University of Washington

Resampling Fragility, Perturbation Fragility, and Why the Global Fragility Index Is Not a P-Value in Disguise

The charge that the fragility index is a P-value in disguise rests on a strong correlation between the two across trials, and it overlooks a distinction between two distinct constructs derived from the same observed result. Resampling fragility asks how often the significance ver...

Distinguishing between clinical interventions and implementation strategies in trials

Abstract Background Trialists sometimes find it difficult to determine whether the innovation they are evaluating is a clinical intervention or an implementation strategy. The inaccurate classification of innovations can lead to negative consequences such as the misspecification...

Multi-stakeholder perspectives on acceptability and delivery of buprenorphine for women who use drugs

Women who use drugs (WWUD) face substantial barriers to accessing medications for opioid use disorder (MOUD), including buprenorphine. As part of a formative evaluation to co-design a community-based intervention for MOUD delivery, we explored multi-stakeholder perspectives on th...

Survival of the Flattest: Teams with Low (But Not High) Status Differentiation Turn Failure into Success by Adding High-Status Members

Most prior research on teams’ responses to failure treats teams as closed systems. However, after failures, teams may seek to improve performance by bringing in new members. Adopting a teams-as-open-systems perspective, we test which teams are more willing to add high-status memb...

Determinants of scaled implementation for electronic laboratory information systems in 27 clinical laboratories in Côte d’Ivoire: a mixed-methods study applying the Consolidated Framework for Implementation Research (CFIR)

Abstract Background Electronic laboratory information systems (LIS) are critical for promoting data quality and improving laboratory performance, but sustained implementation following system deployment in resource-limited settings can be challenging. The OpenELIS project in Côte...

Matrix stress relaxation drives glioblastoma cell response in viscoelastic biomaterials

The extracellular matrix (ECM) of glioblastoma (GBM) is known to modulate cell behavior, yet the specific contributions of matrix biochemical and biomechanical signaling remain poorly understood. To address this, we engineer a tunable hyaluronan-elastin-like protein (HELP) hydrog...

Assessing the need for reproductive genetic counseling among adults with cystic fibrosis

Abstract Background Reproductive health has become an increasingly important focus for people with cystic fibrosis (CF), and guidelines have recommended routine inclusion of genetic counselors on care teams to address questions regarding infertility, pregnancy planning, prenatal...

MARLOWE: taxonomic characterization of unknown samples for forensics using de novo peptide identification

Abstract We present a computational tool, MARLOWE, for source organism characterization of unknown, forensic biological samples. The intent of MARLOWE is to address a gap in applying proteomics data analysis to forensic applications. MARLOWE produces a list of potential source or...

A theory of political divergence and gradual institutional change

Abstract Why do some societies succeed in breaking away from historical traditions while others remain trapped? This paper proposes a formal theory to investigate the interaction between short‐run and long‐run political dynamics, highlighting a co‐evolution of political instituti...

Accelerating protein design by scaling experimental characterization

Abstract Recent advances in de novo protein design have greatly outpaced standard protein biochemistry workflows, and experimental testing has been a bottleneck in the validation of new designs and methodologies. Here, we describe experimental and computational workflows to addre...

CS-SHRED: enhancing SHRED for robust recovery of spatiotemporal dynamics

Abstract We present CS-SHRED, a novel deep learning architecture that integrates compressed sensing (CS) into a shallow recurrent decoder (SHRED) to reconstruct spatiotemporal dynamics from incomplete, compressed or corrupted data. Our approach introduces two key innovations. Fir...

Empiric MRSA Coverage for Children with Osteoarticular Infections: 2015 to 2024

BACKGROUND AND OBJECTIVES Staphylococcus aureus is the most common causative pathogen for children with acute hematogenous osteomyelitis (AHO) and acute bacterial arthritis (ABA). National guidelines recommend empiric coverage for methicillin-resistant S. aureus (MRSA) at hospita...

Viscoelastic Response of Crosslinked Rubber: Coarse‐Grained Molecular Dynamics and Time‐Temperature Superposition

ABSTRACT The viscoelastic response of crosslinked rubber was investigated using coarse‐grained molecular dynamics simulations combined with time‐temperature superposition. Crosslinked polymer networks containing different numbers of crosslinkers were generated using a dynamic rea...

The Star Formation History and Evolution of the Ultra-Diffuse M81 Satellite F8D1

Abstract We present deep Hubble Space Telescope (HST) imaging of one of the nearest ultra-diffuse galaxies (UDGs) outside of the Local Group: F8D1, a satellite of M81 known to be tidally disrupting. UDGs are an enigmatic and diverse population, with evolutionary pathways ranging...

A Hybrid Transfer Learning Approach for Ambient PM2.5 Exposure Modeling in LMIC Contexts: A Case Study from Lima, Peru

Abstract Exposure to fine particulate matter (PM2.5) contributes to millions of premature deaths annually worldwide. While epidemiological studies increasingly rely on geospatial technologies, such as satellite remote sensing, low-cost sensors, and chemical transport models, to q...

Long-Term Fatigue After Treatment for Breast Cancer

Importance Patients with breast cancer (BC) may have long-term fatigue after treatment, which is associated with reduced quality of life. Objective To identify cardiac, psychological, and cancer treatment factors associated with fatigue before and 24 months after BC treatment. De...

When the Circuit Isn't There: Establishing Absence in a Behavioral Sequence Model

Conference note: Accepted for poster presentation at the 3rd New England Mechanistic Interpretability (NEMI) Workshop, Boston University, August 14, 2026. See the NEMI Accepted Work page. 10.5281/zenodo.21970594 Motion Sequencing tokenizes mouse behavior into a fixed vocabulary o...

“I know how important it is”: A qualitative analysis of participants’ experiences in a vaccine safety study

Specialist immunization clinics can support vaccination counseling for individuals experiencing adverse events following immunization (AEFIs) and research into AEFIs. We sought to describe the experiences of participants from the Canadian Special Immunization Clinic Network COVID...

Beyond income: financial hardship as a pathway from socioeconomic disadvantage to depression among middle and older cancer survivors

BACKGROUND: Depression disproportionately affects older cancer survivors with fewer socioeconomic resources, yet the mechanisms underlying this disparity remain under-explored. Guided by Fundamental Cause Theory, this study examined whether financial hardship mediates the relatio...

When the Circuit Isn't There: Establishing Absence in a Behavioral Sequence Model

Conference note: Accepted for poster presentation at the 3rd New England Mechanistic Interpretability (NEMI) Workshop, Boston University, August 14, 2026. See the NEMI Accepted Work page. 10.5281/zenodo.21970594 Motion Sequencing tokenizes mouse behavior into a fixed vocabulary o...