University of Washington

Hemodynamic Effects of Topical Oxymetazoline During Pediatric Flexible Bronchoscopy

BACKGROUND: Bleeding is a well-recognized complication in flexible bronchoscopy, especially with advanced procedures. Oxymetazoline is a topical vasoconstrictor often used to reduce or treat bleeding in the nares and airways. METHODS: A retrospective cohort study was conducted on...

Conservation and divergence within the Arabidopsis TPL/TPR corepressor family

Abstract The TOPLESS (TPL) and TOPLESS-RELATED (TPR1–TPR4) corepressors, collectively the Arabidopsis TPX family, are recruited by client proteins to regulate nearly every major plant regulatory program. Here, we dissect the conservation and divergence between paralogs using a co...

Modeling the combined effects of the 2023 Türkiye–Syria earthquake and an Atmospheric River event on landslide hazard

Abstract. The 6 February 2023 Türkiye–Syria earthquake doublet triggered thousands of coseismic landslides. On 14–15 March, an Atmospheric River (AR) delivered up to 183 mm of rainfall across the seismically weakened region, triggering hundreds of additional landslides and debris...

Genome folding and nuclear speckles converge to orchestrate fibroblast activation

Fibroblasts adopt diverse cell states in response to inductive cues to maintain tissue homeostasis. We leveraged this cell-state plasticity to define how genome organization contributes to changes in cellular identity. We show that TGF-β reconfigures topologically associating dom...

Sustainable Metal–Organic Framework Water Harvesters in the Artificial Intelligence Era

Abstract Metal–organic frameworks (MOFs) are promising candidates for water harvesting due to their tunable pore environments, which can be precisely engineered to capture and release water in arid conditions. Integrating artificial intelligence (AI) into MOF discovery can accele...

Synthesisand Magnetism of Silver Chromium SelenideSpinels

Abstract Chalcogenide spinels exhibit electronic and magnetic properties that are tunable through lattice occupancy and composition. Here, we report the first synthesis of spinel-phase Ag2Cr2Se4 and AgCr2Se4 and demonstrate an oxidation-induced ferro-to-ferrimagnetic transition a...

From IV to oral: clinical outcomes in Staphylococcus aureus osteomyelitis

Outcomes for patients receiving oral antibiotics for Staphylococcus aureus (SA) osteomyelitis, including methicillin-resistant SA (MRSA), are poorly characterized. We evaluated outcomes in patients treated with partial oral therapy at a public safety-net hospital. We identified o...

Assessing molecular, cellular and transcriptomic bases of laminar perfusion and cytoarchitecture coupling in the human cortex

Understanding how cellular architecture organizes cortical function requires mesoscopic approaches that resolve structure-function coupling in vivo. Here we introduce cerebral blood flow (CBF) and cell-body staining intensity (CSI) similarity index (CCSI), a localized similarity...

Vibrational Spectraof Anionic Polycyclic AromaticHydrocarbons in the CH Stretching Region: Anthracene, Pyrene, Perylene,and Fluoranthene

Abstract The CH stretching region of the infrared spectra of polycyclic aromatic hydrocarbon radical anions (2700–3100 cm–1) is characterized by complicated band patterns that defy straightforward assignments from harmonic calculations. We compare experimental infrared photodisso...

Modeling the Effects of Fermi Resonances in the CHStretching Region of the Spectra for Polycyclic Aromatic HydrocarbonAnions

A strategy is developed for evaluating spectra of anions of polycyclic aromatic hydrocarbon (PAH) molecules. The high symmetry of these systems and the similarity of the frequencies of the CH wagging and ring distortion vibrations result in normal modes that are highly mixed in c...

Validation of the AO Spine Osteoporotic Fracture Classification—effect of geographical region on reliability and reproducibility

Regional differences affect the reliability of the AO Spine-DGOU Osteoporotic Fracture Classification. European participants showed the highest agreement. This study underscores the need for addressing regional factors to improve the system’s global clinical utility. To evaluate...

Buffon discrepancy and the Steinhaus longimeter

Abstract Let be a convex set. We study the problem of distributing a one‐dimensional set with total length so that for any line in the number of intersections is proportional to the length as much as possible; we use the term Buffon discrepancy for the largest error. A constructi...

Thermohaline gradients and frontal regimes in the northwestern Tropical Atlantic

Abstract. At the edge of the Amazon River plume, stirring by the North Brazil Current (NBC) and its eddies creates sharp surface thermohaline gradients on scales of O(1–100) km. This study provides a comprehensive picture of these gradients and fronts associated with the region's...

Mucin promotes Psl production and surface exploration in Pseudomonas aeruginosa

ABSTRACT In chronic, recalcitrant infections, Pseudomonas aeruginosa forms biofilm aggregates that are encapsulated in a protective extracellular matrix made of exopolysaccharides, extracellular DNA, and matrix proteins. Biofilm formation is a major cause of antibiotic clearance...

Measuring Ocean Surface Waves

Abstract Propagating waves on the ocean surface can be represented as a stochastic process whose statistics are characterized by a spectrum. This paper reviews methods for measuring the wave spectrum and related quantities. Observations begin by sensing fluid dynamical properties...

Distribution of device-measured 24-hour movement behaviours across the cognitive spectrum in older adults: the HUNT study

Abstract Background Key daily physical activities (e.g., standing and walking), postures (sitting and lying), and sleep constitute the 24-h day and have distinct health effects and functional implications. Traditionally studied separately, the distribution of these movement behav...

Changes in neurodevelopmental outcomes from 24 to 36 months among children HIV-exposed uninfected (CHEU) and HIV-unexposed (CHU)

Objective: To compare neurodevelopment through 36 months between breastfed children who are HIV-exposed and uninfected (CHEU) exposed to maternal dolutegravir (DTG)-based antiretroviral therapy (ART) and children born to mothers without HIV (CHU). Methods: We enrolled a prospecti...

Filtering spinal cord stimulation artifacts while preserving muscle activity during exoskeleton assisted walking after spinal cord injury

Analyzing surface electromyography in the presence of transcutaneous spinal cord stimulation requires the filtering of electrical stimulation artifacts. Limitations of previous filtering approaches include the use of a uniform filter and excessive removal of muscle activity of in...

Postoperative Interventions and Cost Associated With Disposition After Tonsil and Adenoidectomy

OBJECTIVE To evaluate postoperative disposition and resource use among patients admitted to the inpatient unit or pediatric intensive care unit (PICU) following tonsillectomy, adenoidectomy, and tonsillectomy/adenoidectomy (T/A). PATIENTS AND METHODS This retrospective cohort stu...

Revisiting the Fragmentation of Ketoconazole by Positive Electrospray Ionization Tandem Mass Spectrometry and Density Functional Theory Calculations

ABSTRACT Rationale Ketoconazole (KCZ) is a clinically essential antifungal and potent CYP3A4 inhibitor. Its gas‐phase fragmentation under positive electrospray ionization tandem mass spectrometry (ESI‐MS/MS) remains poorly characterized, undermining metabolite profiling and struc...