University College London

Spatially Explicit Optimal Decarbonization Pathways for China’s Cement Industry

Abstract Cement production contributes about 8% of global CO2 emissions, but conventional assessments often overlook spatiotemporal heterogeneity in demand, energy resources, infrastructure, and policy constraints. This study develops a high-resolution whole-system optimization f...

COPI Coatomer Regulates Several Steps of HDL Metabolism

Abstract Background Reverse cholesterol transport by high density lipoproteins (HDL) is considered as an anti-atherogenic metabolic pathway. Hepatocytes determine the efficacy of this pathway by the production of apolipoprotein A-I (apoA-I) and its lipidation by ATP binding casse...

Non-solvating additives regulate zinc deposition through anion-gated Stern-layer competition

Abstract While additive-induced modulation of solvation structure has emerged as an effective strategy to enhance the performance of aqueous zinc-ion batteries, the electrochemical mechanisms by which non-solvation additives interact with ion species within the electric double la...

Tear Cytokine Signature in Vernal Keratoconjunctivitis: A Chemokine-Remodeling Axis Associated with Disease Severity

Vernal keratoconjunctivitis (VKC) is a chronic pediatric ocular allergy that can progress from seasonal to persistent inflammation with vision-threatening complications. Although Th2-associated mechanisms have been implicated, the immune correlates of disease severity are not wel...

Deciphering the Roleof Hydrophobic Amino Acid l -Methionine in Tuning CO2 Hydrate Kinetics:Insights from Molecular Dynamics Simulations

Abstract CO2 clathrate hydrate has emerged as a promising medium for carbon sequestration owing to its exceptionally high CO2 storage capacity and intrinsic stability in subsea environments. Sluggish growth kinetics hinder its field application and large-scale deployment. The hyd...

Defining global priorities in hematopoietic transplantation and cellular therapy: a statement paper from EBMT Global ComMittee

Abstract Hematopoietic cell transplantation, cellular and gene therapies, and (CAR)-T cells have revolutionized outcomes in hematologic disorders. However, major disparities persist in their availability, accessibility, and affordability, particularly in low- and middle-income co...

Does the AMPD1 C34T Polymorphism Influence Physical Performance in Elite Athletes?

Background/Objectives: Adenosine monophosphate deaminase deficiency has been implicated in impaired exercise capacity. We examined whether the AMPD1 C34T (rs17602729) genotype was associated with athlete status and performance in distance runners (DR) and rugby union (RU) athlete...

Pedagogy in the speech-gesture couplings of caregivers: Evidence from a corpus-based analysis

In face-to-face communication, representational gestures-imagistically evoking properties of referents-support both language comprehension and development. In adult-adult interaction, representational gestures are systematically produced before the words they are semantically rel...

Data-driven mapping of known and novel fluid biomarker progression profiles in genetic frontotemporal lobar degeneration

Abstract Introduction Recent proteomic studies have identified both established and novel proteins in genetic frontotemporal lobar degeneration (FTLD). However, it remains unclear at what point in the disease these proteins deviate from normal levels and how their trajectories re...

Management of high-risk (B3) breast lesions in symptomatic practice: evidence review and practical recommendations for multidisciplinary care

Borderline breast lesions (B3 lesions, also termed lesions of uncertain malignant potential or high-risk lesions) represent a heterogeneous group of entities associated with variable risks of malignancy. While the management of screen-detected B3 lesions has become increasingly s...

Exploring new measures of accuracy in second language task-based spoken performance

Abstract This article focuses upon the measurement of accuracy in second-language task-based spoken performance, with measures related to unit of analysis, error gravity, and accuracy linked to clause length. Building on established indices, three new measures of accuracy, all li...

The Co-Occurrence of Postural Orthostatic Tachycardia and Functional Neurological Disorder: A Meta-Analysis and Narrative Synthesis

Background: Functional Neurological Disorder (FND) and Postural Orthostatic Tachycardia Syndrome (POTS) are both complex, often debilitating conditions that frequently affect young women and involve high symptom burdens and psychiatric comorbidity. Although clinical overlap betwe...

“The university is the foundation of ethics”: Views of postgraduate students on an MA Education course towards research ethics

Scholarship has emphasised the importance of teaching research ethics within the university context, yet also highlights the challenges involved. Two key barriers may be identified: the conceptualisation of research ethics, and the language found on applications for ethical appro...

Automatic value learning results in counterproductive human behavior

Abstract Humans are adept at accurately estimating the value of available choices from accumulated experience. However, cognitive processing also incorporates irrelevant information during deliberation, undermining decision accuracy. Here, we show that credit assignment operates...

Awake craniotomy for drug-resistant non-oncological epilepsy: a systematic review of feasibility, reported safety, and seizure outcomes

Abstract Introduction Complete resection of the epileptogenic zone offers the best chance of seizure control in patients with drug-resistant epilepsy. However, surgical management remains challenging when the epileptogenic zone is located within or adjacent to eloquent brain regi...

Tell Your Story: Strengthening Scientific Engagement and Welfare Leadership among Animal Technologists

<ns5:p>Background Animal Technologists (ATs) are vital in the scientific community, offering crucial expertise in animal care, welfare, and experimental procedures. As projects become more complex, there is an increasing opportunity for ATs to engage actively in scientific projec...

Where Does the City Grow? Residual Floor Area and the Determinants of Residential (Re)development in São Paulo

Using a novel block-level dataset covering all residential (re)developments in São Paulo, this paper examines why some blocks are (re)developed while others are not. Consistent with development-viability theory, the results show that blocks with greater residual development poten...

Associations Between Dissociation and Childhood Trauma in Borderline Personality Disorder and Affective Disorders: A Network Analytic Approach

ABSTRACT Background Dissociation and childhood trauma are strongly associated with borderline personality disorder (BPD), yet it remains unclear whether this reflects disorder‐specific mechanisms or differences in symptom severity within a shared transdiagnostic structure. Object...

Early Longitudinal Brain Network Changes in Huntington's Disease Before Clinical Motor Onset

Abstract Background Longitudinal studies of seed‐based functional connectivity (SBFC) in young adult Huntington's disease gene‐expanded (HDGE) individuals are rare, and none, to our knowledge, have examined adult cohorts decades from predicted clinical motor diagnosis. Objectives...

Frailty before disease onset: risk of mortality and chronic conditions in disease-free middle-aged adults

Abstract Frailty, defined by multisystem physiological decline and heightened vulnerability to stressors, is typically associated with aging and chronic disease. However, its relevance in apparently healthy individuals remains poorly understood. Identifying frailty in this popula...