University of Washington

A Scoping Review and Content Appraisal of Free Public Athlete Concussion Education Interventions

Abstract Health education relies on matching a program to users’ needs and preferences. Using programs aligned with expert recommendations may improve outcomes. The purpose of this study was to identify and assess free, public, concussion education programs for an athlete audienc...

Care Models for the Genetic Evaluation of Dilated Cardiomyopathy at Sites of the DCM Consortium

Abstract Background Clinical genetic evaluation for patients with dilated cardiomyopathy (DCM) is minimally implemented and models of care are not defined. To understand current genetics care for DCM, a systematic needs assessment was conducted. Methods Principal Investigators (P...

The nutritional value of invertebrate aquatic foods

Abstract Aquatic invertebrates are a diverse, nutrient-dense, and socio-ecologically important food whose contribution to human nutrition is frequently overlooked. We quantify their contribution to global nutrient supplies and estimate the nutrient content of >50,000 macroinverte...

Reimagining biomedical science workflows in the age of large language models

Abstract Large language models (LLMs) are generative artificial intelligence (AI) models that are rapidly reshaping the practice of biomedical science. Their ability to synthesize literature, generate analytical code, and interface with multimodal data offers a new framework for...

Reframing obesity in aging people with HIV: sarcopenic obesity, muscle quality, and frailty

Purpose of review As people with HIV (PWH) age, obesity is increasingly prevalent, yet body weight alone inadequately captures the functional and metabolic consequences of adverse body composition remodeling. This review examines emerging evidence supporting a shift from weight-c...

Hunting for microsatellite instability in long-read data with Owl

Abstract Microsatellite instability (MSI) is a key biomarker of mismatch repair deficiency and response to immunotherapy, yet most existing genomic detection methods are optimized for short-read sequencing and rely on small panels of homopolymer markers, limiting the ability to c...

Assessing the Validity of the Fixed Tree Topology Assumption in Phylodynamic Inference

Abstract Fixed tree topologies are widely used in phylodynamic analyses to reduce computational burden, yet the consequences of this assumption remain insufficiently understood. Here, we systematically assess the impact of various fixed-topology strategies on phylogenetic and phy...

Domain Adaptation Framework for Turning Movement Count Estimation with Limited Data

Accurate turning movement counts (TMCs) at intersections are crucial for traffic signal control, congestion mitigation, and road safety. Recent advancements in machine learning and data-driven approaches have offered promising alternatives for estimating TMCs. However, traffic pa...

An optimized product-enhanced reverse transcriptase assay for sensitive and quantitative detection of HIV viral load and phenotypic drug resistance

ABSTRACT The World Health Organization (WHO) recommends human immunodeficiency virus (HIV) drug resistance testing (DRT), but current tests are too complex and expensive for routine use. Genotypic DRT is challenging to interpret because of the growing list of mutations responsibl...

Integration of an anellovirus genome in the SKNO-1 acute myeloid leukemia cell line

ABSTRACT Anelloviruses are highly diverse, ubiquitous single-stranded DNA viruses whose replication, cellular reservoirs, and mechanisms of persistence remain poorly understood. Here, we identify and characterize a Alphatorquevirus homin 29 genome stably integrated into an rDNA l...

Disorder‐Broadened Topological Hall Phase and Anomalous Hall Scaling in FeGe

ABSTRACT Magnetic skyrmions are promising candidates for next‐generation spintronic memory and logic due to their nanoscale size and topological stability. However, skyrmion‐based devices remain limited by narrow operating temperature windows that typically exclude cryogenic regi...

Single-cell profiling identifies obesity-disrupted brain glucose sensing

Abstract Neuronal nutrient sensing in the hypothalamus and brainstem is thought to regulate energy and glucose homeostasis, yet how these brain regions respond to elevated adiposity or blood glucose remains unclear. We performed single-nucleus RNA-sequencing on 75,787 cells from...

Patient‐Specific Computational Fluid Dynamics Modeling of Airway Collapse in Infants With Robin Sequence

ABSTRACT Robin Sequence (RS) is a congenital condition in which patients experience dynamic, periodic obstruction or collapse of the upper airway due to an underdeveloped jaw and a posteriorly displaced tongue. Current clinical techniques for evaluating airway obstruction do not...

Military Service and Survival Among Persons With ALS in the U.S. National ALS Registry, 2011–2023

ABSTRACT Introduction/Aims Military service has been associated with increased risk of amyotrophic lateral sclerosis (ALS) but less is known about survival after diagnosis. We evaluated the association between military service and survival after ALS diagnosis among U.S. National...

Characteristics and Timing of Dual Pediatric Palliative Care and Ethics Consultations

Abstract Patients with serious illness hospitalized in the pediatric setting can receive support from Pediatric Palliative Care (PPC) and Ethics Consultation (EC). However, empirical data on dual PPC-EC involvement in pediatrics is limited. Therefore, we characterized ethical iss...

From frameworks to futures: health adaptation pathways across the Shared Socioeconomic Pathways

Abstract Effectively managing the rising health risks of climate change requires consideration of plausible adaptation pathways under a range of scenarios of changes in greenhouse gas emissions and socioeconomic development to systematically explore the solution space for climate...

Summary of Research: Brentuximab Vedotin and Nivolumab in Combination with Chemotherapy for Nonbulky, Early-Stage Classical Hodgkin Lymphoma

This is a summary of the original research article “Brentuximab Vedotin and Nivolumab in Combination with Chemotherapy for Nonbulky, Early-Stage Classical Hodgkin Lymphoma.” The phase 2 SGN35-027 study (NCT03646123) is a multiple-part clinical trial of brentuximab vedotin (BV), w...

Clustering of Right‐Moving Tornadic Supercell Proximity Sounding Profiles Using an Explainable Framework

Abstract This study demonstrates an explainable machine learning framework for explicitly selecting important environmental features that determine clusters of right‐moving tornadic supercells. Although previous studies have clustered and analyzed proximity sounding profiles asso...

Continued high mortality following diagnosis of HIV-associated Kaposi sarcoma in East Africa in the “Treat All” antiretroviral therapy era ― 2021-2024

Abstract Background Stage at time of diagnosis and survival after diagnosis are critical parameters regarding control of any cancer in any geographical setting. In earlier research focusing on the initial years of the “Treat All” era (2016-2019), we found that HIV-associated Kapo...

High-grade serous ovarian cancer is associated with increased TP53 mutation burden in uterine lavage

High grade serous ovarian cancer (HGSC) has low survival partly due to the lack of methods for detection, diagnosis, and risk prediction. TP53 mutations, which drive HGSC, are found in gynecological tissues as the result of somatic evolution, but it is unknown whether an excess o...