University of Pennsylvania

PTPN2 sustains non-canonical inflammasome activation and shapes the inflammatory response to sepsis

Abstract The innate immune system relies on pattern recognition receptors to recognize and detect pathogens. Gram-negative bacteria release LPS-rich outer membrane vesicles (LPS-OMVs), which activate PRRs, trigger inflammation at distant sites and contribute to systemic inflammat...

Anticoagulation Treatment Response Among Phenotypic ESUS Clusters: Evidence From CASPR

ABSTRACT Objective To evaluate treatment effect heterogeneity across phenotypic clusters of patients with cryptogenic embolic stroke using causal inference methods. Methods From a retrospective, multicenter cohort of patients with cryptogenic embolic stroke, we estimated the trea...

CfDNA methylation profiling in blood following moderate-to-severe traumatic brain injury using brain cell type–enriched signatures: A pilot study

The human brain consists of diverse cell types that collaboratively perform complex functions and form intricate neuronal networks. When traumatic brain injury (TBI) occurs, multiple molecular pathways involving diverse cell types are activated in response to injury. Understandin...

Clinical Trial: Dupilumab Improves Eosinophilic Oesophagitis Outcomes Versus Placebo Regardless of Comorbidities or Treatment History in a Randomised Clinical Trial

BACKGROUND: Patients with eosinophilic oesophagitis (EoE) can present with differing disease characteristics, treatment resistance, and associated type 2 inflammatory comorbidities. We assessed the efficacy of dupilumab in subgroups of patients with EoE from the LIBERTY EoE TREET...

Neuropsychiatry genetics in Africa

Across Africa, rising mental health needs coincide with rapid advances in genomics, digital health and continental policy reform. Yet research into the genetic, environmental and social determinants of neuropsychiatric illness remains sparse and underfunded. This review argues th...

The Benjamini–Hochberg procedure can fail to control the FDR for correlated two-sided Gaussian tests

The Benjamini–Hochberg (BH) procedure is the standard method for controlling the false discovery rate (FDR) in large-scale studies involving testing multiple hypotheses. Whether the BH procedure controls the FDR for every correlation structure among two-sided Gaussian tests has b...

Detailed Analysis of Intraretinal Layers and Their Correlation to Brain Structures in Normal Healthy Aging

Purpose: The purpose of this study was to investigate the relationships between intraretinal layer volumes and visual cortical thickness in healthy individuals and determine the influence of age on these associations. Methods: Fifty-three subjects were recruited. One eye per subj...

Organizational Factors Impacting Implementation of Evidence-based Practices for Autistic Youth: A Mixed Methods Evaluation of Virginia’s Community Mental Health System

Abstract Despite elevated rates of co-occurring mental health needs among autistic youth, availability of and access to mental and behavioral health evidence-based practices (EBPs) remain limited in U.S. community-based settings. Further, community-based service systems are compl...

Anticancer Drugs and Cancer-Associated Thrombosis

The rapid development of novel cancer therapies has considerably improved the care of cancer patients and cancer-related survival; however, these therapies are associated with a broad range of adverse events that have become a major burden in this population. Alongside other canc...

Selective PET imaging of bacterial infection using a glycosylated 18F-fluorodeoxyglucose-derived tracer

Abstract Distinguishing bacterial infection from non-infectious inflammation remains challenging because most clinical imaging detects the host inflammatory response rather than the bacteria themselves. The widely used glucose analogue 18 F-fluorodeoxyglucose accumulates in metab...

Negative Chemotaxis of Urease‐Functionalized Polymeric Microcapsules

Enzyme-driven micromotors provide a promising platform for mimicking biological chemotaxis and for developing responsive materials. We recently developed a method to make cell-sized asymmetric urease-functionalized poly(lactic-co-glycolic acid) (PLGA) microcapsules that are highl...

Genetic Basis of Social Structure in the Pastoral Nomads of Central Eurasia

Abstract Although the social structure of Central Eurasian pastoral nomads has been described as fluid and ad hoc by historians and anthropologists, its potential genetic basis remains poorly understood. To evaluate whether kinship based social organization has biological foundat...

Before Water - A long poem

Read the poem inside and watch Bob Perelman reads it here. You may also watch an entire reading panel with Perelman, Craig Dworkin and Michael Golston held at Columbia University here.

Service-Level Utilization in Risk-Based Contracts and a Benchmarking Approach for Fee-Schedule Reforms

Importance Despite revived interest in reforming the physician fee schedule, it is unclear how policymakers should modify more than 1000 different physician service prices to promote high-value care. One systematic approach could leverage service-level utilization patterns in ful...

US Food and Drug Administration Officials’ Public Statements on Regulatory Flexibility in New Drug Approval, 2021–2024

The US Food and Drug Administration (FDA) has historically exercised substantial regulatory flexibility to adjust the type, amount, and quality of evidence necessary to support drug approval for areas of unmet need. Our objective was to characterize how FDA officials described an...

International Modified Delphi Consensus on Assessment and Management of Covert Brain Infarction

BackgroundCovert brain infarction (CBI) is a frequent incidental neuroradiological finding increasingly recognized as clinically relevant due to its association with stroke, cognitive decline, and other adverse outcomes. However, substantial uncertainty remains regarding its opti...

The Childhood Liver Disease Research Network's prospective characterization of pediatric primary sclerosing cholangitis.

BACKGROUND: Primary sclerosing cholangitis (PSC) is a rare biliary fibrosing disease that leads to significant morbidity and the need for liver transplantation. The Childhood Liver Disease Research Network is conducting a prospective, observational longitudinal study to define th...

Random Testing via Runtime Abstract Interpretation

Property-based testing of C programs can be automated by synthesizing random input generators from separation-logic specifications. Existing work in this space, such as the Bennet testing tool, uses randomized backtracking search, generating random values and checking them agains...

Evaluating the Reliability, Accuracy, and Readability of ChatGPT-3.5 and GPT-4 in Providing Patient Education Related to Glenohumeral Joint Osteoarthritis.

OBJECTIVES: Chatbots have been increasingly recognized as modern tools that provide patients with reliable health-related information. This study aimed to evaluate and compare ChatGPT-3.5 and GPT-4's ability to answer glenohumeral osteoarthritis-related questions. METHODS: Fiftee...

Assessing and Addressing Frailty in Candidates for Lung Transplantation: An ISHLT Consensus Statement.

The ISHLT Consensus document for the selection of lung transplant candidates recommends frailty assessment as part of a comprehensive candidacy evaluation. Missing from this and other recent consensus documents were practical recommendations on which frailty measures to consider...