Wenzhou Medical University

Dose-response relationship of prophylactic norepinephrine infusion for prevention of spinal anesthesia-induced hypotension during caesarean delivery: A comparative study of normal weight and obese parturients.

Obese parturients are at increased risk of spinal anesthesia-induced hypotension during cesarean delivery, but optimal prophylactic norepinephrine dosing remains unclear. In this randomized, double-blind, dose-response study, 200 parturients undergoing elective cesarean delivery...

Sex-dimorphic phenotypic divergence in metabolically driven thyroid nodules: the interplay of systemic inflammation and adiposity

Metabolic dysfunction has been increasingly implicated in thyroid nodule development; however, the sex-specific interplay between systemic glucolipotoxicity, adiposity, inflammation, and thyroid nodule risk remains poorly understood. This study aimed to evaluate the association b...

The bile acid receptor TGR5 promotes functional recovery after spinal cord injury by rescuing mitochondrial dysfunction and suppressing AIM2‐mediated pyroptosis

Background and Purpose Previous studies have highlighted the significance of the bile acid receptor TGR5 (also known as Takeda G protein‐coupled receptor 5) in regulating inflammation and mitochondrial homeostasis in various diseases, whereas the specific involvement of TGR5 in s...

Application of a machine learning model integrating T cell subsets and clinical markers in 28-Day mortality prediction of sepsis patients

To develop a machine learning-based prediction model that integrating T cell subset data with clinical features to predict the 28-day mortality risk in sepsis patients. A retrospective cohort study was conducted using the MIMIC-IV database. Collected data included demographics, T...