University College London

Effect of human urinary microenvironment and fluid flow on antibiotic and phage therapy efficacy against uropathogenic Escherichia coli

Abstract Urinary tract infection (UTI) remains a major global health burden, with frequent recurrences and rising antimicrobial resistance compromising treatment efficacy. Conventional susceptibility assays often fail to predict clinical outcomes, highlighting the need for more p...

Hypertrophic cardiomyopathy: a genome-wide association meta-analysis and polygenic risk score

ABSTRACT Background Hypertrophic cardiomyopathy (HCM) is a heritable trait with marked variability in expression and outcomes. Our aims were to discover new genetic loci associated with HCM and to test the effect of a new polygenic risk score (PRS) on incidence, phenotype and out...

Comparing outcomes using low‐dose apixaban and anti‐Xa monitoring and vitamin K antagonists in patients with renal replacement therapy

Background Guidelines recommend oral anticoagulation for stroke prevention in atrial fibrillation and secondary prevention of venous thromboembolism. Outside the United States, apixaban is unlicensed for use in patients with end‐stage renal disease (ESRD) receiving renal replacem...

The cost of “what might have been”: false memories for counterfactual actions

Deciding what to do should typically involve considering what could have been done, but in fact was not done. We tested whether such unchosen alternative action paths leave traces in memory. Across two behavioural experiments, participants solved a modified Tower of London (ToL)...

The Internet as Precedent: Architectural Lessons for Federated Computing

This technical note examines the Internet as an architectural precedent for Federated Computing. The analogy lies in preserving local autonomy by making only the conditions required across boundaries explicit. It is not a proposal for a Federated Computing protocol stack, nor a d...

Jung as a philosopher of science: A reformulation of the scientific method through psychology

Recent scholarship has challenged the Freudocentric interpretation of Carl Gustav Jung's psychology and repositioned his work within broader intellectual traditions such as William James's pragmatism. Building on this shift, this paper argues that Jung's Psychological Types (1921...

Oligodendroglial somatic SNCA copy number gains are associated with inclusions and disease onset in multiple system atrophy

Abstract Multiple system atrophy (MSA) is a rapidly progressive synucleinopathy of unknown aetiology with neuronal and oligodendroglial α-synuclein inclusions. We previously reported somatic copy number variants (CNVs), specifically gains of SNCA (encoding α-synuclein) in MSA bra...

The Internet as Precedent: Architectural Lessons for Federated Computing

This technical note examines the Internet as an architectural precedent for Federated Computing. The analogy lies in preserving local autonomy by making only the conditions required across boundaries explicit. It is not a proposal for a Federated Computing protocol stack, nor a d...

Mapping the nuclear environments of extreme coronal line emitting galaxies

Abstract Extreme coronal line emitters (ECLEs) are a rare class of galactic nuclei exhibiting unusually strong high-ionisation forbidden emission lines, and several ECLEs have been linked to tidal disruption events (TDEs). In this work, we compile and analyse optical spectra of 3...

The metacognitive paradox of OCD: confidence is globally reduced but shows increased sensitivity to local evidence

Confidence is a critical metacognitive signal that guides performance. Biases in confidence, such as excessive doubt, are hallmark features of mental health disorders, especially obsessive-compulsive disorder (OCD). Yet, the underlying neurocognitive mechanisms and how they link...

Factors Associated with Persistently Increased IL-6 Levels in People with HIV

BACKGROUND: Individuals with HIV remain at higher risk of non-communicable diseases associated with interleukin-6-specific (IL-6) inflammation compared to the background population. Despite antiretroviral therapy, some individuals exhibit persistent hyperinflammation. We characte...

Primary care quality and secondary healthcare utilisation in patients with multimorbidity: a retrospective cohort study

Background High-quality primary care can improve multimorbidity management but little evidence is available to understand its impact on secondary care use over time. Aim To assess the concurrent and lagged associations between quality of primary care and planned and unplanned sec...

The Worldwide Burden of Parkinson's Disease Is Growing, but Its Incidence Is Not: Lessons from Population‐Based Studies

Data sharing not applicable to this article as no datasets were generated or analysed during the current study. Supporting Information. COI_disclosure. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the aut...

Anxiety, depression, and post-traumatic stress disorder prevalence and comorbidity in humanitarian aid workers exposed to intentional human-made catastrophes: a quantitative research

Research on humanitarian aid workers (HAWs) deployed to intentional human-made catastrophe contexts—such as armed conflicts—is scarce and seldom grounded in systematic theoretical frameworks, leaving psychopathological comorbidity largely unexamined. Guided by the p Factor and Hi...

Preliminary design and energy assessment of an overtopping breakwater for supporting port electrification

The decarbonisation of ports requires the deployment of renewable energy technologies that can be integrated within existing maritime infrastructure while operating reliably under highly variable environmental conditions. In this study, a preliminary model-based energy assessment...

Mentalization and couple relationships: A systematic review of associations and interventions

Abstract Background Mentalization, the ability to understand one's own and another's thoughts and feelings, is considered important for couple functioning. Many couple‐focused interventions aim to improve mentalization, either as the process through which change occurs or as a ce...

Artificial intelligence and ultra-high performance computing methods and experiments for drug discovery: virtual screening, deep learning, molecular dynamics simulations, ADMET modelling, and experimental validation

Recent years have witnessed considerable progress in computer-aided drug discovery, driven by the incorporation of computational technologies within both academic and pharmaceutical environments. This evolution is marked by a significant accumulation of data pertaining to detaile...

Exploring the organisation, operation and inquiries of Centres for Medicines Information: insights from a narrative review and questionnaire

Objectives Centres for Medicines Information (CMIs) are core components in providing evidence-based recommendations to practitioners, thus reducing medication errors. This study examined the organisational and operational features of international CMIs and the types of inquiries...

Applying a systemic approach that extends beyond the brain to Alzheimer’s disease pathogenesis

Traditional dementia research often isolates single aspects, biomarkers or symptoms, overlooking complex interactions shaping disease risk and progression. Lysosomal and mitochondrial dysfunction, reflecting systemic processes, may explain links between Alzheimer’s and metabolic,...

PrEgabalin for Treatment Resistant generalised Anxiety disorder (PETRA): study protocol for a double-blind randomised controlled trial set in the UK

Generalised anxiety disorder (GAD) is common and increasingly recognised in primary care. Although antidepressants and psychological therapies are first-line treatments, many patients have residual anxiety and limited access to therapy. Evidence for effective next-step pharmacolo...