent Zn 2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn 2+ ‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

ABSTRACT Intervertebral disc degeneration (IVDD) is an age‐related disease accompanied by disrupted mitochondrial homeostasis and defective autophagy. Cellular senescence induces ion imbalance, which leads to mitochondrial damage and suppressed autophagic flux; nevertheless, the...

Asymmetric Structure‐Driven Functional Synergy: A Multistimuli‐Activated Janus Nanomotor for Self‐Amplifying NO Cascade Therapy

ABSTRACT Nitric oxide (NO)‐based cancer therapy is fundamentally limited by poor intratumoral penetration of exogenous donors and their inability to sustain localized relevant flux. Here, a multistimuli‐activated Janus nanomotor was developed to interconnect nonenzymatic and enzy...

More-efficient water splitting utilizing heated-cooled active pure water with reduced hydrogen bonds

Within the realm of renewable energy technologies—particularly those centered on hydrogen evolution reactions (HERs) and oxygen evolution reactions (OERs)—noble metals have long been regarded as the archetypal catalytic materials. In recent years, however, research efforts have p...

Positional and morphological characteristics of palatally impacted maxillary central incisors

Palatally impacted maxillary central incisors are commonly caused by obstructive phenomena and trauma, predisposing them to root dilaceration and subsequent aesthetic and functional complications. The three-dimensional intraosseous position of maxillary central incisors dictates...

Association between life’s essential 8 and epilepsy

Epilepsy, a prevalent chronic neurological disorder, has significant neurobiological, cognitive, psychological, and social implications. The American Heart Association (AHA) introduced Life’s Essential 8 as a key metric for assessing cardiovascular health. This study aims to inve...