Wenzhou Medical University

Development and validation of a machine learning model integrating clinical and structural brain morphometric features for predicting postherpetic neuralgia: a multicenter cohort study with retrospective development and prospective external validation in China

Postherpetic neuralgia (PHN) is a common and difficult-to-treat complication of herpes zoster (HZ). Early identification of patients at high risk may facilitate risk stratification and individualized intervention. This study aimed to integrate clinical variables with three-dimens...

pH-responsive resveratrol delivery using chitosan-based nanoparticles embedded in GelMA: in vitro evaluation of acute brain injury-relevant cellular responses

Secondary injury after acute brain injury (ABI) involves interconnected oxidative, inflammatory, and apoptosis-associated cellular responses. Resveratrol (RSV) has antioxidant and anti-inflammatory activities, but its limited aqueous stability and rapid clearance restrict sustain...

Associations between patient safety culture, occupational exposure behaviours and patient safety behaviours among operating theatre nurses: a multicentre cross-sectional study

Patient safety in operating theatres is influenced by organisational safety culture and nurses’ safety-related behaviours. Occupational exposure remains a frequent hazard in perioperative settings; however, its relationship with patient safety culture (PSC) and patient safety beh...

XPR1 Promotes the Malignant Phenotypes of Thyroid Carcinoma Cells Partly Through NF-κB-Related Signaling

Background: Xenotropic and polytropic retrovirus receptor 1 (XPR1) is highly expressed in human thyroid carcinoma (TC), yet its functional role remains unclear. In this study, we sought to determine whether XPR1 participates in the progression of thyroid carcinoma and to further...

Copper(II) Complexes Based on Anthraquinone‐1,8‐Disulfonate and Application as High‐Performance pH‐Responsive Fluorescent Switch

Through ligand engineering, three Cu(II) complexes with distinct dimensionalities were successfully constructed. Among them, a dimeric Cu(II) complex ( 1 ) featuring rich intra‐ and intermolecular hydrogen bonding motifs was identified as an excellent pH‐sensitive “on–off” fluore...

Laparoscopic one-stage operation for completely perforated choledochal cyst: two cases report and review of the literature

Choledochal cyst (CDC) perforation is a rare but serious complication, and the optimal surgical strategy remains controversial. To our knowledge, no case of laparoscopic one-stage surgery for a completely perforated CDC with a perforation time exceeding 24 h has been reported. We...

Comment on ‘Effectiveness, safety and tolerability of ozenoxacin 2% lotion vs clindamycin 1% lotion in mild to moderate truncal acne’: considerations regarding sample size and treatment-related withdrawal

This letter discusses two methodological considerations in a randomized trial comparing ozenoxacin 2% lotion with clindamycin 1% lotion for mild-to-moderate truncal acne. We highlight uncertainty regarding the sample-size calculation and the handling of treatment-related withdraw...

An electronic health record-derived glycemic variability-enhanced triglyceride-glucose index for early mortality risk stratification in critically ill patients with acute myocardial infarction: a derivation and external validation study

Electronic health records (EHRs) contain repeated glucose measurements routinely collected during critical care, yet these data are rarely incorporated into early risk-stratification tools for acute myocardial infarction (AMI). The conventional triglyceride-glucose (TyG) index re...

Investigating the divergence of β-lactamase PDC variants conferring various antibiotic resistance profiles in Pseudomonas aeruginosa, coupled with the molecular profiling of PDC-266

Pseudomonas aeruginosa is a critical pathogen in hospital-acquired infections, with resistance primarily mediated by chromosomally encoded blaPDC alleles. While wild-type PDCs typically hydrolyze penicillins and cephalosporins, specific amino acid substitutions can broaden their...

Coronary plaque phenotypes, inflammation and cardiovascular prognosis in metabolic dysfunction-associated steatotic liver disease

Metabolic dysfunction-associated steatotic liver disease (MASLD) correlates with cardiovascular events. We sought to assess the association of coronary computed tomographic angiography (CCTA)-detected high-risk plaque characteristics (HRPC) and coronary inflammation with MASLD an...

