University of Toronto

Focal Therapy for Prostate Cancer

This retrospective study uses data from the National Cancer Database to examine patterns and temporal trends in use of focal therapy for prostate cancer in US cancer centers; characterize inappropriate use in low-, high-, or very–high-risk disease; and describe intermediate-risk...

MetaboSense: An Integrated Quantum Dot‐Mediated Aptamer Assay and Modular Microfluidic Platform for Continuous In‐Line Monitoring of Lung Metabolism During Ex Vivo Perfusion

ABSTRACT Organ transplantation provides a life‐saving intervention for patients with end‐stage lung disease; however, access to this treatment remains limited by the shortage of donor organs. Ex vivo lung perfusion (EVLP) is a platform that enables surgeons to assess extended‐cri...

Data-driven mapping of known and novel fluid biomarker progression profiles in genetic frontotemporal lobar degeneration

Abstract Introduction Recent proteomic studies have identified both established and novel proteins in genetic frontotemporal lobar degeneration (FTLD). However, it remains unclear at what point in the disease these proteins deviate from normal levels and how their trajectories re...

Generative AI for Hospital Cybersecurity: A Framework for Evaluating Large Language Models for Planning, Threat Detection, and Incident Response

The increasing digitization of healthcare records and growing reliance on interconnected systems have increased hospitals’ exposure to cyber threats, including ransomware, brute-force attacks, and Structured Query Language (SQL) injection. Traditional cybersecurity approaches alo...

Hospitalization of Children in Foster Homes: A Canadian Cohort Study

BACKGROUND AND OBJECTIVES: In Canada, approximately 4% to 7% of children live in a foster home during their childhood. This study reports on hospitalizations of children in foster homes, with the hypothesis that rates of hospitalization are higher for children with foster home ex...

Machine learning for early prediction of preterm birth

Abstract Background Preterm birth (PTB), defined as delivery before 37 completed weeks of gestation, remains a major cause of neonatal mortality and long-term morbidity worldwide. Conventional risk assessment strategies, including cervical length measurement and biomarker-based s...

Evaluating the costs of developing a digital supervision tool for task-shared depression care: findings from a multi-site study in India

BACKGROUND: Task-sharing with non-specialist providers offers a promising solution to the mental health workforce shortage in low-resource settings. Supervision is essential to ensure treatment quality, but is often constrained by limited specialist availability. AIMS: This study...

The Association Between Intranasal Steroids and Length of Stay in Children With Orbital Infections

OBJECTIVE: Little is known about the use of intranasal agents in the management of orbital infections in children. This study aims to describe intranasal corticosteroid use in children hospitalized with orbital infections and to determine whether an association exists between int...

Gold‐Stabilized Copper Enables Anodic Hydrogen Evolution for Ultralow‐Voltage CO‐to‐Ethylene Electrolysis

ABSTRACT Electrochemical upgrading from CO 2 and CO to ethylene has typically been coupled with the oxygen evolution reaction (OER), whose high standard reduction potential leads to full‐cell voltages above 2.2 V at 200 mA/cm 2 . Here we explored an alternative anodic reaction, w...

Discovery andCharacterization of RP04340 : A Highly Potent and OrallyActive Pan-KRAS PROTAC Degrader

Abstract Targeting diverse KRAS mutations with a single agent remains a significant challenge in oncology. Here, we report the discovery and characterization of RP04340, a potent and orally bioavailable pan-KRAS PROTAC degrader. Starting with a structure-based pan-KRAS inhibitor...

A decision-tree for trend analyses following major survey redesigns: an analysis using the Canadian Community Health Survey (CCHS)

Abstract Background Monitoring health inequality trends is essential for assessing progress, stagnation, or regression on the reduction of health inequalities; assessing the impact of certain policies on health inequalities; and identifying emerging areas of concern. Because ineq...

Sowing the Seeds of Sovereignty: A One Health Case Study of Food, Relationships, and Resilience in Somalia

Abstract In Somalia, food insecurity has been shaped by recurrent droughts and climate change, violent conflict, and political instability. For over 35 years, these drivers have undermined local food system autonomy, disrupted economic sovereignty, and entrenched dependence on in...

Patient-physician sex concordance and real-world disparities in cancer treatment practices and outcomes in medical oncology

The impact of sex inequities in healthcare may be magnified in medical oncology, where patients and physicians often navigate life-limiting illnesses and intensive treatments. We examined the associations among patient-physician sex concordance, treatment practices, and cancer ou...

Institutional Outcomes of Immediate vs Delayed or No Clean Intermittent Catheterization in Infant Neurogenic Bladder

BACKGROUND: Timing of clean intermittent catheterization (CIC) in infants with neurogenic lower urinary tract dysfunction (NLUTD) remains uncertain. We compared 12-month infectious and renal-bladder ultrasound (RBUS) outcomes in infants started on CIC within 30 days of life versu...

Association Between Dextromethorphan/Bupropion with Diabetes Mellitus and Hyperglycemia: Reports to the Food and Drug Administration Adverse Event Reporting System (FAERS)

IntroductionDextromethorphan/bupropion (DXM/BUP) is the first orally administered antidepressant approved by the United States Food and Drug Administration (U.S. FDA) that combines dextromethorphan (i.e., a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist and sigma...

A cross-national study examining social determinant factors on short sleep between the U.S. and Canada

Sleep is essential for optimal health as short sleep is associated with cardiovascular disease, diabetes, and early mortality. One-third of adults in the U.S. and Canada do not receive sufficient sleep. Canadian adults are typically healthier than U.S. adults and inequities in sl...

Papillary Fibroelastoma Causing Large-Vessel Ischemic Stroke in a Young Patient: Histopathologically Confirmed Tumor Embolism Treated With Mechanical Thrombectomy

Papillary fibroelastoma (PFE) is a benign cardiac tumor that, despite having significant embolic potential, is typically an uncommon cause of large-vessel ischemic stroke. We report a 19-year-old female who presented with acute aphasia and right hemiplegia due to a left middle ce...

Failed metabolic adaptation to stress contributes to epidermal cell adhesion defects in Darier disease

Congenital pathogenic gene variants may not elicit symptoms until later in life, highlighting the importance of identifying extra-genetic factors influencing the onset and severity of heritable diseases. We explored this in Darier disease (DD or ATP2A2 -nEDD), an autosomal domina...

Linking Magmatism and Gold Mineralization at the Fenelon Gold Deposit, Northern Abitibi, Canada: Insights from Pyrite Chemistry, U-Pb and Re-Os Geochronology

Abstract The Fenelon gold deposit, located in the underexplored northern region of the Abitibi greenstone belt, hosts an estimated 4.09 Moz at 3.20 g/t Au and is spatially associated with the 2697 ± 0.96 Ma Jeremie diorite (isotope dilution-thermal ionization mass spectrometry [I...

Prevalence and Characteristics of Long-Stay Forensic Patients With Intellectual and Developmental Disabilities: An Ontario Population-Based Study: Prévalence et caractéristiques des patients hospitalisés pour de longs séjours dans un service médico-légal et présentant des déficiences intellectuelles et développementales : Une étude fondée sur la population de l’Ontario

Objectives This study examined the point prevalence of patients with intellectual and developmental disabilities (IDDs) in Ontario forensic inpatient units and compared the demographic, clinical, and system-level profiles of long-stay forensic patients with and without IDD. Metho...