University of Pennsylvania

Organizational determinants of burnout among hospital‐based nurse practitioners: A structural equation modeling analysis

Abstract Background The nurse practitioner (NP) workforce is rapidly expanding in hospital settings, yet limited evidence exists on how organizational practice environments influence NP burnout. Identifying modifiable workplace factors is critical to improving NP well‐being and r...

Self-Catalyzed Transesterification Transforms Ionizable Amphiphilic Janus Dendrimers into Multicomponent Vectors and Generates Complex Design Strategies for mRNA Delivery

Abstract Genetic nanomedicine delivers nucleic acids by viral and synthetic vectors to produce drugs directly in the body’s own cells. Each approach presents relative advantages, but synthetic vectors are distinguished by their effectively unlimited synthetic capabilities. The le...

Evaluating a smartphone intervention to improve HIV prevention and care outcomes: results from the HealthMPowerment national randomized controlled trial

HealthMPowerment (HMP) is a digital intervention designed to improve HIV-related outcomes among young Black and Latinx men who have sex with men (YBLMSM) and transgender women (TW). We conducted a 12-month randomized controlled trial to evaluate HMP’s impact on routine HIV testin...

What Can a Badge Do? A Pilot Study of the Vot-ER Badge in a Community Health Setting

Civic engagement is an important example of health and health care inequity in the United States, with voting being an active form of civic engagement that allows citizens to be involved in the political processes that directly impact their health. Existing literature indicates t...

SLC7A6OS Founder Mutation: A Rare Cause of Progressive Myoclonus Epilepsy Dated to 1100 Years Ago

BACKGROUND: SLC7A6OS c.191A>G is a rare, autosomal recessive cause of progressive myoclonus epilepsy (PME). The c.191A>G variant, first discovered in two families from Türkiye and Portugal, was recently identified in three additional probands from the USA, all of Puerto Rican anc...

Metabolic heterogeneity in the risk of cancer among patients with cardiovascular diseases and diabetes

The co-occurrence of cardiovascular diseases (CVDs) and cancer may worsen patient outcomes and burden the healthcare system. We aimed to evaluate metabolic patterns of cancer risk and to characterize the heterogeneity of such an association across cancer and CVD subtypes. We anal...

Disparities in Blood Pressure Measurement

Abstract Purpose of review We aimed to examine how inaccuracies and inequities in blood pressure (BP) measurement across office, ambulatory, home, and emerging cuffless modalities contribute to disparities in hypertension diagnosis and control, and to identify strategies to impro...

Warmed intravenous fluid administration attenuated a reduction in body temperature in anaesthetised horses

Abstract Background Peri‐anaesthetic hypothermia is a well‐documented complication of general anaesthesia and is associated with prolonged recovery, impaired wound healing, and delayed coagulation. Fluid warmers can be used to mitigate heat loss, but there is little evidence supp...

Patient-reported Outcomes Measurement Information System Score Analysis in Diagnosis and Treatment Evaluation of Pediatric Disc Herniation Patients: A Preliminary Study

BACKGROUND: Compared with adults, children with intervertebral disc herniation often face delayed diagnoses due to atypical presentations and symptom overlap with other musculoskeletal disorders. While non-operative treatments such as physical therapy and NSAIDs are typically fir...

Unidirectional flow from continuous broken symmetries

Locally broken symmetries are used across fields to transport matter, particles, and information in preferential directions. Beyond local mechanisms, spatially distributed nonlinearities in crystalline media have enabled nonreciprocal transport, a rectification mechanism that ope...

PriME: Privacy-Aware Membership Profile Estimation in Networks

Abstract. This paper presents a novel approach to estimating communbity membership probabilities for network vertices generated by the degree corrected mixed membership stochastic lock model [ 36 ] while preserving individual edge privacy. Operating within the [Formula: see text]...

Antihypertensive Treatment and Risk of Metabolic Associated Fatty Liver Disease: A Drug-Target Mendelian Randomization

BACKGROUND: Metabolic dysfunction-associated fatty liver disease, conventionally known as nonalcoholic fatty liver disease (NAFLD), affects over a quarter of the global population and lacks approved pharmacological treatments. We investigated whether elevated blood pressure (BP)...

Co-designing for social studies teacher learning: lessons from a six-year research−practice partnership

Purpose To date, little research examines what happens when co-design aims not at student-facing curriculum but, rather, at the development of teacher learning and professional development experiences. Given the success of co-design methods in promoting instructional innovation a...

Do Autistic Adolescents Talk Differently in Same-Sex Versus Mixed-Sex Conversations?

Autistic individuals often struggle with social communication, but the nature of each person’s difficulties varies substantially by context. Recent conversation-based research suggests that males and females (autistic and nonautistic) produce subtle but consistent differences in...

Trends in trajectories and incidence of functional impairment in middle-aged Americans

The prevalence of functional impairment (i.e., difficulty performing daily activities such as bathing and dressing) has increased among middle-aged Americans, but longitudinal data are lacking. The objective of this study was to examine trajectories of functional status and incid...

Impact of Voice Onset Time on Phoneme Perception and Implications for a Language-Agnostic Hearing Assessment

Purpose: The aim of this study was to evaluate the effect of native language on phoneme perception in normal-hearing (NH) adults representing the three most commonly spoken languages in the United States (English, Spanish, and Mandarin Chinese). Method: A prospective cross-sectio...

Increasing Rounds Participation for Caregivers Who Prefer a Language Other Than English

OBJECTIVES: For patients admitted to our hospital medicine resident services, we found that caregivers who were present at bedside and who preferred a language other than English (LOE) participated in family-centered rounds (FCRs) 53% of the time compared with 92% for English-pre...

Precision Medicine 3.0: Integrating Genomic Stratification with Adaptive Therapeutic Trajectories

Complex diseases require therapeutic decisions that adapt as the disease evolves over time and in response to treatment. Current precision medicine remains largely centered on selecting an individual drug or predefined regimen from molecular characteristics measured at a particul...

Sex-specific biological aging clocks across organs and omics

Sex differentially shapes aging, neurodevelopment and neurodegenerative diseases such as Alzheimer’s disease (AD). However, most biological aging clocks (artificial intelligence-predicted age minus chronological age) were trained on sex-pooled samples and implicitly assume sex in...

Microglia modulate concussion biomarkers and cognitive recovery in male mice

There is a critical unmet need for concussion biomarkers that predict cognitive recovery. Existing TBI biomarkers largely capture acute cellular damage rather than the multicellular repair processes that determine long-term outcome, and whether microglia causally shape divergent...