University College London

Diagnosis and management of transthyretin amyloidosis (ATTRv) across ATTRv-PN and mixed phenotype: an international delphi consensus

Abstract Background Transthyretin amyloidosis is a progressive, potentially fatal genetic disorder primarily associated with polyneuropathy (ATTRv-PN) or cardiomyopathy (ATTR-CM). Disease presentation is heterogenous. Patients often present with a mixed phenotype. Although recent...

Predicting Core-Level X-ray Photoemission Spectra of Oxide Surfaces from First-Principles─A Case Study for SnO2

Abstract X-ray photoemission spectroscopy (XPS) is a powerful technique to gain insight into the chemical properties of oxide surfaces. However, the interpretation of XPS spectra is notoriously difficult as realistic surfaces contain different terminations, reconstructions, adsor...

CTPA-detected coronary artery calcification as a prognostic marker in acute pulmonary embolism: a narrative review

Abstract Background Acute pulmonary embolism (PE) is a major cause of cardiovascular morbidity and mortality. Coronary artery calcification (CAC) is often visible on routine contrast-enhanced, non-ECG-gated CT pulmonary angiography (CTPA), offering potential refinement of risk as...

Are UK Research Priorities Aligned? Comparing the Research Priorities of the Down Syndrome, Fragile X Syndrome and Williams Syndrome Communities, With the Research and Funding Landscape

ABSTRACT There is a lack of understanding of how research activity in learning disability compares with community research priorities in the United Kingdom, where an estimated 1.5 million people live with a learning disability. Using Down syndrome (DS), Fragile X syndrome (FXS) a...

Nutritional intake on dialysis and non-dialysis days and the effect of intradialytic food provision among hemodialysis patients, a single-center study

Abstract Background/Objectives Patients receiving hemodialysis (HD) are at risk of malnutrition due to the considerable time required to attend dialysis, which may reduce food intake on dialysis days (DDs). We assessed dietary intake on one DD and two non-dialysis days (NDDs) and...

Disability inclusion for just transitions: A semi-systematic review of representations of persons with disabilities in energy transition research

Transitions to low-carbon energy systems risk perpetuating existing social inequalities if they fail to account for marginalised groups. Persons with disabilities are often overlooked in energy policy and research, despite having distinct and often greater energy needs, requiring...

Land use and climate warming interact to reshape global avian biodiversity through ecological filtering and homogenisation

Land-use and climate change are dominant drivers of terrestrial biodiversity change, yet are usually analysed separately although they co-occur and may interact. We integrated global bird assemblage records from PREDICTS with temperature anomalies and species' ecological characte...

Non-sewered sanitation systems reshape microplastics into chemically complex and reactive contaminants

Non-sewered sanitation systems (NSSSs) are gaining global attention as decentralized solutions, yet the transformation of microplastics (MPs) within these systems remains poorly understood. Here, we investigate MP characteristics in the influent and effluent of two NSSSs using la...

Distilling First-Principles Accuracy into Compact Machine Learning Potentials for Condensed-Phase Chemistry

Abstract Accurate machine learning interatomic potentials (MLIPs) have made first-principles-quality potential energy surfaces increasingly accessible for condensed-phase chemistry, but their inference cost can still limit the sampling needed to compute experimentally relevant ob...

Child health service coverage estimation using routine health data from Ghana’s Eastern Region

Abstract Background Suboptimal resource allocation limits uptake of essential health services in sub-Saharan Africa. Reliable population denominators and coverage estimates are needed to better match health facility resources to local demand. An estimation approach utilising rout...

How does explicit reliability guide choices? Effect of trustworthiness on choice and metacognition

A key challenge in today’s fast-paced digital world is to integrate information from various sources, which differ in their reliability. Yet, little is known about how explicit probabilistic information about the likelihood that a source provides correct information is used in de...

Protocol for genome-wide differential methylation using long-read DNA sequencing in the cortex of a mouse model of Alzheimer’s disease

Third-generation sequencing enables direct detection of genome-wide 5-methylcytosine without bisulfite conversion. Here, we present a protocol for generating long-read DNA sequencing from mouse cortex and performing genome-wide differential methylation analysis. We describe steps...

Where in the Prenatal Screening Pathway do Ethnic and Socioeconomic Inequalities Occur? A UK Retrospective Cohort Study

ABSTRACT Objective To examine if and where ethnic and socioeconomic inequalities arise within the English NHS prenatal screening pathway by investigating associations between ethnicity, socioeconomic deprivation, screening test type, further testing uptake, and pregnancy outcomes...

Service-level and practitioner-level recommendations for better care of people with dementia who live alone and have no informal caregivers

Context A substantial proportion of people with dementia live alone without informal caregivers, yet services often assume family involvement, increasing risks of unmet need and adverse outcomes. Objective This study aimed to generate service-level and practitioner-level recommen...

Health system and household costs of preventive treatment delivery for children exposed to multidrug-resistant tuberculosis in South Africa

Background Tuberculosis (TB) preventive treatment (TPT) is a core component of TB control. Levofloxacin was recently recommended by the World Health Organization as TPT in children exposed to multidrug-resistant tuberculosis (MDR-TB). However, the affordability and feasibility of...

Employee Creativity in Project-Based Organizations: Inhibited or Promoted by Organizational Controls?

Creativity and control are both vital to creative project-based organizations: The former enables innovation, adaptability, and problem-solving in uncertain or novel conditions, whereas the latter ensures alignment, stability, and goal-directed execution within constraints. Never...

State-Constrained SHAP Distills Polymer Property Models into Transferable Structural Rules for Fixed-Interval Screening

Abstract Polymer informatics has accelerated data-driven prediction of polymer properties, yet accurate prediction does not directly enable discovery. Here, we introduce state-constrained SHAP (SC-SHAP), an attribution-to-rule distillation framework for fixed-interval polymer scr...

Marfan Syndrome versus Loeys–Dietz Syndrome after Aortic Surgery: A Systematic Review and Meta-analysis of Reconstructed Time-to-Event Data

Abstract Marfan syndrome (MFS) and Loeys–Dietz syndrome (LDS) are hereditary connective tissue diseases, both characterized by aortic root and vessel involvement with an increased risk of aneurysms and dissections. Despite advances in surgical techniques and improved postoperativ...

Meeting young people where they are – digital adaptations of CBT for psychosis: a real-world approach

Purpose Young people experiencing psychosis frequently disengage from traditional psychological therapies, while their routine use of digital technologies offers new opportunities to improve engagement, accessibility and continuity of care. This practitioner article aims to descr...

Brief internet intervention for grieving children and adolescents: co-design and trial protocol

ISRCTN.org identifier: ISRCTN21132251.