University of Pennsylvania

A novel, minimally invasive diagnostic test for KIT exon 11 internal tandem duplications in canine cutaneous mast cell tumours II: proof-of-principle applications

Abstract Background The clinical management of canine cutaneous mast cell tumour (cMCT) presents challenges. Treatment decisions are often informed by histopathological and molecular analysis of excisional biopsy samples, however, these may not always be available. Furthermore, c...

Distal humeral physeal separation: radiographic findings in infants and toddlers

Abstract Background Distal humeral physeal separation is an uncommon but frequently misdiagnosed injury of the immature elbow in infants and toddlers that carries a strong association with non-accidental trauma; its largely unossified anatomy makes radiographic diagnosis challeng...

Assessing residual bias in real-world vaccine effectiveness studies: validating negative controls to avoid misleading results

Observational studies and randomized controlled trials demonstrate that vaccines protect against infections and severe outcomes, but real-world vaccine effectiveness estimates remain vulnerable to residual biases. Negative control outcomes can help detect and mitigate such biases...

Immunotherapy-Related Cardiac Arrythmias: Incidence, Pathobiology, Risk Factors and Management

Abstract Purpose of Review Immunotherapies have revolutionized treatment strategies for cancer patients, improving the prognosis in many populations with advanced malignancies. Immune check point inhibitors (ICI) and Chimeric antigen receptor (CAR) T cell therapy are being increa...

Endoscopic Endonasal Transclival Approach to Pontine Cavernous Malformations in the Pediatric Population

BACKGROUND AND OBJECTIVES: Brainstem cavernous malformations (CMs) carry high hemorrhage risk and morbidity due to their eloquent location. Although modern microsurgical approaches emphasize safe entry zones, endoscopic endonasal transclival approaches (EETA) have emerged as a le...

Diagnostic Yield of Sequencing in Prenatal Agenesis of the Corpus Callosum in a Well‐Phenotyped International Cohort

ABSTRACT Objective To evaluate the incremental diagnostic yield of sequencing in a large, well‐phenotyped international cohort of fetuses with prenatally diagnosed agenesis of the corpus callosum (ACC) and to identify associated genes and variants. Methods Retrospective multicent...

Safety and Efficacy of Left Atrial Ablation After Percutaneous Left Atrial Appendage Occlusion in High-Bleeding-Risk Patients with Atrial Fibrillation: A Multicenter Analysis from the PROCEED-AF Ablation Registry

BACKGROUND AND AIMS: Patients with left atrial appendage (LAAO) devices are increasingly referred for AF ablation, yet anticoagulation strategies remain uncertain. The goal of this study was to evaluate the safety and efficacy of catheter ablation for atrial fibrillation (AF) in...

Phages Targeting Flagella: Adsorption and Infection Mechanisms of Flagellotropic Phages

Bacteriophages (phages) are viruses that exclusively infect bacteria. They adsorb to their hosts through binding to cell receptors including flagella, pili, or lipopolysaccharide (LPS). Adsorption is a two-step process, with reversible adhesion to cell surface receptors followed...

Cross-population genome-wide meta-analysis identifies pancreatic cancer susceptibility loci and etiologic pathways

Abstract Background Pancreatic cancer is a fatal malignancy influenced by genetic, metabolic, and lifestyle factors. We aimed to identify susceptibility loci and clarify associated genes, biological pathways, and potential etiologic factors. Methods We performed a cross-populatio...

Breast cancer therapy associated changes in thoracic aortic distensibility in those with or without hypertension (UPBEAT WF-97415)

Aortic stiffness or reduced distensibility may contribute to adverse cardiovascular events including myocardial infarction and stroke. This study assessed changes in thoracic ascending aortic distensibility (AAD) in breast cancer (BC) patients receiving potentially cardiotoxic ch...

ERVmancer: a phylogeny-guided framework for decoding human endogenous retrovirus regulatory mechanisms in health and disease

Human endogenous retroviruses (HERVs), remnants of ancient infections, comprise approximately 8% of the human genome and influence development, immunity, and cancer. Their repetitive sequences complicate short-read analysis because reads often cannot be assigned to individual loc...

Pathologic Characterization and Clinical Significance of Lymphovascular Invasion in Canine Thyroid Carcinomas

ABSTRACT The association between lymphovascular invasion (LVI) and outcomes in dogs with thyroid carcinoma is inadequately described, and a standardized definition of LVI is lacking. This study's objectives were to histopathologically and immunohistochemically characterize LVI an...

Increasing Utilization, Rising Facility Charges, and Evolving Procedure Mix in Hip Arthroscopy at United States Hospital‐Based Ambulatory Surgical Centers From 2016 to 2022

Purpose To evaluate national trends in hip arthroscopy utilization and procedure mix, assess adjusted total costs by subtype, and examine regional and payer variation in case distribution among hospital‐based ambulatory surgical centers (ASCs) from 2016 to 2022. Methods Using the...

Six-month mental health outcomes among participants in a postpartum care in the NICU (PeliCaN) trial: secondary analysis of a randomized controlled trial

Parents of infants admitted to the neonatal intensive care unit (NICU) face barriers to postpartum care and are at risk for adverse mental health outcomes. The Postpartum Care in the Neonatal Intensive Care Unit (PeliCaN) study evaluated a novel doula-coordinated, midwife-deliver...

Using Measurement-Based Care to Inform Antidepressant Medication Management Among Veterans: A Pilot Study

OBJECTIVE: This pilot study examined the effectiveness of high and low measurement-based care (MBC) feedback strategies for depression treatment. METHODS: Twenty providers at a U.S. Department of Veterans Affairs facility were randomly assigned to a no-feedback, low-feedback (aut...

Phase 1 Dose-Escalation Study of the Rapid-Clearance Radioligand [ 177 Lu]Lu-P17-087 in Metastatic Castration-Resistant Prostate Cancer: Dosimetry, Safety, and Preliminary Efficacy

Given the rapid systemic clearance and favorable kinetic profile of the novel DOTA(GA)2-conjugated ligand [177Lu]Lu-P17-087, this phase 1 study aimed to systematically evaluate the safety, pharmacokinetics, dosimetry, and preliminary antitumor activity of escalating therapeutic a...

2D theoretically twistable material database

The study of twisted two-dimensional (2D) materials, in which twisting layers create moiré superlattices, has created opportunities for investigating topological phases and strongly correlated physics. The broader potential of a seemingly infinite set of twistable 2D materials re...

Perceptions of Secure Messaging and Patient Safety: Results of an Interprofessional Survey

BACKGROUND AND OBJECTIVES: Communication technology within pediatric health care systems is rapidly evolving and has the potential to affect safety culture. After implementing a secure messaging communication platform at our quaternary care hospital, we aimed to evaluate the new...

Age-Associated Cognitive Deviations in Early-Onset Psychosis Patients and Their Siblings

OBJECTIVE: The objective of this study was to test for cognitive impairments and cross-sectional age-associated cognitive deviations in a large, diagnostically diverse, cross-sectional sample of children and adolescents with early-onset psychosis (EOP), their siblings, and nonpsy...

Temporal Dynamics of Urinary Extracellular Vesicle Excretion and Cargo in Healthy Subjects over 24 Hours

Abstract Urinary extracellular vesicles (uEVs) are promising non-invasive biomarkers of renal physiology and pathology, yet little is known about their temporal excretion patterns or optimal normalization strategies as urine concentrations vary significantly during the day. In th...