Wenzhou Medical University

Circumferential pulmonary vein isolation (CPVI) with adjunctive linear ablation vs. CPVI alone for long-standing persistent atrial fibrillation (SINUS): study protocol for a prospective, multi-center, randomized controlled trial

Previous studies have shown that circumferential pulmonary vein isolation (CPVI) alone has a relatively lower success rate for long-standing persistent atrial fibrillation (LSPAF). This study aims to compare the efficacy and safety between CPVI combined with modified linear ablat...

MRC1⁺ macrophages and endothelial PTPRM signalling characterize a microvascular invasion–associated tumor ecosystem in hepatocellular carcinoma

The intercellular interactions and molecular features underlying microvascular invasion (MVI) in hepatocellular carcinoma (HCC) remain incompletely understood. We aimed to characterize the MVI-associated multicellular ecosystem at single-cell resolution and to derive prognostic a...

Colposcopic Imaging Carries Most of the Signal: Externally Validated Tri-Modal Integration of Imaging, Vaginal Microbiome, and Coagulation-Immune Data in HPV-Associated Co-Infection

Background/Objectives: To determine whether a coagulation-immune index, vaginal microbiome composition, and colposcopic imaging carry non-redundant information about HPV-associated lower genital tract co-infection when integrated within a single learned model. Methods: This retro...

Prediction of low oocyte retrieval in young women undergoing IVF/ICSI: a multicenter external validation study

Abstract Objective To externally validate a previously developed pretreatment prediction nomogram for identifying young women at risk of low oocyte retrieval (LOR). Methods This multicenter retrospective study included 14,702 women aged ≤ 35 years undergoing their first in vitro...

Proactive Health Behavior During Pregnancy

Proactive health behavior may enhance maternal well-being during pregnancy, yet the concept remains insufficiently defined in pregnancy-related care and nursing practice. This study used Rodgers’ evolutionary method of concept analysis to clarify the concept and its relevance for...

Chaetocin Induces Ferroptosis in Cisplatin‐Resistant Ovarian Cancer Cells Through Neddylation‐Mediated TFRC Upregulation

Ovarian cancer (OV) is a highly lethal gynecological tumor, often developing platinum chemotherapy resistance and treatment failure. With their diverse and complex structures, natural products offer potential solutions to drug resistance. This study systematically examines chaeto...

Mitophagy induction promotes the maturation of hiPS-derived cardiomyocytes

Mitophagy dysfunction is an important contributor to the occurrence of cardiovascular diseases. Parkin-mediated mitophagy directs perinatal cardiomyocyte metabolism maturation, but its role during the earlier stage of cardiomyocyte differentiation is not fully elucidated. Human-i...

Integrated Assessment of Sarcopenia in Patients with Gastric Cancer Using Deep Learning and Radiomics

ABSTRACT Background Sarcopenia is a common condition in patients with gastric cancer that is associated with poor survival and adverse clinical outcomes. Conventional diagnostic approaches are time‐consuming, limiting large‐scale clinical implementation. This study aimed to devel...

Determination of Hecogenin in Mouse Blood by UPLC–MS/MS and Applied to a Pharmacokinetic Study

ABSTRACT Hecogenin, a steroidal sapogenin from agave plants, exhibits anti‐inflammatory, anti‐tumor, gastroprotective, and diuretic activities. A sensitive ultraperformance liquid chromatography–tandem mass spectrometry (UPLC‐MS/MS) method was developed and validated for quantify...

Study of tumor control probability by stereotactic body radiotherapy with first-generation EGFR-TKIs

Our previous study suggested that patients with advanced epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma treated with first-generation EGFR tyrosine kinase inhibitors (EGFR-TKIs) followed by standard-dose stereotactic body radiotherapy (SBRT) had a larger area...

Clinical and imaging characteristics of cervical ossification of the posterior longitudinal ligament and factors influencing its severity: a retrospective cross-sectional study

Abstract Background Although the prevalence of cervical ossification of the posterior longitudinal ligament (OPLL) and its risk factors for onset and postoperative progression have been well documented, a comprehensive profile of patients with this condition remains lacking, and...

Creatine formulations and repeated sprint training: effects on physical and physiological adaptations in soccer players during the short-term preparation phase

BACKGROUND: This research examined the impact of various creatine (Cr) supplementation formulations during a 4-week preparatory phase on the efficacy of repeated sprint training (RST) and on improvements in physical and physiological performance in male soccer athletes. METHODS:...

Deep learning CT signature for predicting early liver metastases in pancreatic ductal adenocarcinoma

Accurately predicting the risk of early liver metastases (ELM) and identifying patients who are most likely to benefit from neoadjuvant therapy (NAT) are critical for pancreatic ductal adenocarcinoma (PDAC). Here, we develop a Mamba-based predictive model that integrates imaging...

Prospective cohort study of hematoma incidence after ultrasound-guided vacuum-assisted breast excision

Ultrasound-guided vacuum-assisted excision (US-VAE) is increasingly preferred for benign and B3 breast lesions, yet post-procedural hematoma remains the commonest early complication. To prospectively quantify the 7-day incidence of clinically relevant hematoma after US-VAE, descr...

Association between contrast sensitivity and myopia control efficacy

This study compared central visual quality in myopic children wearing spectacles with highly aspherical lenslets (HAL) versus traditional single-vision spectacle lenses (SV) and examined the association between contrast sensitivity and myopia control efficacy. Myopic children age...

Temporoparietal structural-functional coupling abnormalities in drug-naïve youths with major depressive disorder and suicidal ideation

Major depressive disorder (MDD) in youth is associated with higher suicide risk. Although white matter and functional connectivity abnormalities have been reported in MDD patients with suicidal ideation (SI), how brain structure and function interact abnormally remains unclear. W...

Plasma FGF23 and cardiovascular mortality in relation to kidney function among adults with established cardiovascular disease

Fibroblast growth factor-23 (FGF23) has been linked to adverse cardiovascular phenotypes, yet its prognostic relevance among individuals with prevalent cardiovascular disease and the potential modifying role of kidney function remain unclear. We analyzed 9,119 UK Biobank particip...

Occupational creativity and liability to psychiatric disorders: a bidirectional Mendelian randomization study

The long-standing “mad genius” hypothesis proposes a link between creativity and psychiatric illness, but existing genetic evidence has largely relied on genetic correlations and polygenic associations rather than approaches designed to evaluate directional effects. We conducted...

Serum ferritin and ADHD in children: a case-control study accounting for inflammation

To evaluate the association between serum ferritin (SF) and attention-deficit/hyperactivity disorder (ADHD) in children while accounting for C-reactive protein (CRP). This retrospective case-control study included 156 children with DSM-5 ADHD and 164 healthy controls aged 6–12 ye...

Heat stress enhances gut microbial arginine catabolism to amplify MyD88-dependent inflammatory responses

As global temperatures continue to rise, heat stress (HS) has emerged as a major health threat of growing concern. HS triggers systemic inflammation and multi-organ damage, but so far its molecular mechanisms remain unclear. In this study, we explored the potential mechanism by w...