Sichuan University

The cGAS-STING Pathway in Neuroinflammation and Neurological Disease: Mechanisms, Disease Contexts, and Periphery-to-Brain Communication

Neurodegenerative disorders involve a strong inflammatory component, yet the underlying inflammatory mechanisms may be heterogeneous across disease stage, cell type, and systemic context. A key unresolved question is how cellular and systemic stress is converted into sustained ne...

The Multi-Layered Effect of Panaxatriol Saponins in Preventing Diabetic Nephropathy in Mice

Background: Diabetic nephropathy (DN) is a common microvascular complication of diabetes and the leading cause of end-stage renal disease (ESRD). Nearly 40% of people with diabetes will develop DN, and DN accounts for 23% of ESRD cases in China. Dysfunction of the gut-kidney axis...

Curving transparent ceramics via force-driven sintering

Transparent ceramics are critical for advanced optics and armor, but shaping them into highly curved geometries without degrading their optical and mechanical properties remains a formidable challenge. Here, we introduce a force-driven sintering strategy that harnesses force-indu...

Aligning Clinical Needs and AI Capabilities: A Survey on LLMs for Medical Reasoning

Abstract Large language models (LLMs) have emerged as important tools in healthcare, showing growing potential for clinical reasoning and patient care. This survey examines recent progress in medical LLMs, focusing on reasoning applications and requirements. We present a dual-vie...

A New Technique for the Treatment of Ureteral Stricture in Patients with Solitary Kidney

OBJECTIVE: To evaluate the safety and efficacy of the Allium metal ureteral stent (AMUS) in treating ureteral stricture (US) in patients with solitary kidney (SK). PATIENTS AND METHODS: We prospectively collected clinical data from 47 SK patients with US who underwent endoscopic...