University College London

Delivering building demand flexibility for grid-interactive operation: from perception and cognition to decision, execution, and verification

As both buildings and power systems undergo rapid decarbonization, demand flexibility (DF) in buildings has emerged as a key enabler for renewable energy integration, grid reliability, energy resilience, and efficient and low carbon operation. By dynamically adjusting building en...

Teaching Signal Synchronization in Deep Neural Networks with Prospective Neurons

Abstract Working memory requires the brain to maintain information from the recent past to guide ongoing behavior. Neurons can contribute to this capacity by slowly integrating their inputs over time, creating persistent activity that outlasts the original stimulus. However, when...

PLCG2 downregulation impairs synaptic function and increases Alzheimer’s disease hallmarks in neuronal cultures

We developed a high-content screening to investigate how Alzheimer’s disease (AD) genetic risk factors may affect synaptic mechanisms in rat primary neuronal cultures. Of the target genes identified, we found that Plcg2 downregulation in mouse dentate gyrus neurons consistently d...

Multilayer networks in finance: a systematic review

<title>Abstract</title> Stress in the global financial system propagates through multiple channels, including interbank credit and funding, overlapping portfolios, and bank–firm exposures. Multilayer networks represent these channels as interdependent layers, enabling analysis of...

Spatial qubit entanglement witness for quantum natured gravity

Abstract Witnessing the quantum nature of gravity through the entanglement of two masses has recently been proposed. Both non-Gaussian and Gaussian protocols have been shown to be useful for this purpose. In non-Gaussian protocols the complete 1/r gravitational interaction can in...

Eating Disorder Focused Family Therapy with Autistic Children and Young People: A Narrative Review of Recent Developments

Abstract Purpose of review This review aims to report the recent advances for eating disorder focused family therapy (FT-ED) for Autistic children and young people, including outcomes, experiences, and suggested adaptations. Recent findings Quantitative studies suggest that Autis...

Restriction of access to means of suicide in veterinary workplaces: Protection, unintended consequences and complexity

BACKGROUND: Workplace access to means of suicide has been theorised as a contributor to elevated veterinary suicide rates. Workplace interventions to reduce suicide deaths among veterinary professionals require understanding of how restriction of access is experienced. METHODS: Q...

Early Hospital Practices Were Associated With Exclusive Breastfeeding Among Late Preterm and Early Term Infants

AIM: To assess how maternal/infant characteristics and early hospital practices influenced exclusive breastfeeding at 2-3 weeks postpartum among mothers intending to breastfeed their late preterm and early term infants. METHODS: This secondary analysis used data from a randomised...

Twenty years of inhaler therapy: A nationwide drug utilization study

AIMS: This study aimed to map nationwide trends and prescribing patterns in inhaler use from 2004 to 2023. In light of evolving clinical guidelines and attention to the environmental impact of inhalers within recent years, we also examined variation in prescribing behaviour and p...

PHOS-UK: Open-source user interface for power-hydrogen-heat optimisation for the United Kingdom

This paper introduces PHOS-UK, an open-source graphical user interface (GUI) and optimisation-based decision-support tool for optimal planning of integrated energy infrastructure in the United Kingdom (UK), including electricity, hydrogen, heating, and CO 2 infrastructures. PHOS-...

Modeling driver cognitive states for shared-control vehicles in intelligent transportation systems

This study aims to model driver cognitive states for shared-control vehicles operating within intelligent transportation systems. We introduce driving activity level as an interpretable state variable that combines attention allocation, steering behavior, and perceived situationa...

Distribution of device-measured 24-hour movement behaviours across the cognitive spectrum in older adults: the HUNT study

Abstract Background Key daily physical activities (e.g., standing and walking), postures (sitting and lying), and sleep constitute the 24-h day and have distinct health effects and functional implications. Traditionally studied separately, the distribution of these movement behav...

Thromboxane A2-Driven Vascular Hyperreactivity in Cadmium-Induced Hypertension: Role of Oxidative Stress and Therapeutic Implications

Background/Objectives: Environmental factors, including heavy metals such as cadmium, are increasingly recognized as important contributors to hypertension beyond traditional risk factors. To date, the role of angiotensin and alpha-adrenergic receptors in hypertension induced by...

Spatially Explicit Optimal Decarbonization Pathways for China’s Cement Industry

Abstract Cement production contributes about 8% of global CO2 emissions, but conventional assessments often overlook spatiotemporal heterogeneity in demand, energy resources, infrastructure, and policy constraints. This study develops a high-resolution whole-system optimization f...

COPI Coatomer Regulates Several Steps of HDL Metabolism

Abstract Background Reverse cholesterol transport by high density lipoproteins (HDL) is considered as an anti-atherogenic metabolic pathway. Hepatocytes determine the efficacy of this pathway by the production of apolipoprotein A-I (apoA-I) and its lipidation by ATP binding casse...

Developing a scalable pipeline for data extraction from clinical letters through resource-efficient prompt engineering

<title>Abstract</title> Free-text clinical records represent an untapped wealth of data for secondary use. Their potential is limited by resource demands necessary for accurate information extraction at scale. We introduce a scalable, resource-efficient, and high-performance pipe...

Deep generative model for human mobility behavior

Understanding and modeling human mobility is central to challenges in transport planning, sustainable urban design, and public health. Despite decades of effort, simulating individual mobility remains challenging because of its complex, context-dependent, and exploratory nature....

Element-Specific DonorNumbers for Anions

Abstract Anion interactions with cations/molecules are crucial across chemistry and biology: in battery electrolytes, synthesis, atmospheric processes, and protein denaturation. Selecting the optimum anion represents an immense challenge, as anion interactions are diverse and com...

Genetic clusters of BMI reveal symptom-specific causal effects on depression

Abstract While BMI is phenotypically and genetically associated with depression, the extent to which BMI causes depression and the mechanisms underlying this effect remain unclear. We estimated the causal effect of BMI on depression symptoms, accounting for complexity in both the...

Fostering reflection: Development and initial evaluation of a mentalization-based GenAI simulator for foster care supervisors

Background Foster care supervisors require advanced reflective functioning (RF) to manage complex relational demands, yet traditional training is difficult to scale and access. Generative AI (GenAI) may help by enabling simulated practice environments. Objective This feasibility...