Sun Yat-sen University

A Generalization of Marstrand’s Theorem and Some Geometric Applications

Abstract In this paper we prove using quite elementary methods, with a combinatorial nature, two general results related to Marstrand’s projection theorem in a quite general formulation over metric spaces under a suitable transversality condition (the “projections" are in princip...

Prediagnostic circulating 25-hydroxyvitamin D and prostate cancer-specific survival: a collaborative pooled analysis of 13 prospective studies

Abstract Background Previous research suggests higher risk of prostate cancer diagnosis in men with high vitamin D serology, but there are limited data related to prostate cancer survival. In this study, we examine the associations between prediagnostic circulating levels of 25-h...

MitoGPS: A Mitochondrial DNA G‐Quadruplex‐Targeting Strategy for Tumor‐Preferential Type I Photodynamic Therapy

ABSTRACT Photodynamic therapy (PDT) is a clinically promising, minimally invasive cancer treatment offering precise spatiotemporal control. However, achieving preferential tumor accumulation remains a critical challenge, which limits therapeutic efficacy and induces off‐target to...

Benzo[a]pyrene-induced METTL3 overexpression accelerates renal cell carcinoma progression via m6A modification of LTB4R mRNA and enhanced Treg infiltration

Benzo[ a ]pyrene (BaP) is a widespread environmental pollutant and a representative polycyclic aromatic hydrocarbon with well-established carcinogenic properties. However, the molecular mechanisms through which BaP promotes renal cell carcinoma (RCC) progression, particularly tho...

Using the simple telegraph model to decipher transcriptional burst regulation across genome-wide data.

). Their interdependent dysregulation accelerated HCM. This study establishes the simple telegraph model as a scalable framework linking transcriptional burst dynamics to cell fate and pathology.

Measurement report: Development of a portable peroxy radical measurement system and application for diagnosing local ozone formation and transport

Abstract. Atmospheric total peroxy radicals RO2* (RO2∗=HO2+∑RO2) play central roles in tropospheric chemistry, governing the formation of ozone and secondary aerosols. However, due to their extremely low concentrations and high reactivity, direct observation of RO2* remains chall...

Drosha in mesangial cells regulates glomerular capillary tufts formation through drosha/ribosome/Gata3 axis

Abstract Drosha is a critical regulator of kidney development; its loss or mutation, identified in a subsets of Wilms tumor (WT), a pediatric kidney cancer, leads to nephric cap mesenchyme developmental defects. Here, we investigated the role of Drosha in mesangial cells and its...

Surface-Charge-Regulated MoS2 Membrane for Induced Agglomeration and Efficient Removal of Nanopollutants

Abstract Conventional membranes for nanopollutant removal are constrained by the permeability–selectivity trade-off inherent in size-exclusion mechanisms. Here, we report a surface-charge-regulated MoS2 membrane engineered by anchoring copper nanoparticles and quaternary ammonium...

Complete biosynthesis of the clinical agent escin Ia

Abstract Escin Ia is a barrigenol-type triterpenoid specific to Aesculus seeds and is widely utilized in clinical practice for the treatment of cerebral edema, swelling, and venous insufficiency. Here, we fully elucidated its biosynthetic pathway by identifying ten previously unc...

Machine-learning-based model for predicting surface impedance of microslit panels in grazing flow

Accurately predicting the acoustic properties of noise-reduction materials in real-world, flow-exposed environments remains a significant challenge in engineering. Classical models of microslit panels are unsuited for grazing flow conditions due to complex, nonlinear flow-acousti...

Aquaporin-4-IgG-positive neuromyelitis optica spectrum disorder in an adolescent with inflammatory polyarthritis and Sjögren-related features: a case report

Neuromyelitis optica spectrum disorder (NMOSD) is a severe immune-mediated astrocytopathy most commonly associated with aquaporin-4 immunoglobulin G (AQP4-IgG). Optic neuritis is a common phenotype in pediatric NMOSD, but diagnosis may be delayed when early magnetic resonance ima...

Neuropeptide diversity and evolutionary patterns in crustaceans: insights into adaptations, agonism, and functional importance in organs

<title>Abstract</title> Background Crustaceans exhibit great diversity in anatomical, physiological, and behavioral adaptations, all of which contribute to their evolutionary success, and neuropeptides are important regulators mediating these adaptations. While expansion of certa...

Chitosan Microspheres Incorporating Doxorubicin-Loaded Mesoporous Silica Nanoparticles as a Potential Multifunctional Platform for Postoperative Osteosarcoma Management

Abstract Osteosarcoma remains a major clinical challenge owing to its high recurrence rate, metastatic potential, and the frequent need for postoperative bone reconstruction. Here, we report a multifunctional platform consisting of doxorubicin-loaded mesoporous silica nanoparticl...

Satellite Altimetry Reveals an Eddy Train Along the Ross Sea Shelf Break

Abstract Oceanic circulation along the Antarctic shelf break regulates heat and material exchanges between the continental shelf and the open ocean, playing a crucial role in ice shelf melting and global overturning circulation. However, the circulation remains poorly understood...

Clinicopathological analysis of distant metastasis in dermatofibrosarcoma protuberans: a report of 14 cases

BACKGROUND AND OBJECTIVES: Dermatofibrosarcoma protuberans (DFSP) is a rare sarcoma with a low metastatic rate; however, the prognosis worsens once distant metastasis occurs. We aimed to identify clinicopathological risk factors and molecular features associated with distant meta...

An explainable biomedical foundation model via large-scale concept-enhanced vision–language pretraining

Artificial intelligence for medical imaging is required to be accurate and interpretable to clinicians. However, current multimodal biomedical foundation models often prioritize performance over explainability. Here we present ConceptCLIP, an explainable biomedical foundation mod...

Pamiparib plus surufatinib with ctDNA monitoring in platinum-resistant ovarian cancer after PARP inhibitor progression: a phase Ib/II trial (POST-PARPi)

<title>Abstract</title> Background PARP inhibitors (PARPi) are standard front-line maintenance therapy for advanced ovarian cancer, but the efficacy of PARPi retreatment in later lines remains unclear. This phase Ib/II study evaluated the combination of pamiparib (a PARPi) and su...

An integrated nanopore–microfluidic platform for low-voltage electroporation of delivering self-amplifying RNA into dendritic cells

Efficient delivery of large, negatively charged self-amplifying RNA (saRNA) into dendritic cells (DCs) is critical for next-generation cancer vaccines. However, this remains challenging due to the high sensitivity of DCs to chemical carriers and high-voltage electroporation. In t...

Reconfigurable multibeam engineering of Marangoni convection for programmable optofluidic steering

Optofluidic manipulation provides a powerful route for guiding micro- and nanoparticles, yet conventional light-induced flow systems often suffer from limited controllability, unstable flow patterns, and poor reconfigurability. Here, we demonstrate programmable optofluidic steeri...

A MultitaskLarge Reasoning Model for Molecular Science

Abstract Artificial intelligence in molecular science must move beyond pattern recognition toward chemically valid and interpretable reasoning. We present a task-adaptive large reasoning model that integrates chemical knowledge through a synergistic multispecialist architecture,...