Wenzhou Medical University

Regional Dependence of Corvis ST Biomechanical Parameters on Corneal Material Properties: A Finite Element Study

Background: Corvis ST (CVS) provides dynamic corneal response parameters for biomechanical assessment, but conventional metrics may not uniquely reflect region-specific alterations in corneal material properties. This study investigated how regional changes in corneal material pr...

Impact of carotenoids on body composition and adipokine hormones: a systematic review and meta-analysis of randomized controlled trials

Carotenoids, a class of antioxidant phytochemicals, have been proposed to influence adiposity and metabolic regulation through modulation of oxidative stress, inflammation, and adipokine secretion. However, clinical evidence remains inconsistent. This systematic review and meta-a...

Osimertinib With or Without Chemotherapy in Advanced Non–Small Cell Lung Cancer With EGFR and Concurrent TP53 Mutations

Importance: Combination therapy has emerged as a promising therapeutic approach for patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). However, its clinical benefit-risk profile remains a focus of ongoing debate. Identifying patients...

Differentiating Chlamydia psittaci pneumonia from community-acquired pneumonia using clinical features and computed tomography findings

Chlamydia psittaci pneumonia (CPP) is a rare disease that is difficult to diagnose. Its clinical manifestations and chest imaging findings often overlap with those of other types of community-acquired pneumonia (CAP), and nonspecific treatment is likely to lead to rapid disease p...

Noninvasive Detection of MASH and Fibrotic Burden Using Ultrasound‐Derived LIID and LSM in MASLD: A Multicenter Study

ABSTRACT Background and Aims Metabolic dysfunction‐associated steatohepatitis (MASH), the progressive form of metabolic dysfunction‐associated steatotic liver disease (MASLD), is associated with adverse hepatic and cardiometabolic outcomes. The study aimed to validate a novel qua...

Oral anticoagulation therapy in nonagenarian patients with atrial fibrillation: usage patterns, predictors, and in-hospital outcomes from a single-center retrospective study

Abstract Background Atrial fibrillation (AF) is highly prevalent in nonagenarians (≥ 90 years). However, this group is often excluded from clinical trials, leaving limited real-world evidence on oral anticoagulant (OAC) use, safety, and efficacy. This study sought to investigate...

Agentic echocardiography report structuring for cardiovascular prediction and disease association discovery

Noisy echocardiography reports limit data-driven cardiovascular research because measurements that matter for downstream modelling remain in scanned images, multilingual narratives or semi-structured tables. This study presents an end-to-end agentic pipeline that takes such repor...

Resource Orchestration for Sustainable Innovation Capacity Development Among University Students: A Configurational Analysis

The rapid development of artificial intelligence has intensified the need for higher education institutions to cultivate students’ capacity to engage with complex and changing innovation problems. Existing research has largely examined the net effects of individual educational re...

Latent profiles and predictors of fear of childbirth in late pregnancy: a parity-specific analysis

Fear of childbirth (FoC) is a common psychological concern among women in late pregnancy. Variation in reported prevalence and associated factors across studies reflects methodological heterogeneity and highlights the need for person-centred approaches to identify clinically mean...

Cosmetic parameters associated with SRS-22r improvement postoperatively in patients with adolescent idiopathic scoliosis: a 2-year follow-up

Adolescent idiopathic scoliosis (AIS) significantly impacts physical appearance and quality of life. This exploratory study aims to investigate potential association between cosmetic parameters and minimal clinical improvement in SRS-22r scores at a 2-year follow-up in AIS patien...

Orbital apex syndrome caused by imaging-occult sphenoid sinus fungal infection and the necessity of early surgical exploration: a retrospective case series

To characterize a highly occult subtype of sphenoid invasive fungal rhinosinusitis (IFRS) presenting as acute orbital apex syndrome (OAS) without classic invasive imaging signs, and to evaluate the efficacy of early surgical intervention. This retrospective case series evaluated...

Stromal Cells Recruitment by Sono‐Piezoelectric/Pyroelectric Peptide Hydrogels Promotes Bone Regeneration After Postsurgical Osteosarcoma Recession: A Real‐World‐Matched Study

ABSTRACT Currently, the elimination of postsurgical osteosarcoma (OS) and defect repair are still separately explored, which is unlike real‐world clinical scenarios. Inadequate bone marrow stromal cells (BMSCs) compromise their repair and antitumor efficiencies. Here, PFSSTKT (PF...

A Metabo‐Reprogramming Niche Remodeling System Halts Osteoarthritis by Restoring the FGF21‐Arginine Axis

Osteoarthritis (OA), a global leading cause of chronic pain and disability, lacks disease-modifying osteoarthritis drugs (DMOADs) targeting its core pathogenesis. scRNA-seq of human OA cartilage showed marked depletion of a high-arginine-metabolism chondrocyte subpopulation drivi...

3D epigenomic landscape of the human retinal pigment epithelium

The retinal pigment epithelium (RPE) is crucial for visual function, and its dysfunction contributes to retinal diseases such as age-related macular degeneration. Despite the translational potential of iPSC-derived RPE (iPSC-RPE) in cell replacement therapy, the functional visual...

Self‐Compassion Among Undergraduate Nursing Students: A Latent Profile Analysis

ABSTRACT Self‐compassion is a core professional value in nursing and is positively associated with nursing students' psychological well‐being, academic performance, and caring behaviors. However, heterogeneity and influencing factors in self‐compassion among nursing undergraduate...

Senescence-related immunosuppressive gene MFAP2 orchestrates stromal-immune crosstalk and immunotherapy resistance in gastric cancer

Abstract Background Gastric cancer (GC) is a leading cause of cancer-related mortality worldwide, with poor prognosis and immune checkpoint inhibitor (ICI) resistance mediated by immune escape. Senescence-related immunosuppressive genes (SRIGs) regulate the tumor microenvironment...

Smart nanoparticle-assisted nucleic acid delivery for targeted therapy and tissue repair

Tissue repair necessitates precise temporal regulation of cell proliferation, differentiation, and angiogenesis. Nucleic acid drugs exhibit significant therapeutic potential, but they encounter challenges such as low delivery efficiency, nuclease degradation, poor membrane penetr...

Peptide-targeted cubosome and hexosome nanoassemblies mitigate mitochondrial dysfunction in a MitoPark model

Mitochondrial dysfunction is a primary pathogenic mechanism underlying dopaminergic neuron loss in the nigrostriatal pathway in Parkinson's disease (PD). To investigate mitochondrion-targeted therapeutic strategies, we utilized the MitoPark mouse model, in which mitochondrial tra...

Derivation of a novel risk assessment model of venous thromboembolism in hospitalized patients

Background Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE), significantly contributes to morbidity and mortality among hospitalized patients. Despite the existence of various VTE risk assessment models (RAMs), their performance...

Predictors of falls efficacy among community-dwelling older adults with ischemic stroke in Wenzhou, China: a cross-sectional study

Purpose This study aimed to examine the level of falls efficacy and identify its predictors among community-dwelling older adults with ischemic stroke in Wenzhou, China. Design/methodology/approach A cross-sectional descriptive study was conducted with 335 participants aged 60–75...