Wenzhou Medical University

The global cardiovascular-kidney-liver-metabolic burden from 1990 to 2023

Background The cardiovascular-kidney-liver-metabolic (CKLM) framework represents the multi-organ interplay of systemic metabolic disorders that drive the global burden of cardiovascular diseases (CVD). Methods This study is a descriptive epidemiological analysis of the Global Bur...

Associations of C-reactive protein-triglyceride-glucose index and cholesterol-high-density lipoprotein-glucose index with heart disease risk in individuals with cardiovascular-kidney-metabolic syndrome stages 0–3: a cohort study from CHARLS

Abstract Background Although the C-reactive protein-triglyceride-glucose index (CTI) and cholesterol-high-density lipoprotein-glucose index (CHG) have both been implicated in adverse cardiovascular outcomes, their comparative predictive performance for incident heart disease amon...

Complete biosynthesis of the clinical agent escin Ia

Abstract Escin Ia is a barrigenol-type triterpenoid specific to Aesculus seeds and is widely utilized in clinical practice for the treatment of cerebral edema, swelling, and venous insufficiency. Here, we fully elucidated its biosynthetic pathway by identifying ten previously unc...

Synergistic anti-obesity therapy: ursolic acid-loaded mesoporous polydopamine nanoparticles (MPDA@UA) in an injectable OHA-CMCS hydrogel with a mild photothermal effect for adipocyte reprogramming

Obesity and its metabolic complications urgently require safe, effective, and minimally invasive interventions. Here, we engineered an injectable, self-healing hydrogel system (OCMU hydrogel) based on oxidized hyaluronic acid (OHA) and carboxymethyl chitosan (CMCS) for the locali...

Effects of weighted jump-squat set configuration on acute explosive performance and fatigue responses in resistance-trained men: a randomized crossover study

Weighted jump squats are commonly used to acutely enhance explosive performance, but the optimal organization of repetitions and rest intervals remains unclear. This study compared the effects of traditional, cluster, and rest-redistributed weighted jump-squat configurations on c...

Stepwise Electrosurgical Bailout During Difficult Left Bundle Branch Area Pacing

Electrosurgical energy may facilitate difficult septal lead advancement during left bundle branch area pacing (LBBAP), but procedural feedback after each application is poorly defined. A 63-year-old woman with complete atrioventricular block had persistent left ventricular septal...

An Intracellular Lysate Sustained-Release Nanohydrogel Promotes Osteogenesis and Angiogenesis

Introduction and aims Nanomaterials hold great promise for applications in bone tissue engineering. Dental pulp stem cell (DPSC) lysate, as a kind of intracellular lysate, has attracted increasing attention as a bioactive, cell-free therapeutic component in bone tissue engineerin...

An impaired excitatory-inhibitory balance in the right inferior temporal gyrus of patients with Alzheimer's disease correlated with executive function

Preliminary research indicates that an imbalance between excitation and inhibition may be an early pathological feature of Alzheimer's disease. However, the relevant brain networks, neurotransmitters and genetic mechanisms are still unclear. This study enrolled 27 patients with A...

Acupoint hot compress for labor-pain management: a randomized, parallel-group, controlled trial

Background Non-pharmacological pain management approaches, including acupoint hot compress, may provide valuable support for women dealing with pain during the latent stage of labor, but the evidence supporting this effect is limited. We investigated whether acupoint hot compress...

Prolonged growth hormone pretreatment is associated with improved embryo quality in women with poor quality embryos in previous IVF cycles

Abstract Background Approximately 10–15% of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles have most embryos of poor quality, often characterized by extensive anuclear cytoplasmic fragments. These cycles are usually associated with poor reproducti...

Longitudinal Associations Among Maternal Health Literacy, Psychological Empowerment and Health‐Promoting Behaviours in Rural Pregnant Women: A Cross‐Lagged Panel Study

AIMS: To examine longitudinal associations among maternal health literacy, psychological empowerment and health-promoting behaviours across pregnancy among rural pregnant women. DESIGN: Prospective cohort study. METHODS: Between 1 May 2023 and 15 January 2024, 694 rural pregnant...

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...

Coexistence of high-risk HPV infection and FANCC heterozygous variation in early young esophageal squamous cell carcinoma: a case report and literature review

<title>Abstract</title> <bold>Background:</bold> Esophageal cancer poses a major health challenge in China, with current screening targeting individuals over 40. However, rising incidence in younger populations, often with atypical symptoms, leads to delayed diagnosis. Investigat...

Prophylactic Low-Dose Dexamethasone for Postoperative Pulmonary Complications in Type B Aortic Dissection: A Retrospective Cohort Study

AIM: To evaluate the impact of prophylactic low-dose glucocorticoids on the incidence of postoperative pulmonary complications (PPCs) and perioperative recovery parameters in patients undergoing surgery for type B aortic dissection.METHODS: This retrospective cohort study analyze...

A unified mechano-ionic skin for resolving native electromechanical coupling

The beat-to-beat electromechanical coupling between cardiac excitation and arterial pulse propagation encodes vital cardiovascular insights, but resolving this coherence in wearables is hindered by the spatial decoupling of sensors and attenuated epidermal signals. Here, we repor...

Joint high level of low-density lipoprotein and high-sensitivity C-reactive protein are associated with early neurological deterioration after thrombolysis in patients with mild stroke

Low-density lipoprotein (LDL) and high-sensitivity C-reactive protein (hs-CRP) play important roles in cardiovascular and cerebrovascular diseases through pathways such as inflammation and oxidative stress. We aimed to explore whether LDL and hs-CRP were associated with early neu...

Ultrasmall PolymericMicelles Enable Noninvasive TransdermalRosiglitazone Delivery via Lipid Fluidization and Transcytosis

Abstract Noninvasive transdermal drug delivery (TDD) offers sustained therapeutic release but is hindered by the stratum corneum (SC) barrier. Herein, we report ultrasmall polymeric micelles (PMs) embedded in poly(vinyl alcohol) hydrogels for the passive TDD of rosiglitazone (RGT...

Direct Synthesisof Pyrazolones via N–B BondFunctionalization: Sequential Carbonyl Insertion Using In Situ Generated N , N ′-Diborylated Hydrazines

Abstract We report a metal-free protocol for the synthesis of 1,2-diaryl pyrazol-3-ones through the strategic exploitation of N,N′-diborylated hydrazine reactivity. The transformation employs a 4,4′-bipyridyl-catalyzed system that enables in situ generation of N,N′-diborylated hy...

Unraveling theR-Enantiomer Preference in Mirror-ImageCyclodextrin: An Integrated Multiscale Computational Study

Abstract L-β-Cyclodextrin (L-CD), the mirror-image isomer of native β-cyclodextrin, provides a conceptually novel chiral microenvironment for pharmaceutical enantioseparation; however, its full separation potential and recognition mechanism remain largely unexplored, hindering it...

Epidemiological Characteristics of Pediatric Drug Poisoning in Wenzhou, China in 2017–2024

To examine the evolving epidemiological characteristics of pediatric drug poisoning in Wenzhou, China from 2017 to 2024, focusing on temporal trends, age/sex-specific risks, and changes in poisoning intent and toxin types, and to generate evidence-based guidance for targeted prev...