The Onychomys pangenome reveals the unique molecular adaptations that confer toxin resistance

Abstract Background Predatory grasshopper mice ( Onychomys sp.) have co-evolved resistance to painful and lethal neurotoxins produced by their scorpion prey. Previous studies have reported that structural and functional modifications of the sodium channel Nav1.8 block the effect...

Non-Canonical Peptide Self-Assembly for Mitochondria-Specific Cargo Delivery

Abstract Targeting mitochondria is a promising strategy for precision tumor therapy, yet ligand-free mitochondrial drug delivery remains challenging. Here, we report a minimalist, intrinsically mitochondria-targeting noncanonical tetrapeptide, X-GNNpY, comprising one glycine, two...

Multi-Scale MRI, Radiology Reports, and Blood Biomarker–Guided Multimodal Deep Learning for Predicting Postoperative Recurrence in Cervical Cancer: A Multicenter Study

Objectives: Cervical cancer (CC) remains a leading cause of cancer-related morbidity and mortality among women worldwide, with postoperative recurrence posing a major challenge to long-term survival. Multimodal data integration, including imaging, textual, and clinical informatio...

Pulmonary Tropheryma whipplei infection in a patient with systemic lupus erythematosus: diagnosis supported by BALF tNGS with subsequent doxycycline-based treatment: a case report

Whipple’s disease is a rare systemic infection caused by Tropheryma whipplei ( T. whipplei ). Pulmonary involvement is uncommon and may mimic sarcoidosis, tuberculosis, or malignancy, delaying diagnosis. Pulmonary presentations may be atypical and nonspecific. We report the case...

Development and validation of a nomogram for predicting disease outcomes in elderly females with lung cancer metastatic to the bone

The incidence of lung cancer in elderly women is gradually increasing and the prognosis is even more worrying. Notably, approximately one-third of these patients develop bone metastases. The main objective of this study is to develop and validate a tool to achieve accurate progno...

Interpretable multimodal fusion of 18F-PSMA-1007 PET/CT and mpMRI for preoperative ISUP grade prediction in primary prostate cancer

Accurate preoperative International Society of Urological Pathology (ISUP) grading of prostate cancer (PCa) is critical for clinical decision-making. While multi-parametric MRI (mpMRI) is routine, it struggles with occult high-risk lesions due to limited metabolic insights. PET/C...

Xanthatin directly targets ZDHHC7 to inhibit NLRP3 palmitoylation and inflammasome activation, alleviating sepsis and acute lung injury

Aberrant activation of the NLRP3 inflammasome drives the pathogenesis of diverse inflammatory diseases, including acute respiratory distress syndrome (ARDS) and sepsis. Among the post-translational modifications regulating NLRP3, S-palmitoylation contributes to NLRP3 localization...

Development and validation of MRI-based radiomics models for predicting recurrence in patients with spine and pelvis chordomas

Spine and pelvis chordoma (SPC) is a rare and aggressive mesenchymal tumor with poor long-term recurrence-free survival rates. Accurate preoperative prediction of recurrence remains a significant clinical challenge, and reliable prognostic methods are lacking. To develop and vali...

Analysis of Intelligent Privacy Protection Mechanisms for Smart Healthcare in the Context of the Internet of Things

In Internet of Things-based smart healthcare, while medical data sharing and model training are driving industry development, sensitive patient information is easily stolen and misused, and traditional data processing models struggle to balance security and usability. This resear...

Prediction of low oocyte retrieval in young women undergoing IVF/ICSI: a multicenter external validation study

Abstract Objective To externally validate a previously developed pretreatment prediction nomogram for identifying young women at risk of low oocyte retrieval (LOR). Methods This multicenter retrospective study included 14,702 women aged ≤ 35 years undergoing their first in vitro...