Wenzhou Medical University

Acupoint hot compress for labor-pain management: a randomized, parallel-group, controlled trial

Background Non-pharmacological pain management approaches, including acupoint hot compress, may provide valuable support for women dealing with pain during the latent stage of labor, but the evidence supporting this effect is limited. We investigated whether acupoint hot compress...

Prolonged growth hormone pretreatment is associated with improved embryo quality in women with poor quality embryos in previous IVF cycles

Abstract Background Approximately 10–15% of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles have most embryos of poor quality, often characterized by extensive anuclear cytoplasmic fragments. These cycles are usually associated with poor reproducti...

An impaired excitatory-inhibitory balance in the right inferior temporal gyrus of patients with Alzheimer's disease correlated with executive function

Preliminary research indicates that an imbalance between excitation and inhibition may be an early pathological feature of Alzheimer's disease. However, the relevant brain networks, neurotransmitters and genetic mechanisms are still unclear. This study enrolled 27 patients with A...

Longitudinal Associations Among Maternal Health Literacy, Psychological Empowerment and Health‐Promoting Behaviours in Rural Pregnant Women: A Cross‐Lagged Panel Study

AIMS: To examine longitudinal associations among maternal health literacy, psychological empowerment and health-promoting behaviours across pregnancy among rural pregnant women. DESIGN: Prospective cohort study. METHODS: Between 1 May 2023 and 15 January 2024, 694 rural pregnant...

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...

Coexistence of high-risk HPV infection and FANCC heterozygous variation in early young esophageal squamous cell carcinoma: a case report and literature review

<title>Abstract</title> <bold>Background:</bold> Esophageal cancer poses a major health challenge in China, with current screening targeting individuals over 40. However, rising incidence in younger populations, often with atypical symptoms, leads to delayed diagnosis. Investigat...

Joint high level of low-density lipoprotein and high-sensitivity C-reactive protein are associated with early neurological deterioration after thrombolysis in patients with mild stroke

Low-density lipoprotein (LDL) and high-sensitivity C-reactive protein (hs-CRP) play important roles in cardiovascular and cerebrovascular diseases through pathways such as inflammation and oxidative stress. We aimed to explore whether LDL and hs-CRP were associated with early neu...

Prophylactic Low-Dose Dexamethasone for Postoperative Pulmonary Complications in Type B Aortic Dissection: A Retrospective Cohort Study

AIM: To evaluate the impact of prophylactic low-dose glucocorticoids on the incidence of postoperative pulmonary complications (PPCs) and perioperative recovery parameters in patients undergoing surgery for type B aortic dissection.METHODS: This retrospective cohort study analyze...

A unified mechano-ionic skin for resolving native electromechanical coupling

The beat-to-beat electromechanical coupling between cardiac excitation and arterial pulse propagation encodes vital cardiovascular insights, but resolving this coherence in wearables is hindered by the spatial decoupling of sensors and attenuated epidermal signals. Here, we repor...

Unraveling theR-Enantiomer Preference in Mirror-ImageCyclodextrin: An Integrated Multiscale Computational Study

Abstract L-β-Cyclodextrin (L-CD), the mirror-image isomer of native β-cyclodextrin, provides a conceptually novel chiral microenvironment for pharmaceutical enantioseparation; however, its full separation potential and recognition mechanism remain largely unexplored, hindering it...

Ultrasmall PolymericMicelles Enable Noninvasive TransdermalRosiglitazone Delivery via Lipid Fluidization and Transcytosis

Abstract Noninvasive transdermal drug delivery (TDD) offers sustained therapeutic release but is hindered by the stratum corneum (SC) barrier. Herein, we report ultrasmall polymeric micelles (PMs) embedded in poly(vinyl alcohol) hydrogels for the passive TDD of rosiglitazone (RGT...

Direct Synthesisof Pyrazolones via N–B BondFunctionalization: Sequential Carbonyl Insertion Using In Situ Generated N , N ′-Diborylated Hydrazines

Abstract We report a metal-free protocol for the synthesis of 1,2-diaryl pyrazol-3-ones through the strategic exploitation of N,N′-diborylated hydrazine reactivity. The transformation employs a 4,4′-bipyridyl-catalyzed system that enables in situ generation of N,N′-diborylated hy...

Carbohydrate food structure before sugar dose in metabolic ageing after hypertension or diabetes

Hypertension and diabetes make large populations candidates for dietary counseling, yet carbohydrate advice is often narrowed to reducing sugar intake. This study asked whether carbohydrate food structure should be assessed before sugar dose using biological ageing and renal risk...

Chemotherapy remains effective in ALK-TKI therapy: a retrospective analysis in ALK-positive advanced NSCLC

Tyrosine kinase inhibitors (TKIs) are the standard therapy for advanced non-small cell lung cancer (NSCLC) harboring anaplastic lymphoma kinase (ALK) fusions. However, acquired resistance remains a major challenge, necessitating strategies to prolong therapeutic efficacy. This st...

Surgical case order is associated with postoperative infection risk in total knee arthroplasty

Total knee arthroplasty is regarded as the most effective treatment for severe knee joint problems. Surgery case order influences operative outcomes according to previous studies. This study aims to evaluate the effect of surgical case order on operative outcomes for TKA. A retro...

Hepatocyte-intrinsic ER stress and NRF2 initiate primary sclerosing cholangitis, providing therapeutic insights

primary sclerosing cholangitis (PSC) is a severe liver disease that can progress to cholangiocarcinoma. Therapeutic development has been hindered by the rarity of PSC and by its poorly understood origin, which reflects incompletely defined genetic and environmental risk factors....

Exercise-Induced Regulation of Bone Remodeling via Mitophagy: A Review of Current Evidence

Bone remodeling imbalance represents the fundamental pathological basis of osteoporosis. Exercise is broadly regarded as a valuable non-pharmacological strategy for preventing and managing osteoporosis; however, the precise molecular mechanisms through which exercise modulates bo...

Epidemiological Characteristics of Pediatric Drug Poisoning in Wenzhou, China in 2017–2024

To examine the evolving epidemiological characteristics of pediatric drug poisoning in Wenzhou, China from 2017 to 2024, focusing on temporal trends, age/sex-specific risks, and changes in poisoning intent and toxin types, and to generate evidence-based guidance for targeted prev...

Application of 80 kVp combined with deep learning reconstruction algorithm in overweight patients coronary CT angiography: reduced radiation dose and contrast agent dose

<title>Abstract</title> Background: Coronary CT angiography (CCTA) has become a key imaging technique for clinical screening of coronary artery disease (CAD). Overweight patients have a higher prevalence of CAD, however, they face increased risks of radiation exposure and contras...

Macrophage RIPK3 facilitates TRAF6 K63-linked ubiquitination and exacerbates acute pancreatitis

Abstract Acute pancreatitis (AP) is characterized by acinar cell injury and death triggered by multiple etiologies, culminating in local and systemic inflammatory responses. Current therapeutic options for AP, particularly severe AP, remain limited. While RIPK3-mediated necroptos...