University College London

COFAS Grade is not Associated with Outcomes following Infinity Total Ankle Arthroplasty: A Multicenter Study with Minimum Five-Year Follow-Up

Background: Total ankle arthroplasty (TAA) is increasingly used for end-stage ankle arthritis, with modern fixed-bearing designs demonstrating improved survivorship. The Canadian Orthopaedic Foot and Ankle Society (COFAS) classification stratifies patients by intra-articular and...

Non-isothermal vertical distribution functions for the Milky Way

Abstract The vertical structure of our Galaxy has commonly been assumed to follow a pseudo-isothermal distribution. However, there is no a priori reason to expect this form to arise from scattering by giant molecular clouds (GMCs), since GMCs are confined to a narrow layer around...

Year-Round High-Resolution Sea Ice Freeboard Retrieval Using ICESat-2 ATL03 Photon Data

Abstract. Arctic sea ice freeboard is critical for estimating ice thickness and characterizing surface morphology, yet it remains poorly constrained, especially during the melt season due to limitations in conventional altimetry products. The ICESat-2 ATL07 product retrieves surf...

Modeling of Diamond Trench Metal Oxide Semiconductor Barrier Schottky Rectifier Based on Dynamic Reverse Bias Simulation Framework

This work presents an electrothermal optimization study of diamond‐based trench metal oxide semiconductor (MOS) barrier Schottky (TMBS) rectifiers using mixed‐mode drift‐diffusion technology computer aided design simulations under quasi‐static and dynamic reverse‐bias conditions....

Practical tools for using evidence of mechanisms to establish correlations

Abstract. Evidential pluralism is the view according to which we need to think about varieties of evidence. Specifically, to establish causal claims (in medicine and elsewhere), we need evidence of correlation and evidence of mechanisms. The publication of Parkkinen (2018) marked...

The Molecular Footprint of Thrombosis: What Does Myocardial Platelet Imaging After STEMI Tell Us?

Heerajnarain Bulluck, MBBS PhD, Derek J Hausenloy, MBChB PhD; The Molecular Footprint of Thrombosis: What Does Myocardial Platelet Imaging After STEMI Tell

Gene Silencer Therapy in Transthyretin Amyloid Cardiomyopathy

Importance: Gene-silencing therapies reduce hepatic transthyretin (TTR) production and have been evaluated in phase 3 trials in TTR amyloid cardiomyopathy (ATTR-CM). However, differences in trial design and background therapies have limited assessment of the overall treatment eff...

Correlated Polymer‐Proton Hopping Enables Water‐Independent Fast Proton Transport in Poly(Ionic Liquid) Membranes

Polymer electrolyte membranes composed of ionic liquids (IL), capable of conducting protons efficiently at elevated temperatures, without external humidification, could transform fuel cell technology. However, the molecular origins of such proton transport remain poorly understoo...

Immune control of HIV viraemia in early paediatric infection is associated with induction of HIV-specific CD8+ T-cell activity following multiple treatment interruptions

BACKGROUND: Virus-specific CD8+ T-cells play an important part in HIV cure/remission in adults, yet their role in paediatric immune control is limited by tolerogenic early-life immunity. Very-early ART initiation, while effective in restricting viral reservoir size, also prevents...

Autism and attention-deficit/hyperactivity disorder traits as predictors of tic phenomenology in children and adolescents

Abstract The co-existence of autism and attention deficit/hyperactivity disorder in tic disorders is a key factor influencing clinical decision-making. Given the shared clinical features and a potentially overlapping aetiology, the need to identify specific tic characteristics as...

Classifications of Substorms With MLT Patterns of SMU‐SML Indices Based on Convection Properties

Abstract During substorms, magnetospheric convection and magnetotail current sheet disturbances are two critical processes, both driving ionospheric electrojets. Dusk‐side SMU and dawn‐side SML (SuperMAG Electrojet indices) enhancements reflect two‐cell convection. Using this rel...

Vitamin C-Incorporated Polycaprolactone Membranes Enhance Angiogenic–Osteogenic Coupling by Modulating Oxidative Stress In Vitro

The study investigates the influence of vitamin C-incorporated polycaprolactone (PCL-Vit C) membrane in scavenging reactive oxygen species (ROS) and enhancing angiogenic–osteogenic coupling in vitro. Human umbilical vein endothelial cells and human fetal osteoblast cells were co-...

Pharmacological Inhibition of Small Extracellular Vesicle Secretion by ALK5i SD‐208 via Lysosomal Rerouting of CD63+ Compartments

ABSTRACT Pharmacological tools to selectively modulate extracellular vesicle (EV) secretion are scarce. Here, we identify the ALK5 (TGF‐β receptor I) inhibitor SD‐208 as a potent suppressor of small EV (sEV) secretion that acts independently of its canonical anti‐fibrotic activit...

Multimodal fusion of complementary material representations for generalizable and interpretable property prediction

Material properties often depend on coupled compositional, structural, and geometric factors that are incompletely captured by any single representation. We introduce interpretable multimodal fusion (IM-Fuse), a framework that integrates compositional descriptors, crystal graphs,...

Driven to succeed? Teenagers’ achievement motivation, university aspirations, and performance on high-stakes examinations

Abstract There is growing interest in how young people’s socio-emotional skills, particularly motivation, shape educational outcomes. Yet less is known about how adolescents’ general achievement motivation and their specific aspirations to attend university relate to performance...

Effect of Aficamten on Cardiac Structure and Function in Patients with Symptomatic Nonobstructive Hypertrophic Cardiomyopathy

BACKGROUND: Aficamten significantly improved both functional capacity and patient-reported health status in patients with symptomatic nonobstructive hypertrophic cardiomyopathy in the phase 3 randomized, placebo-controlled ACACIA-HCM trial (Assessment Comparing Aficamten to Place...

High-grade serous ovarian cancer is associated with increased TP53 mutation burden in uterine lavage

High grade serous ovarian cancer (HGSC) has low survival partly due to the lack of methods for detection, diagnosis, and risk prediction. TP53 mutations, which drive HGSC, are found in gynecological tissues as the result of somatic evolution, but it is unknown whether an excess o...

Archeological theory and AI: the potential past through agentic systems

Abstract The increasing capabilities of AI in automation and integration within existing methodology present a new opportunity for disciplines to address long-standing theoretical challenges. This is evident in archaeology, where persistent theoretical debates and interpretive va...

National multi-specialty robotic surgery training curriculum and implementation for UK surgical residents: a delphi consensus

Abstract Robotic-assisted surgery is now established across multiple surgical specialties in the United Kingdom, yet training for surgical residents remains variable, resource-dependent, and insufficiently standardised at national level. This study sought multispecialty expert co...

Are Group Interventions Effective at Improving Health Outcomes in Culturally And Linguistically Diverse (CALD) Populations With Chronic Conditions? An Umbrella Review

Abstract Culturally and linguistically diverse (CALD) populations experience disproportionate burdens of chronic disease compared to the general population; previous research demonstrated group-based interventions improve health outcomes across various chronic conditions. This um...