University of Pennsylvania

Pre-trained knowledge transfer with application in multisystem inflammatory syndrome subphenotyping in children

Multisystem inflammatory syndrome in children (MIS-C) is a severe post-acute sequela of SARS-CoV-2 infection in children and presents with highly heterogeneous signs and symptoms. Disentangling the clinical manifestations of MIS-C by characterizing its subphenotypes can help iden...

Long‐term prediction of epilepsy following traumatic brain injury among veterans using routine clinical data

OBJECTIVE: Despite elevated risk for epilepsy following traumatic brain injury (TBI), there are limited tools to assess epilepsy risk following TBI using routine clinical data. The objective of this study was to develop and validate a machine learning approach to predict the onse...

Beyond Digital Access: Domains and Breadths of Everyday Digital Technology Engagement and Associations with Cognition Among Older Adults

BACKGROUND AND OBJECTIVES: This study identified latent domains and usage-breadth patterns of everyday digital technology (EDT) engagement among older adults and examined their concurrent and prospective associations with cognition. RESEARCH DESIGN AND METHODS: The analytic sampl...

Gas-assisted electrodeposition modulates the grain structure of Cu catalysts for selective conversion of CO2 to C2+ products

Electrochemical CO 2 reduction has attracted considerable research interest as a pathway to convert CO 2 into value-added multicarbon products. Cu is a key catalyst for multicarbon-product formation, and its selectivity is strongly affected by its microstructure. However, the eff...

Epidemiology of Health-Related Social Needs Screening and Positivity in a Multistate Health System

Importance: Health systems increasingly screen for health-related social needs (HRSNs), which are modifiable social factors associated with health outcomes. However, screening selection biases and HRSN burdens are poorly characterized. Objective: To evaluate patient characteristi...

Distraction in anterior plagiocephaly: technique, risks, and long-term results

PURPOSE: The purpose of this study is to define the perioperative outcomes and long-term aesthetic outcomes of patients with unicoronal craniosynostosis (UCS) treated with fronto-orbital distraction osteogenesis (FODO) and compare them to a contemporaneous cohort treated with con...

Disparities in Medical Documentation for Pediatric Headache in the Emergency Department

OBJECTIVES: We examined associations between patients' socioeconomic and clinical factors and the thoroughness of clinical notes for children visiting the pediatric emergency department (ED) for headache. METHODS: This is a secondary analysis of data from a retrospective chart re...

Impact of magnification and fluorescence guidance on conservative retrieval of failed fiber posts: an in vitro study

Abstract Background Fiber post removal during endodontic retreatment is challenging since fiber posts bond strongly to root dentin, closely matching its color, making the post–cement–dentin interface difficult to distinguish. Consequently, fiber post retrieval may cause unnecessa...

Escaping the Plantationocene: plotting the future of education

Purpose This article critically analyses the ways in which contemporary international educational development perpetuates plantation systems. It proposes ways to plot an escape from the plantation's extractive education monoculture and move towards multi-epistemological flourishi...

Community Firearm Violence, Youth Depression, and Suicide Risk in Philadelphia: 2017–2024

OBJECTIVES: Youth suicide and depression rates increased during the COVID-19 pandemic. In Philadelphia, firearm violence surged and has since declined to pre-pandemic levels. We examined whether youth depression and suicide risk also declined and whether community firearm violenc...

Surgical Management of Young Women with High-Risk Breast Cancer Receiving Neoadjuvant Systemic Therapy on the I-SPY2 Trial

BACKGROUND: Mastectomy rates in women with breast cancer are higher in younger women than in older women. The impact of this more extensive surgery on overall survival (OS) and locoregional recurrence in younger women is unknown, especially after neoadjuvant systemic therapy (NST...

Exploring Middle and High School Personnel’s Definition and Knowledge of Evidence-Based Practices for Autistic Students

Background Mandates that educators use evidence-based practices (EBP) with autistic students have not led to their widespread or consistent implementation, despite their growing availability. EBP knowledge is integral to effective implementation, and prior studies have shown that...

A systematic review of environmental factors in AI-based fall risk prediction models for community-dwelling older adults

Falls commonly occur in home environments, where conditions can increase fall risk. Identification and mitigation of environmental hazards are critical components of fall prevention. However, artificial intelligence (AI)-based fall prediction models have largely focused on indivi...

Extended haplotypes at the complement factor H gene locus are associated with liver transplant rejection.

BACKGROUND: Acute T-cell-mediated rejection (ACR) remains an important complication after liver transplantation. Polymorphisms in the factor H gene (CFH) and factor H-related protein genes (CFHRs) affect the risk of multiple complement-related diseases. Given the complement syste...

Global Burden of Atopic Dermatitis: Examining Disease Prevalence Across Pediatric and Adult Populations World-Wide.

Atopic Dermatitis (AD) is a common, pruritic inflammatory skin disease associated with marked disease burden and substantial health care costs. AD does not discriminate between populations; prevalence estimates vary widely with most studies focusing on general or pediatric popula...

Icotrokinra (ICO), a Novel Targeted Oral Peptide, in Patients (Pts) with Psoriatic Disease: Exploratory Assessments from a Phase 2 Psoriasis (PsO) Study Informing a Phase 3 Clinical Program in Psoriatic Arthritis (PsA)

Objectives PsA affects ~20-30% of patients with PsO, causing articular inflammation and impaired quality of life. ICO, a novel targeted oral peptide that binds IL-23 receptor, showed greater clinical response rates vs placebo and a favorable safety profile in moderate-to-severe p...

Pharmaceutical Pricing and R&D as a Global Public Good.

This paper examines the international variation in the prices of branded pharmaceuticals. We consider short-run profits, or quasi-rents, as representing each country's contribution toward the global public good of therapeutic information embodied in new pharmaceuticals. We charac...

Structural Advantage and White Men's Health and Well-Being.

. 2026;116(8):1156-1164. https://doi.org/10.2105/AJPH.2026.308430).

A Randomized Hybrid Type I Effectiveness-Implementation Study of an eHealth Delivery Alternative for Cancer Genetic Testing for Hereditary Cancer (eREACH2): study protocol

Abstract Background Germline cancer genetic testing has become a standard evidence-based practice, with established risk reduction and cancer screening guidelines for genetic carriers. There are also targeted treatments for some genetic carriers with cancers such as breast and ov...