University College London

A nutrient-sensitive CPT1C-ABHD6 axis regulates BMP homeostasis and endolysosomal function in hypothalamic neurons

The endolysosomal system is central to neuronal homeostasis, yet how nutrient sensing regulates endolysosomal lipids remains poorly understood. Bis(monoacylglycero)phosphate (BMP), a signature phospholipid of late endosomes, is required for intraluminal vesicle formation, cholest...

The Impact of Heterogeneity in Individual Characteristics and Motivation to Quit Heroin Use on Contingency Management and Opioid Agonist Treatment Response: A Latent Class Analysis

ABSTRACT Introduction Contingency Management (CM) involves the systematic application of positive reinforcement (financial incentives) to promote behaviour change, to improve treatment outcomes for individuals with opioid use disorder (OUD). To better understand patient heterogen...

The Composite Spectrum of QSO Absorption Line Systems in DESI DR2

Abstract We present details regarding a composite spectrum of quasar (QSO) absorption line systems. In this composite spectrum, we identify more than 70 absorption lines and observe oxygen and hydrogen emission features at a higher signal-to-noise ratio than any previous study. A...

Willingness to Participate in HIV Cure Research Among Young People Living with Perinatally Acquired HIV in the Centre Region of Cameroon: A Cross-Sectional Survey

Young people living with perinatally acquired HIV (YPLHIV) represent a unique population for HIV cure research, offering opportunities to assess interventions in a group for whom adherence to antiretroviral treatment (ART) is particularly challenging. Understanding their perspect...

Executive functions as a transdiagnostic endophenotype in developmental psychopathology

Abstract The majority of mental health conditions emerges before adulthood, with prevalence increasing especially during childhood and adolescence. Coupled with high comorbidity between disorders, there is an urgent need to identify transdiagnostic mechanisms that underpin both r...

Analysis of immediate upstream gene regions in orthopoxvirus genomes through the use of DNA Duplex Stability and explainable machine learning

Orthopoxviruses are double-stranded DNA viruses with a temporally regulated gene expression program divided into early, intermediate, and late stages. Although many temporal gene functions are known, the promoter features that distinguish expression program require more precise c...

Working with goals in youth mental health and substance use service: A review of current practice guidelines and recommendations

Abstract Background Working with goals is a critical yet often overlooked aspect of youth mental health and addictions care, with the potential to strengthen therapeutic relationships, support shared decision‐making, and improve outcomes. Despite its importance, there is no cohes...

Competing methods of divergence time estimation recover diverse evolutionary timescales

Abstract Molecular clocks convert evolutionary distances into geological times to infer time-scaled phylogenies. Methods differ in terms of fossil calibration strategy (node versus tip) and whether they use molecular and/or morphological data, but their relative performance remai...

Why draw lots? Funder motivations for using partial randomisation to allocate research grants.

Background The strengths and weaknesses of peer review in grant allocation continue to be a hot topic, especially with the rise of agentic AI in the formulation of grant applications. Expert judgement is at the heart of research funding processes. However, interventions which mil...

Cranial anatomy of the Middle Eocene Egyptian crocodylian Herugavialis cairensis provides new insights into gavialoid diversity in the Mediterranean region

Abstract Gavialoidea is presently composed of only two extant crocodylian species, the Indian gharial Gavialis gangeticus, and the false gharial Tomistoma schlegelii, both from southeast Asia. However, Gavialoidea displays a rich and near-cosmopolitan diversity in the fossil reco...

Intercultural creativity as criticality; exploring ways of knowing through translanguaging, poetry and dúchas in a borderlands space

Abstract In this article, I draw on translanguaging, poetry as knowing and critical pedagogy alongside Anzaldúan informed decolonial feminist thinking and the precolonial Irish Gaelic concept of dúchas, to inform a transdisciplinary intercultural creativity praxis-paradigm. Accor...

Operationalizing resilience for sustainable infrastructure governance across the life cycle

Abstract Sustainability and resilience expectations for infrastructure are escalating faster than the regulatory frameworks meant to deliver them. This mismatch is most acute for ageing critical infrastructure. Yet, adaptation decisions remain fragmented because resilience and su...

Artificial intelligence cooperation and domestic absorptive capacity: evidence from ASEAN economies

Abstract Cross-border artificial intelligence (AI) cooperation is expanding, but evidence on its effect on domestic technological capability in recipient economies is scarce. Drawing on absorptive capacity theory, we create a composite AI absorptive capacity index for 10 Associat...

Bony labyrinth taxonomic identification and long-term evolution of livestock in the Southwest and Central Asia

Abstract Southwest and Central Asia were pivotal regions for the domestication and dispersal of domestic herbivores. Here we investigate long-term variation in bony labyrinth morphology of domestic bovids (sheep, goats and cattle) across the last 10 000 years. We focused on the o...

Feedback engagement strategies and metrics for consumers in vulnerable circumstances: An empty rapid review and recommendations for further research

Across sectors, there is an increasing recognition of the need to identify and support consumers in vulnerable situations. To assess whether existing support measures are effective and how they might be improved, satisfaction surveys are commonly used. However, low response rates...

A conceptual methodological approach for addressing complex interdisciplinary challenges

Abstract Complex challenges are multi-faceted and, therefore, require the input of knowledge and expertise from different disciplines. However, the prevailing structures of academic institutions tend to be based on specialized disciplinary knowledge and expertise, rather than cro...

Autosomal Recessive RDH12-Leber Congenital Amaurosis Retinal Organoids Suggest Phospholipid Pathway Dysregulation

NADPH-dependent retinol dehydrogenase 12 (RDH12) reduces all-trans-retinal in photoreceptor inner segments to regulate the phototransduction cascade and control the concentration of retinoids in the retina. Variants in RDH12 have been reported to cause an array of retinal disease...

Collective Bargaining and Its Implications for Workers and Employers: An Introduction

Data sharing not applicable to this article as no datasets were generated or analyzed during the current study.

Establishing Stakeholder Priorities for Development of a Multi‐Arm Multi‐Stage Platform Trial in Crohn's Disease

ABSTRACT Background and Aims The expanding range of advanced therapies for Crohn's disease (CD) has increased complexity in treatment selection, particularly in refractory disease. Conventional randomised controlled trials are limited in evaluating multiple treatment strategies e...

What Works Against Populist Rhetoric? The Effects of Counter-Arguments on Democratic Attitudes

Abstract Politicians use populist rhetoric – arguments that portray politics as an enduring conflict between “the good people” and “the evil elites” – to generate support for attacks on constitutional safeguards, the media, and minorities. Yet, little is known about how to counte...