University of Washington

Matrix stress relaxation drives glioblastoma cell response in viscoelastic biomaterials

The extracellular matrix (ECM) of glioblastoma (GBM) is known to modulate cell behavior, yet the specific contributions of matrix biochemical and biomechanical signaling remain poorly understood. To address this, we engineer a tunable hyaluronan-elastin-like protein (HELP) hydrog...

Determinants of scaled implementation for electronic laboratory information systems in 27 clinical laboratories in Côte d’Ivoire: a mixed-methods study applying the Consolidated Framework for Implementation Research (CFIR)

Abstract Background Electronic laboratory information systems (LIS) are critical for promoting data quality and improving laboratory performance, but sustained implementation following system deployment in resource-limited settings can be challenging. The OpenELIS project in Côte...

A theory of political divergence and gradual institutional change

Abstract Why do some societies succeed in breaking away from historical traditions while others remain trapped? This paper proposes a formal theory to investigate the interaction between short‐run and long‐run political dynamics, highlighting a co‐evolution of political instituti...

MARLOWE: taxonomic characterization of unknown samples for forensics using de novo peptide identification

Abstract We present a computational tool, MARLOWE, for source organism characterization of unknown, forensic biological samples. The intent of MARLOWE is to address a gap in applying proteomics data analysis to forensic applications. MARLOWE produces a list of potential source or...

Accelerating protein design by scaling experimental characterization

Abstract Recent advances in de novo protein design have greatly outpaced standard protein biochemistry workflows, and experimental testing has been a bottleneck in the validation of new designs and methodologies. Here, we describe experimental and computational workflows to addre...

Empiric MRSA Coverage for Children with Osteoarticular Infections: 2015 to 2024

BACKGROUND AND OBJECTIVES Staphylococcus aureus is the most common causative pathogen for children with acute hematogenous osteomyelitis (AHO) and acute bacterial arthritis (ABA). National guidelines recommend empiric coverage for methicillin-resistant S. aureus (MRSA) at hospita...

CS-SHRED: enhancing SHRED for robust recovery of spatiotemporal dynamics

Abstract We present CS-SHRED, a novel deep learning architecture that integrates compressed sensing (CS) into a shallow recurrent decoder (SHRED) to reconstruct spatiotemporal dynamics from incomplete, compressed or corrupted data. Our approach introduces two key innovations. Fir...

A Hybrid Transfer Learning Approach for Ambient PM2.5 Exposure Modeling in LMIC Contexts: A Case Study from Lima, Peru

Abstract Exposure to fine particulate matter (PM2.5) contributes to millions of premature deaths annually worldwide. While epidemiological studies increasingly rely on geospatial technologies, such as satellite remote sensing, low-cost sensors, and chemical transport models, to q...

Long-Term Fatigue After Treatment for Breast Cancer

Importance Patients with breast cancer (BC) may have long-term fatigue after treatment, which is associated with reduced quality of life. Objective To identify cardiac, psychological, and cancer treatment factors associated with fatigue before and 24 months after BC treatment. De...

Viscoelastic Response of Crosslinked Rubber: Coarse‐Grained Molecular Dynamics and Time‐Temperature Superposition

ABSTRACT The viscoelastic response of crosslinked rubber was investigated using coarse‐grained molecular dynamics simulations combined with time‐temperature superposition. Crosslinked polymer networks containing different numbers of crosslinkers were generated using a dynamic rea...

The Star Formation History and Evolution of the Ultra-Diffuse M81 Satellite F8D1

Abstract We present deep Hubble Space Telescope (HST) imaging of one of the nearest ultra-diffuse galaxies (UDGs) outside of the Local Group: F8D1, a satellite of M81 known to be tidally disrupting. UDGs are an enigmatic and diverse population, with evolutionary pathways ranging...

Beyond income: financial hardship as a pathway from socioeconomic disadvantage to depression among middle and older cancer survivors

BACKGROUND: Depression disproportionately affects older cancer survivors with fewer socioeconomic resources, yet the mechanisms underlying this disparity remain under-explored. Guided by Fundamental Cause Theory, this study examined whether financial hardship mediates the relatio...

When the Circuit Isn't There: Establishing Absence in a Behavioral Sequence Model

Conference note: Accepted for poster presentation at the 3rd New England Mechanistic Interpretability (NEMI) Workshop, Boston University, August 14, 2026. See the NEMI Accepted Work page. 10.5281/zenodo.21970594 Motion Sequencing tokenizes mouse behavior into a fixed vocabulary o...

When the Circuit Isn't There: Establishing Absence in a Behavioral Sequence Model

Conference note: Accepted for poster presentation at the 3rd New England Mechanistic Interpretability (NEMI) Workshop, Boston University, August 14, 2026. See the NEMI Accepted Work page. 10.5281/zenodo.21970594 Motion Sequencing tokenizes mouse behavior into a fixed vocabulary o...

Wavelength Requirements for Life Detection via Reflected Light Spectroscopy of Rocky Exoplanets

Searching for signs of life is a primary goal of the Habitable Worlds Observatory (HWO). However, merely detecting oxygen, methane, or other widely discussed biosignatures is insufficient evidence for a biosphere. In parallel with biosignature detection, exoplanet life detection...

Forecast-based attribution of the role of stratospheric variability in weather extremes

Abstract. Variability of the stratospheric polar vortex, particularly its dramatic breakdown during sudden stratospheric warming (SSW) events, has been linked to a number of surface weather extremes. However, attributing the role of stratospheric variability in a specific observe...

Subspace Langevin Monte Carlo

Abstract. Sampling from high-dimensional distributions has wide applications in data science and machine learning but poses significant computational challenges. We introduce subspace Langevin Monte Carlo (SLMC), a novel and efficient sampling method that generalizes random-coord...

Glucose in Motion: Characterizing Temporal Patterns in Real-World Glycemic Control in a Large Observational Cohort

OBJECTIVE: To identify and characterize daily and weekly patterns in glycemic management in longitudinal real-world continuous glucose monitoring (CGM) data from people with diabetes to enhance clinical interpretation and support more effective personalized diabetes management. R...

Probing relaxed myosin states in hypertrophic cardiomyopathy by second harmonic-generation microscopy

This study explores the use of polarized second-harmonic generation (pSHG) to investigate myosin conformation in the relaxed state, differentiating between the actin-available, disordered (ON) state and the energy-conserving, ordered (OFF) state. By shifting the ON/OFF equilibriu...

“I know how important it is”: A qualitative analysis of participants’ experiences in a vaccine safety study

Specialist immunization clinics can support vaccination counseling for individuals experiencing adverse events following immunization (AEFIs) and research into AEFIs. We sought to describe the experiences of participants from the Canadian Special Immunization Clinic Network COVID...