University of Washington

Probing relaxed myosin states in hypertrophic cardiomyopathy by second harmonic-generation microscopy

This study explores the use of polarized second-harmonic generation (pSHG) to investigate myosin conformation in the relaxed state, differentiating between the actin-available, disordered (ON) state and the energy-conserving, ordered (OFF) state. By shifting the ON/OFF equilibriu...

“I know how important it is”: A qualitative analysis of participants’ experiences in a vaccine safety study

Specialist immunization clinics can support vaccination counseling for individuals experiencing adverse events following immunization (AEFIs) and research into AEFIs. We sought to describe the experiences of participants from the Canadian Special Immunization Clinic Network COVID...

Hemodynamic Effects of Topical Oxymetazoline During Pediatric Flexible Bronchoscopy

BACKGROUND: Bleeding is a well-recognized complication in flexible bronchoscopy, especially with advanced procedures. Oxymetazoline is a topical vasoconstrictor often used to reduce or treat bleeding in the nares and airways. METHODS: A retrospective cohort study was conducted on...

When the Circuit Isn't There: Establishing Absence in a Behavioral Sequence Model

Conference note: Accepted for poster presentation at the 3rd New England Mechanistic Interpretability (NEMI) Workshop, Boston University, August 14, 2026. See the NEMI Accepted Work page. 10.5281/zenodo.21970594 Motion Sequencing tokenizes mouse behavior into a fixed vocabulary o...

Glucose in Motion: Characterizing Temporal Patterns in Real-World Glycemic Control in a Large Observational Cohort

OBJECTIVE: To identify and characterize daily and weekly patterns in glycemic management in longitudinal real-world continuous glucose monitoring (CGM) data from people with diabetes to enhance clinical interpretation and support more effective personalized diabetes management. R...

Forecast-based attribution of the role of stratospheric variability in weather extremes

Abstract. Variability of the stratospheric polar vortex, particularly its dramatic breakdown during sudden stratospheric warming (SSW) events, has been linked to a number of surface weather extremes. However, attributing the role of stratospheric variability in a specific observe...

Sustainable Metal–Organic Framework Water Harvesters in the Artificial Intelligence Era

Abstract Metal–organic frameworks (MOFs) are promising candidates for water harvesting due to their tunable pore environments, which can be precisely engineered to capture and release water in arid conditions. Integrating artificial intelligence (AI) into MOF discovery can accele...

Conservation and divergence within the Arabidopsis TPL/TPR corepressor family

Abstract The TOPLESS (TPL) and TOPLESS-RELATED (TPR1–TPR4) corepressors, collectively the Arabidopsis TPX family, are recruited by client proteins to regulate nearly every major plant regulatory program. Here, we dissect the conservation and divergence between paralogs using a co...

From IV to oral: clinical outcomes in Staphylococcus aureus osteomyelitis

Outcomes for patients receiving oral antibiotics for Staphylococcus aureus (SA) osteomyelitis, including methicillin-resistant SA (MRSA), are poorly characterized. We evaluated outcomes in patients treated with partial oral therapy at a public safety-net hospital. We identified o...

Synthesisand Magnetism of Silver Chromium SelenideSpinels

Abstract Chalcogenide spinels exhibit electronic and magnetic properties that are tunable through lattice occupancy and composition. Here, we report the first synthesis of spinel-phase Ag2Cr2Se4 and AgCr2Se4 and demonstrate an oxidation-induced ferro-to-ferrimagnetic transition a...

Modeling the combined effects of the 2023 Türkiye–Syria earthquake and an Atmospheric River event on landslide hazard

Abstract. The 6 February 2023 Türkiye–Syria earthquake doublet triggered thousands of coseismic landslides. On 14–15 March, an Atmospheric River (AR) delivered up to 183 mm of rainfall across the seismically weakened region, triggering hundreds of additional landslides and debris...

Genome folding and nuclear speckles converge to orchestrate fibroblast activation

Fibroblasts adopt diverse cell states in response to inductive cues to maintain tissue homeostasis. We leveraged this cell-state plasticity to define how genome organization contributes to changes in cellular identity. We show that TGF-β reconfigures topologically associating dom...

Postoperative Interventions and Cost Associated With Disposition After Tonsil and Adenoidectomy

OBJECTIVE To evaluate postoperative disposition and resource use among patients admitted to the inpatient unit or pediatric intensive care unit (PICU) following tonsillectomy, adenoidectomy, and tonsillectomy/adenoidectomy (T/A). PATIENTS AND METHODS This retrospective cohort stu...

Changes in neurodevelopmental outcomes from 24 to 36 months among children HIV-exposed uninfected (CHEU) and HIV-unexposed (CHU)

Objective: To compare neurodevelopment through 36 months between breastfed children who are HIV-exposed and uninfected (CHEU) exposed to maternal dolutegravir (DTG)-based antiretroviral therapy (ART) and children born to mothers without HIV (CHU). Methods: We enrolled a prospecti...

Vibrational Spectraof Anionic Polycyclic AromaticHydrocarbons in the CH Stretching Region: Anthracene, Pyrene, Perylene,and Fluoranthene

Abstract The CH stretching region of the infrared spectra of polycyclic aromatic hydrocarbon radical anions (2700–3100 cm–1) is characterized by complicated band patterns that defy straightforward assignments from harmonic calculations. We compare experimental infrared photodisso...

Modeling the Effects of Fermi Resonances in the CHStretching Region of the Spectra for Polycyclic Aromatic HydrocarbonAnions

A strategy is developed for evaluating spectra of anions of polycyclic aromatic hydrocarbon (PAH) molecules. The high symmetry of these systems and the similarity of the frequencies of the CH wagging and ring distortion vibrations result in normal modes that are highly mixed in c...

Measuring Ocean Surface Waves

Abstract Propagating waves on the ocean surface can be represented as a stochastic process whose statistics are characterized by a spectrum. This paper reviews methods for measuring the wave spectrum and related quantities. Observations begin by sensing fluid dynamical properties...

Filtering spinal cord stimulation artifacts while preserving muscle activity during exoskeleton assisted walking after spinal cord injury

Analyzing surface electromyography in the presence of transcutaneous spinal cord stimulation requires the filtering of electrical stimulation artifacts. Limitations of previous filtering approaches include the use of a uniform filter and excessive removal of muscle activity of in...

Buffon discrepancy and the Steinhaus longimeter

Abstract Let be a convex set. We study the problem of distributing a one‐dimensional set with total length so that for any line in the number of intersections is proportional to the length as much as possible; we use the term Buffon discrepancy for the largest error. A constructi...

Mucin promotes Psl production and surface exploration in Pseudomonas aeruginosa

ABSTRACT In chronic, recalcitrant infections, Pseudomonas aeruginosa forms biofilm aggregates that are encapsulated in a protective extracellular matrix made of exopolysaccharides, extracellular DNA, and matrix proteins. Biofilm formation is a major cause of antibiotic clearance...