University of Toronto

Stellar discs and intermediate-mass black holes in galactic nuclei – I. Fragmenting the disc in an isotropic stellar potential

Abstract The origin of the complex orbital structure of young massive stars at the Galactic centre remains an open question. If these stars formed in a single episode from a gaseous accretion disc, they may initially have constituted a single, coherently rotating stellar disc. We...

Parent Perspectives on Adolescent Gender-Based Violence as a Public Health Issue in Medellín, Colombia: A Qualitative Study

Introduction Gender-based violence (GBV) is a major public health concern affecting adolescents across Latin America. Yet, little is known about how parents, as key figures in adolescents’ social environments, understand these risks. This study explored parental perspectives on a...

Exploring pathways and barriers to wellbeing for racialized communities in public greenspaces: a photovoice study in Toronto, Canada

The presumption that all people experience greenspaces in the same ways and accrue universally positive impacts on health may inadvertently perpetuate social, environmental, and health inequities and uphold systemic barriers to wellbeing. The Park Perceptions and Racialized Reali...

Storytelling as a public health competency: a call for training that responds to contemporary challenges

Public health has long emphasized letting quantitative data “tell the story”. Large, representative datasets allow researchers to answer questions about disease occurrence, risk, and interventions with rigor and precision. Yet, for many small, heterogeneous, historically-neglecte...

How precariously employed gay, bisexual, and queer immigrant and refugee men in Toronto make meaning of work, health, and wellbeing

Abstract Lesbian, gay, bisexual, transgender, and queer (LGBTQ+) people experience mental health and trauma outcomes as a result of systemic exclusion from the labour market in Canada, with less known about intersectional labour precarity for LGBTQ+ immigrants. How LGBTQ+ immigra...

Reduction of CXCR3 + CCR6 + CD4 + T Cells and IL ‐17+ RORγt + CD4 + T Cells During Secukinumab Treatment Identifies Patients With Axial Spondyloarthritis Responsive to Subsequent Biologic Therapy

OBJECTIVE: We recently reported an immune profile that stratifies patients with axial spondyloarthritis based on clinical response to secukinumab. We now undertake an exploratory study on the secukinumab nonresponder patients to determine if immunologic changes occur during their...

A Paint Library of Plastic Particles (PLoPP): a spectral library, visual key, and machine learning model for paint microplastic identification

The degradation of paint is thought to be a major pathway of microplastics to the environment. However, pollution from paint microplastics is challenging to assess due to a lack of paint-specific spectral libraries and visual keys to aid in the differentiation of paint microplast...

Customer-level factors associated with discretionary food and beverage purchasing in Aboriginal and Torres Strait Islander community stores in remote Australia: a customer intercept survey of Healthy Stores 2020

Abstract Background Healthy Stores 2020 (HS2020), a 12-week randomised controlled trial conducted in partnership with an Aboriginal-owned retail organisation, reduced retailer merchandising and store-level purchases of unhealthy foods. Evidence on the influence of customer-level...

Understanding the Research Needs and Educational Methods of Surgeons to Help Guide Future Spine Deformity Research: A Survey of AO Spine Members

Study Design Cross-sectional survey. Objective Outcomes research has significantly shaped patient management in spine deformity care, while the dissemination of research remains a challenge. To guide future research directions, this study surveyed AO Spine members to identify the...

Manipulation-Robust Prediction

An increasing number of decisions are guided by machine learning algorithms. But when consequential decisions are encoded in algorithms, individuals may strategically alter their behavior to achieve desired outcomes. This paper develops an empirical approach that adjusts decision...

Living With Chronic Pain: A Narrative Inquiry Into Identity Reconfiguration Among Canadian Veterans—A Research Note

Approximately one-third of Canadian Veterans live with chronic pain, which can profoundly disrupt identity as they transition to civilian life. Little is known about how chronic pain reshapes the moral and embodied dimensions of military identity. Using narrative inquiry, semi-st...

Imaging manifestations of malignancy in inflammatory bowel disease: patterns, pitfalls and pearls

Patients with inflammatory bowel disease (IBD) are at increased risk of gastrointestinal and hepatobiliary malignancies arising in the setting of chronic inflammation, dysplasia, stricturing disease, and fistulizing complications. Although endoscopic surveillance remains the corn...

HIV and STI Co-infection and Migration-Related Social Vulnerability among Venezuelan Gay and Bisexual Migrants in Lima, Peru

BACKGROUND: This study examined HIV, bacterial STI co-infection, and migration-related vulnerability among Venezuelan gay, bisexual, and other men who have sex with men (GBM) in Lima, Peru. METHODS: A total of 306 Venezuelan GBM of any serostatus living in Lima, Peru, were recrui...

The efficacy of ketogenic interventions on neuropsychological & metabolic outcomes in serious mental illness & neurocognitive disorders: a systematic review & meta-analysis

Ketogenic interventions have garnered attention for their potential benefits in individuals with psychiatric and neurocognitive disorders. This review analyzed findings from studies investigating the impact of ketogenic interventions on clinical outcomes in individuals with serio...

Who gets the curb? A systematic review of responsive curb management research

Urban curb space is a capacity-constrained resource that serves different user groups, including freight deliveries, ride-hailing, transit access, paratransit, and short-term parking, yet in most cities it is still governed by static rules and fixed signage. Emerging data sources...

Comparative study of ensemble-based uncertainty quantification methods for neural network interatomic potentials

Abstract Machine learning interatomic potentials (MLIPs) enable atomistic simulations with near first-principles accuracy at substantially reduced computational cost, making them powerful tools for large-scale materials modeling. The accuracy of MLIPs is typically validated on a...

Expanding Remote Patient Monitoring for Pre‐Lung Transplant Candidates With Interstitial Lung Disease

ABSTRACT Introduction Interstitial lung disease (ILD) is a primary indication for lung transplantation (LTx). Close monitoring of disease progression informs transplant urgency, timing, medical and pre‐habilitation management, and remote home monitoring may support frequent asses...

Pharmacokinetics of phosphodiesterase type 5 inhibitors and β-adrenergic receptor type 3 agonists for benign prostatic hyperplasia

Introduction Benign prostatic hyperplasia (BPH) is amongst the most common conditions affecting aging men, with resulting lower urinary tract symptoms (LUTS) impeding on quality of life. While many medication classes exist for treatment of LUTS secondary to BPH, their increasing...

Nonviral delivery of chemically modified tRNA rescues nonsense mutations in cystic fibrosis

Suppressor transfer RNAs (sup-tRNAs) can rescue disease-causing nonsense mutations by promoting readthrough of premature termination codons (PTCs). Their clinical translation is limited by suboptimal activity and inefficient in vivo delivery. In this work, we combined site-specif...

Constant-Factor Algorithms for Revenue Management with Consecutive Stays

Constant-Factor Policies for Consecutive-Stay Bookings Railway operators and hotels must decide whether to accept bookings while preserving capacity for future customers. In “Constant-Factor Algorithms for Revenue Management with Consecutive Stays,” Hu and Wu study this challenge...