University College London

Classifications of Substorms With MLT Patterns of SMU‐SML Indices Based on Convection Properties

Abstract During substorms, magnetospheric convection and magnetotail current sheet disturbances are two critical processes, both driving ionospheric electrojets. Dusk‐side SMU and dawn‐side SML (SuperMAG Electrojet indices) enhancements reflect two‐cell convection. Using this rel...

National multi-specialty robotic surgery training curriculum and implementation for UK surgical residents: a delphi consensus

Abstract Robotic-assisted surgery is now established across multiple surgical specialties in the United Kingdom, yet training for surgical residents remains variable, resource-dependent, and insufficiently standardised at national level. This study sought multispecialty expert co...

High-grade serous ovarian cancer is associated with increased TP53 mutation burden in uterine lavage

High grade serous ovarian cancer (HGSC) has low survival partly due to the lack of methods for detection, diagnosis, and risk prediction. TP53 mutations, which drive HGSC, are found in gynecological tissues as the result of somatic evolution, but it is unknown whether an excess o...

Immune control of HIV viraemia in early paediatric infection is associated with induction of HIV-specific CD8+ T-cell activity following multiple treatment interruptions

BACKGROUND: Virus-specific CD8+ T-cells play an important part in HIV cure/remission in adults, yet their role in paediatric immune control is limited by tolerogenic early-life immunity. Very-early ART initiation, while effective in restricting viral reservoir size, also prevents...

Correlated Polymer‐Proton Hopping Enables Water‐Independent Fast Proton Transport in Poly(Ionic Liquid) Membranes

Polymer electrolyte membranes composed of ionic liquids (IL), capable of conducting protons efficiently at elevated temperatures, without external humidification, could transform fuel cell technology. However, the molecular origins of such proton transport remain poorly understoo...

Driven to succeed? Teenagers’ achievement motivation, university aspirations, and performance on high-stakes examinations

Abstract There is growing interest in how young people’s socio-emotional skills, particularly motivation, shape educational outcomes. Yet less is known about how adolescents’ general achievement motivation and their specific aspirations to attend university relate to performance...

Pharmacological Inhibition of Small Extracellular Vesicle Secretion by ALK5i SD‐208 via Lysosomal Rerouting of CD63+ Compartments

ABSTRACT Pharmacological tools to selectively modulate extracellular vesicle (EV) secretion are scarce. Here, we identify the ALK5 (TGF‐β receptor I) inhibitor SD‐208 as a potent suppressor of small EV (sEV) secretion that acts independently of its canonical anti‐fibrotic activit...

Global Efficacy of Aficamten in Nonobstructive Hypertrophic Cardiomyopathy: Results From ACACIA-HCM

BACKGROUND: Nonobstructive hypertrophic cardiomyopathy (nHCM) is associated with significant morbidity with no approved treatment. Aficamten is a cardiac myosin inhibitor targeting excess contractility and diastolic impairment, the predominant mechanism responsible for adverse ou...

When habit prevails: a causal test of policy feedback theory using a pension reform

Abstract Elderly voters are a growing, politically powerful electoral bloc, and their pensions often constitute the largest component of welfare state. We know that cuts can provoke electoral backlash, but it is less clear whether benefit expansions mobilize retirees. Some policy...

Social robots and future crime: a scoping literature review

Abstract Purpose Social robots are set to permeate every area of our lives from childhood, well into our old age—from education, policing, and entertainment, to healthcare. Ensuring that their deployment happens in a safe and secure way requires a firm understanding of the broad...

Aficamten for Symptomatic Nonobstructive Hypertrophic Cardiomyopathy

BACKGROUND: Nonobstructive hypertrophic cardiomyopathy (HCM) is a common condition that is associated with substantial morbidity and no proven medical therapy. Whether treatment with aficamten, a cardiac myosin inhibitor, can benefit patients with this condition is unknown. METHO...

Minimally verbal status in children with intellectual disability of genetic origin – prevalence, functional impact and relationship with motor skills: evidence from the IMAGINE-ID cohort

Abstract Background Up to a third of autistic children do not develop functional speech and remain minimally verbal (MV) beyond the age of 5, yet little is known about the clinical characteristics of this group. Less still is known about the prevalence or impact of MV status in c...

Inferential planning in the frontal cortex

Abstract How the brain plans and maintains sequences of future actions remains a central question in systems neuroscience. Recent studies in the frontal cortex have revealed that multiple elements of a sequence are represented simultaneously in separable neural subspaces, challen...

Tail Dependence: The Impact of Risk Spillovers on Real Estate Markets in Times of Economic and Geo‐Political Uncertainty

ABSTRACT The first half of the 2020's has seen a degree of economic and geo‐political uncertainty not observed since the 1970s. This paper looks at how listed real estate is exposed to capital market shocks by estimating Conditional Value‐at‐Risk (CoVaR), which captures the sensi...

The Psychoses : Jacques Lacan’s Seminar III (1955–1956)

SUMMARY During the academic year 1955–1956, Jacques Lacan, a prominent psychiatrist and psychoanalyst, delivered his third seminar in Paris. Seventy years later it remains little known among psychiatrists in the UK. Seminar III was devoted to the psychoses, particularly the delus...

Spin-disc misalignment drives periodic accretion and pulse profile asymmetry in X-ray pulsars

Abstract We investigate magnetospheric accretion in disc-fed X-ray pulsars assuming that the neutron star spin axis is not perpendicular to the disc plane. We focus on X-ray pulsars, where a geometrically thin disc is truncated far from the stellar surface the channelled part of...

Prevalence of Mental Disorders in Parents With Intellectual Disabilities: A Systematic Review

ABSTRACT Background Research indicates that an increasing number of adults with intellectual disabilities (IDs) are becoming parents. Parents with ID face multiple challenges that increase their mental health risks. In order to ensure better detection and tailored care for parent...

From six to twelve months: how extending the statutory prognostic threshold affected fast‑tracked end-of-life benefit access in England and Wales

Abstract Background To evaluate the impact of the 2022 change in prognostic eligibility criteria for the Special Rules for End of Life (SREL) pathway, from an expected death within 6 months to within 12 months, on the number and characteristics of awardees for fast-tracked financ...

Politicians on board! does foreign ownership matter for corporate political activity?

Purpose The nexus between firms and political actors is increasingly complex, particularly for foreign-owned firms operating in host countries. While corporate political connections can provide local knowledge and legitimacy, potentially transforming foreign-owned firms from “out...

Functional Stability Measured by Changes in the 6-min Walk Test in Patients Treated with Tafamidis Versus Placebo: Post hoc Analysis from ATTR-ACT

Tafamidis, a transthyretin stabilizer for the treatment of transthyretin amyloid cardiomyopathy (ATTR-CM), significantly reduced the decline in 6-min walk test (6MWT) distance, a marker of functional stability, compared with placebo in the pivotal study ATTR-ACT. In this post hoc...