University of Washington

Machine Learning on Heterogeneous, Edge, and Quantum Hardware for Particle Physics

The next generation of particle physics experiments will face an era of challenges in data acquisition, due to unprecedented data rates and volumes along with extreme environments and operational constraints. Harnessing these data for scientific discovery demands real-time infere...

Global Incidence of All-Cause Dementia

Importance Global dementia incidence estimates are limited by underrepresentation of low- and middle-income countries and heterogeneous analytic methods. Due to these limitations, true understanding of the global dementia landscape remains incomplete. Objective To identify dement...

Antimony 3: Extending human-readable model definitions for SBML Level 3 Core and Packages

Antimony is a human-readable language for defining and sharing models developed by the systems biology community. It enables scientists to describe biochemical networks with a simple syntax, while supporting seamless conversion to and from the Systems Biology Markup Language (SBM...

From traffic-flow capacity to recovery capacity: An episode-based framework for multi-sector urban resilience

Urban systems experience disruptions that differ in magnitude, duration, and final recovery outcome. Existing resilience measures commonly emphasize performance loss, recovery duration, or trajectory area, but they do not directly represent the peak rate at which a disrupted syst...

Development and Validation of a Coronary Artery Calcium Volume and Density Score

BACKGROUND: Coronary artery calcium (CAC) scoring is a useful tool for coronary heart disease (CHD) risk prediction. The current standard method, the Agatston score, weights plaque area upward by density. However, higher density is inversely associated with CHD. We aimed to devel...

Morphological adaptations of cervical vertebrae in plunge‐diving sulids

Abstract Foraging strategy frequently drives morphological diversification in birds. The plunge‐diving behavior of certain species makes the functional and ecological trade‐offs of variation in cervical vertebrae an especially intriguing question. This study compares cervical ver...

Improving neuropathological reconstruction fidelity via AI slice imputation

Neuropathological analyses benefit from spatially precise volumetric reconstructions that enhance anatomical delineation and improve morphometric accuracy. Prior work has shown the feasibility of reconstructing 3D brain volumes from 2D dissection photographs. However, these outpu...

Health Inequalities, Intersectionality, and Justice

Policy Points Population health science that uses large data sets to study health inequalities increasingly draws on intersectionality, the idea that overlapping forms of disadvantage shape health inequalities. This approach is essential to the pursuit of health equity because it...

Agroproductive Monitoring to Rebuild Food Systems and Strengthen One Health Outcomes in a Post-Disaster Resettlement Context in Brazil

Following the collapse of the Fundão mining tailings dam in Brazil, rural families were forcibly resettled and required to reconstruct their food systems, livelihoods and socio-ecological relationships. This case study presents an Agroproductive Monitoring Programme implemented b...

Trends in Ophthalmic Hospital Transfers and Consultations Across US Academic Centers

Importance Academic medical centers increasingly serve as a safety net for urgent and complex ophthalmic conditions, yet trends in the demand for hospital-based ophthalmic services remain poorly characterized. Objective To characterize multi-institutional trends in ophthalmology...

Prognostication in Amyotrophic Lateral Sclerosis: A Narrative Review of Pre-Diagnosis and Functional Outcomes

Amyotrophic Lateral Sclerosis (ALS) is a very heterogeneous disease, yet some of the most common questions received by physicians in the ALS clinic are “how much time do I have?” and “what can I expect to happen next?” This line of inquiry is not strictly limited to patients; cli...

Predicting Underweight Status in Infants With Cleft Lip and/or Palate in 10 US Children's Hospitals

ObjectiveTo develop and compare models predicting which infants with cleft lip and/or palate (CL/P) will be underweight at 4 months, using multicenter electronic health record data.DesignUsing data from birth to 3 months, we evaluated 63 anthropometric, clinical, healthcare-utili...

Protein‐Polymer Dynamic Hydrogels Utilizing Native Ligand Binding for Injectable Therapeutic Delivery and 3D Printing

Dynamic hydrogels comprising networks formed from reversible interactions have shown utility in minimally invasive delivery of encapsulated therapeutics, as well as in extrusion-based 3D printing of tissue-mimetic structures. Here, we report dynamic nanocolloidal hydrogels formed...

Estimating Twomey forcing sensitivity to aerosol plume spreading rates

Abstract. The amount of sunlight that reaches Earth's surface can be reduced by increasing cloud droplet number and decreasing droplet size (i.e., Twomey forcing), a central idea underpinning the Marine Cloud Brightening strategy. Cloud albedo depends nonlinearly on cloud droplet...

Near point-of-care nucleic acid amplification tests (NPOC-NAATs) using respiratory specimens for detection of pulmonary tuberculosis

RATIONALE: Near point-of-care nucleic acid amplification tests (NPOC-NAATs) are a new class of diagnostics that can be used for tuberculosis diagnosis. NPOC-NAATs are suitable for use in peripheral levels of healthcare systems as they are battery-operated instrument-based tests w...

Influenza A virus infection induces immune dysregulation in the placenta and fetus without vertical transmission in nonhuman primates

Influenza A virus (IAV) infection during pregnancy is associated with stillbirth and preterm birth. We hypothesized that maternal IAV infection disrupts placental and fetal immune networks in ways that correlate with disease severity. Pregnant pigtail macaques were inoculated wit...

Tree Rearrangement Graphs Admit Paths of Decreasing Robinson-Foulds Distance

Tree rearrangements such as Nearest Neighbor Interchange (NNI) and Subtree Prune and Regraft (SPR) are commonly used to explore phylogenetic treespace. Computing distances based on them, however, is often intractable, so the efficiently computable Robinson-Foulds (RF) distance is...

Shifting Dominant Air Pollution Sources in Sub-Saharan Africa’s Changing Urban Environment: Analysis of Elemental Composition and Source Contributions of Ambient Fine Particulate Matter (PM2.5) Pollution in Accra, Ghana

Abstract Urban and economic expansion across Sub-Saharan Africa (SSA) may be shifting the relative contributions of dominant ambient air pollution sources, influencing both pollutant concentrations and composition, along with their associated health risks. However, city-scale dat...

Hypoxia and right ventricular dysfunction in patients with acute pulmonary embolism

In patients with acute pulmonary embolism (PE), hypoxia may increase pulmonary vascular resistance and worsen right ventricular dysfunction (RVD), which is a key prognostic factor. However, associations between hypoxia, RVD and clinical outcomes have not been well described. To d...

Citron kinase activity controls alternative splicing events that drive prostate cancer growth

Prostate cancer (CaP) remains a major cause of cancer death in men, underscoring the need for mechanistically novel therapies. We previously identified the action of the mitotic kinase citron (CIT) kinase as a key driver of CaP progression and promising therapeutic target, but se...