University of Toronto

Readability and Quality of Online Patient Education Materials: Thyroid Radiofrequency Ablation

OBJECTIVE: To assess the readability and quality of online patient education materials regarding thyroid radiofrequency ablation. METHODS: Google searches were conducted using six search terms related to thyroid radiofrequency ablation, and the top 50 webpages from each search we...

Three-dimensional reconfigurable magnetic microswarms with boundary-transcending capabilities

Swarm behaviors are prevalent in nature and have inspired many engineering designs. However, achieving artificial swarms capable of reversibly migrating through fluids against gravity and transcending physical boundaries, such as solid–liquid and liquid-air interfaces, remains ch...

Clinical, Allied Health, and Research/Advocacy Professionals’ Perspectives on Body Image and Support Needs for Young Adults with Cancer; A Qualitative Study

. Participants identified the need for tailored, patient centred care, peer support and better professional training to address BI distress in YAC. Support should be timely, adaptable to individual needs and sustained across the care pathway.

The triple rendezvous time of a synchronizing automaton can be floor(4n/3)

For every n >= 9 we construct a strongly connected synchronizing automaton with two letters and n states whose shortest word merging some three distinct states has length floor(4n/3). One letter is a permutation, and the other has rank n-1. Complete transition maps and three para...

Spatially guided translation from histology images to transcriptomic profiles using foundation model-driven contrastive learning

Spatial transcriptomics (ST) enhances single-cell RNA sequencing by revealing transcript distribution, offering critical insights into heterogeneous diseases such as breast cancer. However, the high cost and lengthy processes of generating high-quality ST data limit clinical appl...

Comparison of alkali-silica reaction mitigation between supersulfated cement and Portland cement

Deleterious alkali-silica reaction (ASR) in concrete occurs between alkaline ions and reactive minerals present in aggregates. Studies with Portland cement (PC) have shown that alumina can help form a protective film that surrounds the aggregate and hinders the dissolution of rea...

Contemporary Fibrotic Interstitial Lung Disease Outcomes: A Multicentre National Cohort Study

ABSTRACT Background and Objective This study determined contemporary transplant‐free survival in fibrotic interstitial lung disease (ILD), identified baseline factors associated with death or transplant, and assessed performance of the ILD‐GAP (Gender, Age, Physiology) index in a...

Obywatel Michnik: myśl polityczna Adama Michnika

Adam Michnik is one of the most prominent Polish politicians and intellectual leaders of the late twentieth and early twenty-first centuries. His contribution to Poland’s independence and democrati...

Sex differences in concussion incidence before and during the COVID-19 pandemic: a population-based study (2017–2022)

OBJECTIVES: This population-based retrospective study investigated the impact of sex on annual case counts and incidence rates of concussions before and during COVID-19 pandemic. METHODS: Using administrative data from ICES, we identified 393,397 individuals with concussion betwe...

One of the Best Parts – Workplace Walk-Throughs: Findings from a 2025 Canadian Survey of Physicians Practicing in Occupational Medicine

Objective: Workplace walk-throughs (WWs) are a sine qua non for gaining experience on how workplace hazards affect health. This study examines physicians’ experiences participating in WWs. Methods: This cross-sectional study examined responses from a module on WWs in a 2025 onlin...

Presumptive Coverage Policies and Workers’ Compensation of Post‐Traumatic Stress Disorder and Other Mental Health Conditions: A Retrospective Time‐Series Study in Canada 2001–2019

BACKGROUND: The impact of presumptive coverage policies for work-related mental health disorders has not been extensively studied to date. Using data from the Association of Workers' Compensation Boards of Canada (AWCBC), our objectives were to describe the evolution of compensat...

Augmented reality for hand function rehabilitation: assessing perceptions of feasibility and meaningfulness among individuals with cervical spinal cord injury

Abstract Background: Creating high-quality, home-based rehabilitation tools is integral for hand function recovery among individuals living with cervical spinal cord injury (cSCI). Specifically, the effectiveness of home-based exercises is limited by compliance issues and a lack...

Synthesis and Application of 3,3-Difluoro Sialic Acid as a Sialyltransferase and Neuraminidase Inhibitor

Abstract Sialic acid (Neu5Ac) is a monosaccharide terminating glycoconjugates, serving as ligands for lectins in health and disease. Tools to target sialyltransferases (STs) and neuraminidases (NEUs) are important in the study of sialoglycans. 3FaxNeu5Ac is a common ST inhibitor,...

ATAD2 is a novel regulator of myogenesis and autophagy in skeletal muscles

Abstract The nuclear protein ATAD2 (ATPase family AAA domain containing 2) is a known positive regulator of cell proliferation in various cancer types. The expression and functional roles of ATAD2 in skeletal muscle cells are unknown. In this study, we used transient and stable k...

Quantitative assessment of national essential medicines lists processes: a descriptive study of 143 countries

The National Essential Medicines List (NEML) selection process is a foundational component of an essential medicines based policy, and the NEML itself is a key policy tool. The World Health Organization (WHO) provides guidance for policy development that aligns with the Accountab...

Framing the Canadian Health Technology Assessment as an Organisational Process: A Bibliometric Analysis

ABSTRACT Health Technology Assessment (HTA) is an organizational process used to determine the value of health‐technologies. There is considerable variation in how HTA is developed globally, with Canada at the forefront of this field, having pioneered the use of HTA and implement...

Coupling of hydrological drought and flood extremes under climate change in the Kamp catchment, Austria

Study region Kamp catchment, Austria Study focus This study developed a comprehensive framework to assess consecutive hydrological drought-to-flood (D-F) events. The framework integrates a performance-based selection of ÖKS15 climate projections for RCP2.6, RCP4.5, and RCP8.5, hy...

Genomic response to sex-separated gene pools

ABSTRACT Males and females experience differences in the strength and direction of selection but discerning the type of genes that are targets of sex differences in selection is complicated by their shared genome. We used experimental evolution in Drosophila melanogaster to parti...

Beyond in silico prediction: multi-omics to identify a pathogenic deep intronic HNRNPK variant in Au-Kline syndrome

Abstract Pathogenic variants in HNRNPK are associated with autosomal dominant Au-Kline syndrome (AKS, Au-Kline-Okamoto syndrome, OMIM #616580). This syndrome is characterized by developmental delay and intellectual disability, hypotonia, and distinctive facial features. Despite t...

Trends in HIV prevention outcomes among Northern and Indigenous adolescents: A repeated cross-sectional study of arts-based sexual health workshops in the Northwest Territories, Canada

Background: Arts-based sexual health workshops may improve adolescent sexual health, yet limited studies have evaluated outcome trends over time. This study examined HIV prevention outcomes before and after school-based workshop participation among adolescents in the Northwest Te...