University of California, Los Angeles

Viscosity of NaAlSi3O8−H2O fluids and implications for arc magmatism

Water plays a crucial role in the transport properties of silicate liquids and is especially important in subduction-zone magma source regions where conditions promote complete miscibility between water and silicate melts. However, accurately tracing the movement of fluids and vo...

The future of high-dose, high-intensity neurorehabilitation: Consensus-based core recommendations from the fourth Stroke Recovery and Rehabilitation Roundtable

Objective: Convergent evidence indicates that high-dose, high-intensity rehabilitation (HDHI) improves outcomes beyond usual care after stroke, yet implementation remains limited. While questions of optimal dose, timing, and delivery format continue to be refined, the biological...

The clinical and molecular spectrum of AGO2-associated Lessel-Kreienkamp neurodevelopmental syndrome

Abstract Background Pathogenic variants in AGO2 ,encoding a central component of the RNA-induced silencing complex (RISC), cause the neurodevelopmental disorder Lessel-Kreienkamp syndrome (LESKRES). The variant spectrum and associated molecular mechanisms underlying phenotypic va...

Expert Perspectives on TGCT and the Outcomes of the Phase 3 MANEUVER Study of Pimicotinib Presented at ASCO and ESMO 2025: A Podcast Discussion

Tenosynovial giant cell tumor (TGCT) is a rare, locally aggressive neoplasm that significantly impacts patients’ quality of life through pain and swelling of the affected joint, resulting in limited range of motion. TGCT is categorized into two radiographic subtypes (localized an...

The filtration performance of fabrics against particles of viral size: a systematic review

Wearing a mask is part of the comprehensive strategy to suppress transmission of the SARS-CoV-2 virus and respiratory tract infections. Despite available COVID-19 vaccines, wearing a mask has remained one of the simplest and most effective ways. There was, however, little data av...

Development and Reliability Testing of the Sinonasal Assessment of Reepithelialization, a Novel Wound Healing Scale to Assess Postoperative Healing

ABSTRACT Background Sinus and skull base surgery create areas of demucosalized bone and cartilage in the sinonasal cavity, yet no standardized system exists to describe the progressive healing of these wounds. The goal of this study was to develop the novel Sinonasal Assessment o...

Characterising caregivers’ contingent responses: Short, slow, and clear speech facilitates infant turn-taking

Bidirectional temporal contingency in infant-caregiver interaction is believed to be instrumental in shaping the development of turn-taking and speech. Likewise, caregivers are known to modulate their voices in a distinctive register when speaking to infants. Yet, less is known a...

Thermal bottlenecks constrain early-life survival of native fish in regulated rivers

Climate change is reshaping thermal regimes worldwide, threatening species whose early development depends on narrow temperature ranges. Yet directly linking warming to reproductive failure in wild populations remains intractable, particularly in aquatic ecosystems. We developed...

Strategic design of methane observation networks to improve emission estimates: A case study in Africa

Abstract. Ground-based and satellite atmospheric observations are essential for reducing uncertainties in methane (CH4) emissions by atmospheric inversion, particularly in data-sparse regions such as Africa. However, adding new observation sites does not yield linear improvements...

Comparative Analysis of Ion and Electron Contributions to Ionospheric Ionization at Auroral and Subauroral Latitudes

Abstract Electron and proton precipitation into the nightside ionosphere is a key process in magnetosphere–ionosphere coupling. Although auroral electron precipitation at –10 keV is traditionally considered the main driver of auroral emissions, recent studies show that keV electr...

Acromial Stress Fractures in Reverse Total Shoulder Arthroplasty: Diagnosis, Prevention, and Treatment

PURPOSE OF REVIEW: This review critically evaluates the literature on acromial stress fractures (ASFs) following reverse total shoulder arthroplasty (rTSA), with a focus on risk factors, prevention, and treatment. By synthesizing contemporary evidence and highlighting areas of on...

A biobank-scale method for learning modulators of gene-environment interaction underlying human complex traits from multiple environmental exposures

Abstract It is increasingly recognized that genetic effects on complex traits and diseases are shaped by environmental context. Biobanks that measure diverse environmental exposures alongside genotypes and phenotypes at scale enable systematic study of gene-environment (G×E) inte...

An ex vivo gut mucosal explant assay to compare HIV tissue susceptibility shows increased HIV susceptibility with methamphetamine exposure

Background: mucosal explant models for HIV assess viral replication but do not fully capture the ability of tissue to support productive infection and transfer to target cells, an important indicator of tissue susceptibility. Additional tools to investigate relative mucosal susce...

Association between exposure to air pollution and age at natural menopause: The Study of Women's Health Across the Nation.

CONTEXT: Air pollution is a recognized risk factor for women's subfertility, yet its association with the timing of natural menopause remains understudied. OBJECTIVES: To examine the association between exposure to ambient air pollution and age at natural menopause (ANM). DESIGN...

Topographic analysis of choroidal thickness in pachychoroid disease using ultra-widefield swept-source optical coherence tomography

Purpose To characterise regional and topographic choroidal thickness (CT) profiles using ultra-widefield swept-source optical coherence tomography (UWF SS-OCT) and to compare topographic CT between normal eyes and eyes with pachychoroid disease. Methods All participants underwent...

Simulating exciton transport with complex absorbing potentials

We introduce a stochastic framework based on complex absorbing potentials (CAPs) to investigate exciton transport in large molecular aggregates. Within this framework, CAPs act as non-Hermitian reservoirs and sinks, enabling an effective assessment of transport efficiency. We app...

Ancestry and Kawasaki Disease: Clinical Pathway Considerations

Kawasaki disease (KD) is the leading cause of pediatric acquired heart disease in developed countries.1 Despite decades of research, no established biologic marker has been identified, and KD remains a clinical diagnosis.1,2 However, KD research has shown that different populatio...

Changes in Emergency Department Pediatric Readiness, Inpatient Services, and Excess Child Deaths

Importance Emergency department (ED) pediatric readiness and pediatric inpatient services have changed over time in many hospitals, but the impact of these changes on pediatric outcomes is unclear. Objective To evaluate pediatric mortality associated with changes to ED pediatric...

Game Developments [Simulation and Convergence Scenarios]

There are tools to fastly simulate the Universe in Diverse Scenarios : among those tools, are mainly the Game Development tools. We will introduce few notes about them.

RobustCell: a model attack-defense framework for robust transcriptomic data analysis

Abstract Computational methods should be accurate and robust for tasks in biology and medicine, especially when facing different types of attacks, defined as perturbations of benign data that can cause a significant drop in method performance. Therefore, there is a need for robus...