University of Pennsylvania

Mechanics of electroadhesion by polycation interfacial bridging: sticky electrophoresis, ionic complexation and chain entanglement

Abstract An e-GLUE is a polymer network containing interpenetrating polycations, which can bond the anionic network of mucosa by polycation interfacial bridging under an electric field. This paper formulates a theoretical model to study such electroadhesion by electrophoresis of...

Health-related quality of life in patients with spinal muscular atrophy receiving nusinersen and their caregivers: a cross-sectional study

Spinal muscular atrophy (SMA) is a rare neuromuscular disorder characterized by progressive motor decline. Although nusinersen has improved survival and motor outcomes, patients and caregivers continue to face substantial medical and psychosocial challenges. As treatment goals ha...

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

BACKGROUND: Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin-6 (IL-6) inhibitor, is the only FDA-approved treatment for adult patients with iMCD. Limited...

Line-intensity mapping

Line-Intensity Mapping (LIM) has emerged as a powerful technique for studying large-scale structure and the high-redshift universe, enabling three-dimensional maps of line emission across vast cosmological volumes. In this review, we summarize the LIM framework, its key scientifi...

Response to Electroconvulsive Therapy in a Patient With SCN2A-Variant Catatonia Is Associated With Postictal Spreading Depolarization

An 18-year-old female patient with a history of autism spectrum disorder and SCN2A loss-of-function variant received a course of electroconvulsive therapy (ECT) for catatonia, which had been present and disabling for 1 year. After a partial lorazepam taper, bitemporal ECT was ini...

Blood proteomics of menopause map to brain aging and dementia risk

Abstract Menopause is a hallmark process in biological aging that has been implicated in later neurodegenerative risk, but the pathways underlying this connection remain unclear. Here we used blood proteomics data from several cohorts to identify biological changes associated wit...

Characterization of Large-Scale Mitochondrial DNA Rearrangements Using Complementary Short- and Long-Read Sequencing Approaches

Background: Large-scale mitochondrial DNA (mtDNA) rearrangement, including deletion or duplication, is one of the important causes of primary mitochondrial disease. In clinical practice, short-read sequencing (SRS)-based assays typically detect these rearrangements by identifying...

Oropouche virus disrupts neurodevelopment and exhibits congenital infection potential

Oropouche virus (OROV) historically caused a self-limiting disease, yet recent strains have been clinically linked to congenital infection and neurodevelopmental disease. These observations highlight the need to study OROV as a congenital pathogen. Here, using both a historical a...

Beyond Fixed Restriction Time: Adaptive Restricted Mean Survival Time Methods in Clinical Trials

Summary Restricted mean survival time offers a compelling nonparametric alternative to hazard ratios for right-censored time-to-event data, particularly when the proportional hazards assumption is violated. By capturing the total event-free time over a specified horizon, it provi...

Implementing Community-Based Model-Driven Decision Support to Reduce Overdose Deaths: Lessons Learned at Study Midpoint

The overdose crisis continues to be a critical public health challenge in the United States and elsewhere. While funding has been provided at the federal, state, and municipal levels, implementation of strategies to address overdose is accomplished at the county level in most sta...

Bioengineered microtissue model of the human nigrostriatal pathway featuring centimeter-scale axon tracts and structural maturation over 6 months in vitro

The basal ganglia (BG) comprise a critical neural system involved in voluntary motor coordination and balance. While small animal models have been useful to improve our basic understanding of the development and function of neural systems, they are relatively low-throughput, lack...

Ti3C2T x MXene-Enhanced Paper-Based Ion-Selective Electrodes for Sweat Sodium Monitoring

Abstract Electrolyte balance plays a fundamental role in maintaining physiological homeostasis, as ionic fluctuations regulate cellular excitability, osmotic gradients, and neuromuscular signaling. Among electrolytes, sodium (Na+) is a critical biomarker for hydration status and...

Conserved C-terminal residues adjacent to the canonical PDX1 homeodomain are required for chromatin occupancy and pancreas development

Essential roles for the PDX1 transcription factor in pancreatic development and β-cell function are well-known, yet the structure-function relationships of domains within its C-terminus remain incompletely defined. We identified a focal intrinsically disordered region (IDR) spann...

Women’s Attitudes toward the 2024 US Preventive Services Task Force Mammography Screening Guideline

Background: From 2009 to 2024, the US Preventive Services Task Force (USPSTF) recommended that women aged 40 to 49 y make an informed choice about when to begin having mammograms. In 2024, the USPSTF changed its guidelines, recommending biennial screening from age 40 to 74 y. Thi...

MELD-based allocation disproportionately prioritizes alcohol-associated hepatitis for liver transplant

Early liver transplantation (LT) is increasingly being adopted as a treatment for alcohol-associated hepatitis (AAH), but the optimal strategy for incorporating AAH into the existing organ allocation framework remains unclear. This retrospective cohort study used the United Netwo...

A miRNA-mediated gene regulatory network supports seasonal plasticity in the temperate coral Astrangia poculata

Phenotypic plasticity is critical for sessile marine invertebrates facing intensifying climate change. MicroRNAs (miRNAs)-small non-coding RNAs that regulate gene expression-are compelling candidates for mediating such plasticity, but their role in coral biology remains poorly ch...

Making the Case: Demonstrating the Value of Pediatric Hospital Medicine to Hospital Leadership

Pediatric hospital medicine (PHM) has become a foundational component of inpatient pediatric care; however, its value is frequently evaluated through a narrow financial lens. This C-suite series piece examines how PHM's contribution to 'value' encompasses not only professional re...

Clonal Hematopoiesis of Indeterminate Potential Proteomic Risk Score for Predicting Clinical Outcome in Patients With Heart Failure With Preserved Ejection Fraction

BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP) is common in heart failure with preserved ejection fraction (HFpEF). However, the proteomic signatures linked to CHIP driver mutations and their prognostic implications in HFpEF remain poorly defined. We aimed to...

A Mesoscopic Ginzburg–Landau Model for Vibrational Strong Coupling Enhanced Rayleigh Scattering in Molecular Liquids

Abstract Recent experiments by Sandeep et al. [Angew. Chem. Int. Ed.65, e16917 (2026). ] suggest that vibrational strong coupling (VSC) in molecular liquids can generate mesoscopic phenomena beyond single-molecule observables, including resonantly enhanced Rayleigh scattering, ab...

What Can a Badge Do? A Pilot Study of the Vot-ER Badge in a Community Health Setting

Civic engagement is an important example of health and health care inequity in the United States, with voting being an active form of civic engagement that allows citizens to be involved in the political processes that directly impact their health. Existing literature indicates t...