University College London

A new megaraptoran dinosaur from the Lower Cretaceous Wessex Formation, UK, and its implications for theropod evolution and biogeography

Abstract Theropod dinosaur remains from the Barremian (Lower Cretaceous) Wessex Formation of the Isle of Wight, UK, are rare and often fragmentary. Here, we present a previously undescribed braincase from this formation that represents a new coelurosaurian, Invictibellatrix amber...

Frequency of plastic occurrence varies across phylogeny but not ecology in seabirds

Seabirds are especially vulnerable to ingesting plastic pollution. However, we have a limited understanding of which traits might increase their risk of plastic ingestion. Here, we use a dataset of seabird plastic occurrence records (93 281 birds from 240 species) to investigate...

Super Warm Early Eocene Simulations With HadGEM3‐GC31‐LL

Abstract The early Eocene Climatic Optimum (EECO; 53.3–49.1 million years ago) represents the period of greatest sustained warmth in the Cenozoic (last 66 million years), with proxy‐data indicating global‐mean temperatures 10–16°C above preindustrial and atmospheric concentration...

Joint Modeling of GD-1 and C-19 as Old Streams

Abstract DESI observational data for the GD-1 and C-19 streams are compared to stream simulations in an evolving multihalo potential of a Milky Way–like galaxy based on a cosmological Milky Way–like simulation. The number of subhalos decreases with time, and the subhalo-stream en...

Clinical Ethics Framework for Last‐Minute Pediatric Refusal of Anesthesia Induction

Induction of anesthesia is one of the most distressing moments for pediatric patients during their perioperative experience. They may consequently refuse induction at the last minute. Anesthesia providers are then placed in a challenging ethical dilemma: they must seek to gain th...

Addition of chemotherapy to radiotherapy promotes progenitor-exhausted CD8⁺ T-cell clonal dominance in head and neck cancer

Abstract Concomitant chemoradiotherapy (CRT) is a standard-of-care treatment for unresectable locally advanced head and neck squamous cell carcinoma (LA-SCCHN), but its immune effects, particularly relative to radiotherapy (RT) alone, remain incompletely understood. Using syngene...

Robust and replicable effects of ageing on resting-state brain electrophysiology measured with MEG

Abstract Non-invasive recordings using brain electrophysiology provide credible insights into decline in neuronal functioning with age. New approaches are required to translate these results into compelling clinical metrics and meet the global challenge of preserving brain health...

Geography in the World Part 4: Towards Latin American Dialogues

ABSTRACT This fourth instalment of Geography in the World (GitW) aims to deepen engagement with geographical knowledge produced outside the Anglophone core—specifically, in Latin America—while reflecting on the practical challenges involved in doing so. The themed intervention co...

Signs of power: giant ficron handaxes may have played a non-utilitarian role in structuring social groups in MIS 9 Britain

Giant ficrons are a rare but recurrent sub-type of Acheulean handaxe, that in Britain are predominantly found in assemblages dating to the MIS 9 interglacial. A variety of theories have aimed to explain the striking size and appearance of giant ficrons as reflecting their use in...

Exploring transcriptomic and genomic latent variable correction approaches in differential expression analysis

Abstract Background Differential expression analysis is a central tool for studying the biological processes altered in human diseases via transcriptomic signatures. However, transcriptomic datasets are systematically confounded by latent variables from two distinct sources: unme...

Sustainable Hydrogel‐Forming Microneedle‐Reservoir Patches for Transdermal Delivery of Hydrophilic Macromolecules: Biopolymers, Green Manufacturing and Translation

ABSTRACT Hydrophilic biomacromolecules, including insulin, peptides, proteins and vaccine antigens, have transformed modern therapeutics, yet their delivery remains dominated by injections because the stratum corneum (SC) severely restricts passive transport of large and polar mo...

MAPT mutations are associated with rDNA transcriptional hyperactivation and nucleolar stress in cellular models

Abstract Tau is traditionally known for its role in microtubule stabilisation, with its pathological aggregation central to tauopathies such as Alzheimer’s disease (AD) and frontotemporal dementia (FTD). Recent evidence suggests that tau also plays important nuclear and nucleolar...

Surgical waiting times in patients with high‐ and low‐risk renal cell carcinoma in England

Objectives To assess to what extent hospitals meet the uniform English National Health Service ‘timely’ treatment standard, what happens after a breach, and determinants of delay for patients with high‐risk renal cell carcinoma (RCC). Patient and Methods Population‐based study us...

Gaps in diabetes care among people living with HIV and hypertension in Botswana: A cross‐sectional analysis of the InterCARE study

Abstract Objectives Data on diabetes screening and monitoring, within HIV care programmes in sub‐Saharan Africa, remain limited. This study describes the quality of diabetes screening and management among people living with HIV with comorbid hypertension receiving care at facilit...

Upper secondary pathways and progression to further study

Upper secondary education is critical in preparing young people for further study. This paper explores how various upper-secondary education pathways influence students' progression to further study. Using linked English administrative data, we compare progression outcomes across...

Polygenic Risk Scores in Alzheimer’s Disease: A Cross-Scale View from Genes to Brain and Behavior

Alzheimer’s disease (AD) is a genetically complex disorder in which inherited susceptibility is distributed across rare high-impact variants, the apolipoprotein E (APOE) locus, and a broad polygenic background of common risk alleles. Polygenic risk scores (PRSs) provide a quantit...

Taking a clinical history in adolescents and adults presenting with seizures or epilepsy

Abstract Despite advances in EEG, neuroimaging, and other diagnostic technologies, a carefully obtained clinical history remains the cornerstone of diagnosis, classification, and treatment planning. However, structured guidance on history‐taking that integrates state‐of‐the‐art e...

Beyond the buzz: analyzing (re)politicization in higher education

Abstract In contemporary higher education studies, ‘politicization’ is frequently invoked when describing state-university tensions, yet the term often serves as a rhetorical device rather than an analytical tool. Drawing on scholarship in political science and sociology, we addr...

Balancing emission reduction and regulatory burden under inspection limits for diesel fleets

Effectively regulating in-use vehicle emissions requires methods that can identify high-impact emitters within heterogeneous vehicle fleets. This study develops a vehicle-level NOx accounting method based on inspection data, converting measured NOx concentrations into estimated e...

Fragile Transnationalism: Rethinking Migrant Transnationalism for a Post-Neoliberal World

In this article, we develop the concept of fragile transnationalism to conceptualize the re-infrastructuring of migrant transnationalism under conditions of post-neoliberal globalization. Since the 2008 Great Recession, the world has witnessed the demise of neoliberal globalizati...