University College London

Secondary patella resurfacing following primary total knee arthroplasty

Aims Our aims were to assess joint-specific outcome (JSO), health-related quality of life (HRQoL), and patient satisfaction following secondary patella resurfacing (SPR), and to define a patient-acceptable symptom state (PASS). Methods This retrospective study was conducted over...

Year-Round High-Resolution Sea Ice Freeboard Retrieval Using ICESat-2 ATL03 Photon Data

Abstract. Arctic sea ice freeboard is critical for estimating ice thickness and characterizing surface morphology, yet it remains poorly constrained, especially during the melt season due to limitations in conventional altimetry products. The ICESat-2 ATL07 product retrieves surf...

COFAS Grade is not Associated with Outcomes following Infinity Total Ankle Arthroplasty: A Multicenter Study with Minimum Five-Year Follow-Up

Background: Total ankle arthroplasty (TAA) is increasingly used for end-stage ankle arthritis, with modern fixed-bearing designs demonstrating improved survivorship. The Canadian Orthopaedic Foot and Ankle Society (COFAS) classification stratifies patients by intra-articular and...

Subicular spatial codes arise from predictive mapping

Abstract The successor representation has emerged as a powerful model for understanding mammalian navigation and memory; explaining the spatial coding properties of hippocampal place cells and entorhinal grid cells. However, the diverse spatial responses of subicular neurons, the...

Non-isothermal vertical distribution functions for the Milky Way

Abstract The vertical structure of our Galaxy has commonly been assumed to follow a pseudo-isothermal distribution. However, there is no a priori reason to expect this form to arise from scattering by giant molecular clouds (GMCs), since GMCs are confined to a narrow layer around...

EP464 - ECE_2010 - Hyperphagia severity in adult patients with Bardet-Biedl Syndrome-a mixed-methods cross-sectional study in the United Kingdom

Background Bardet-Biedl Syndrome (BBS) is a rare genetic disease frequently associated with hyperphagia, an insatiable feeling of hunger, persistent food-seeking behaviours and abnormal food intake. This can have behavioural, emotional, social and health consequences, and may lea...

Ethical compromise, valuing life, and Fechner's Law

Ethical compromise, valuing life, and Fechner's Law Authors: Nigel Harvey, Xiaozhou TanDepartment of Experimental Psychology, University College LondonDOI: https://doi.org/10.5281/zenodo.21940136Licence: CC BY 4.0 What this is Behavioural data from four online experiments on sacr...

Same-sex marriage and migration: politics of belonging, state regulations, and new ways of doing family across borders

The expansion of marriage rights for same-sex couples has coincided in many countries with increasingly restrictive marriage migration policies. These differentiated approaches to marriage – relatively inclusive towards LGBTQI + people and their families, yet increasingly exclusi...

Sleep as a window into thalamocortical pathology: generative modeling implicates NMDA receptor hypofunction in 22q11.2 deletion syndrome

Abstract 22q11.2 deletion syndrome (22q11.2DS) is a strong genetic risk factor for neuropsychiatric conditions, including schizophrenia, yet the underlying synaptic mechanisms remain unclear. Sleep EEG suggests thalamocortical dysfunction, but scalp data alone lack mechanistic re...

Practical tools for using evidence of mechanisms to establish correlations

Abstract. Evidential pluralism is the view according to which we need to think about varieties of evidence. Specifically, to establish causal claims (in medicine and elsewhere), we need evidence of correlation and evidence of mechanisms. The publication of Parkkinen (2018) marked...

Gene Silencer Therapy in Transthyretin Amyloid Cardiomyopathy

Importance: Gene-silencing therapies reduce hepatic transthyretin (TTR) production and have been evaluated in phase 3 trials in TTR amyloid cardiomyopathy (ATTR-CM). However, differences in trial design and background therapies have limited assessment of the overall treatment eff...

Modeling of Diamond Trench Metal Oxide Semiconductor Barrier Schottky Rectifier Based on Dynamic Reverse Bias Simulation Framework

This work presents an electrothermal optimization study of diamond‐based trench metal oxide semiconductor (MOS) barrier Schottky (TMBS) rectifiers using mixed‐mode drift‐diffusion technology computer aided design simulations under quasi‐static and dynamic reverse‐bias conditions....

The Molecular Footprint of Thrombosis: What Does Myocardial Platelet Imaging After STEMI Tell Us?

Heerajnarain Bulluck, MBBS PhD, Derek J Hausenloy, MBChB PhD; The Molecular Footprint of Thrombosis: What Does Myocardial Platelet Imaging After STEMI Tell

Pharmacological Inhibition of Small Extracellular Vesicle Secretion by ALK5i SD‐208 via Lysosomal Rerouting of CD63+ Compartments

ABSTRACT Pharmacological tools to selectively modulate extracellular vesicle (EV) secretion are scarce. Here, we identify the ALK5 (TGF‐β receptor I) inhibitor SD‐208 as a potent suppressor of small EV (sEV) secretion that acts independently of its canonical anti‐fibrotic activit...

Effect of Aficamten on Cardiac Structure and Function in Patients with Symptomatic Nonobstructive Hypertrophic Cardiomyopathy

BACKGROUND: Aficamten significantly improved both functional capacity and patient-reported health status in patients with symptomatic nonobstructive hypertrophic cardiomyopathy in the phase 3 randomized, placebo-controlled ACACIA-HCM trial (Assessment Comparing Aficamten to Place...

Are Group Interventions Effective at Improving Health Outcomes in Culturally And Linguistically Diverse (CALD) Populations With Chronic Conditions? An Umbrella Review

Abstract Culturally and linguistically diverse (CALD) populations experience disproportionate burdens of chronic disease compared to the general population; previous research demonstrated group-based interventions improve health outcomes across various chronic conditions. This um...

Archeological theory and AI: the potential past through agentic systems

Abstract The increasing capabilities of AI in automation and integration within existing methodology present a new opportunity for disciplines to address long-standing theoretical challenges. This is evident in archaeology, where persistent theoretical debates and interpretive va...

Classifications of Substorms With MLT Patterns of SMU‐SML Indices Based on Convection Properties

Abstract During substorms, magnetospheric convection and magnetotail current sheet disturbances are two critical processes, both driving ionospheric electrojets. Dusk‐side SMU and dawn‐side SML (SuperMAG Electrojet indices) enhancements reflect two‐cell convection. Using this rel...

Driven to succeed? Teenagers’ achievement motivation, university aspirations, and performance on high-stakes examinations

Abstract There is growing interest in how young people’s socio-emotional skills, particularly motivation, shape educational outcomes. Yet less is known about how adolescents’ general achievement motivation and their specific aspirations to attend university relate to performance...

National multi-specialty robotic surgery training curriculum and implementation for UK surgical residents: a delphi consensus

Abstract Robotic-assisted surgery is now established across multiple surgical specialties in the United Kingdom, yet training for surgical residents remains variable, resource-dependent, and insufficiently standardised at national level. This study sought multispecialty expert co...