Sichuan University

Emerging Hotspots of Cropland Expansion on Steeper Tropical Terrains Intensify Tropical Forest Carbon Loss

Abstract Tropical deforestation driven by agricultural expansion to meet growing food demand poses a rising threat to the global carbon cycle. While previous studies quantified agriculture‐related carbon losses, the role of cropland expansion remains poorly resolved, partly becau...

Albumin-Based Biomarkers and Adverse Outcomes in Coronary Artery Disease: A Systematic Review and Meta-Analysis

Background: Albumin-based biomarkers have emerged as practical tools for prognostic assessment in coronary artery disease (CAD), but their comparative prognostic patterns and potential clinical utility have not been systematically evaluated. Methods: We performed a systematic rev...

POU4F3 variants are prevalent in Chinese patients with autosomal dominant non-syndromic hearing loss and concurrent tinnitus

POU4F3 (DFNA15) is an established causative gene for autosomal dominant non-syndromic hearing loss (ADNSHL); however, its mutational spectrum in the Chinese population remains incompletely characterized. This study aimed to expand the mutational spectrum of POU4F3 in the Chinese...

Emotional labor regulation profiles and predictors among institutional elderly care workers: a cross-sectional study in western China

Emotional labor, the management of feelings and expressions to meet emotional demands, is crucial in the elderly care industry. However, this workforce faces challenges such as high turnover, burnout, and a lack of effective emotional management systems. Meanwhile, research on em...

Diagnosis and Management of Chronic Endometritis: Effects on Postoperative Pregnancy Outcomes in Endometriosis Patients with Proximal Tubal Obstruction Undergoing Hysteroscopic Tubal Catheterization and Laparoscopy

Background: This study aims to investigate the impact of chronic endometritis (CE) diagnosis and treatment on pregnancy outcomes during hysteroscopic fallopian tube catheterization combined with laparoscopy in infertility patients with pelvic endometriosis (EMS) and proximal tuba...

Site-specific programming characterizes dynamic post-translational acetylation of histone H2B lysine 108 in mouse embryonic stem cells

Dynamic histone modifications are critical for regulating stem cell fate. However, generalized strategies for site-specific programming of histone modifications profiling on unperturbed chromatin in embryonic stem cells (ESCs) remain challenging. In this study, we established a g...

EIF1 coordinates transcriptomic and splicing networks associated with cell cycle dysregulation in diabetic retinopathy

Purpose EIF1, an RNA-binding protein implicated in multiple diseases, remains poorly characterized in diabetic retinopathy (DR). This study therefore investigated EIF1 expression and function in an in vitro model of DR pathogenesis. Methods Human retinal pigment epithelial cells...

Functional properties of natural polysaccharides and their applications in meat products: mechanisms and research prospects

Abstract Meat products, as an important component of the human diet, have attracted widespread attention due to their high nutritional value. However, they often face challenges such as allergenicity, short shelf life, and nutritional loss. In recent years, the interaction betwee...

Tail convergence in insurance financial protection: multi-layer performance among hospitalised NCD patients in Southwest China

Introduction China’s multi-layer health insurance system provides financial protection through basic insurance (Urban Employee Basic Medical Insurance [UEBMI] and Urban-Rural Resident Basic Medical Insurance [URRBMI]), catastrophic supplemental coverage, and medical assistance. U...

Material Controls on Landslide-Dam Breach Evolution and Hydrograph Response: A Review

Landslide-dam breaching can generate short-lived, high-magnitude outburst floods, but breach hydrograph prediction remains limited by uncertainty in dam material properties. This review synthesises experimental, field, and modelling evidence through a process chain-linking grain-...

Differentiating Nontuberculous Mycobacterial Lung Disease from Pulmonary Tuberculosis: A Retrospective Study on Clinical Features and a Diagnostic Model

Background: Nontuberculous mycobacterial pulmonary disease (NTM-PD) and pulmonary tuberculosis (PTB) present with similar clinical and radiological features, frequently leading to misdiagnosis. This study aimed to compare NTM-PD with extrapulmonary NTM disease (ENTM) and PTB and...

Association between serum chloride and all-cause mortality in bronchiectasis: a retrospective cohort study and predictive model establishment based on machine learning

Bronchiectasis remains a chronic respiratory condition with substantial disease burden. While chloride dysregulation plays a role in its pathogenesis, the effect of serum chloride on clinical outcomes remains unclear. This study aims to investigate the association between serum c...

Optimal Strain Combinations for Prognostic Prediction in Pulmonary Arterial Hypertension

BACKGROUND: Strain parameters are sensitive indicators of myocardial performance, but the optimal combination for prognostic prediction in pulmonary arterial hypertension remains unclear. METHODS: Patients diagnosed with pulmonary arterial hypertension between June 2013 and June...

52‐week ivarmacitinib in moderate‐to‐severe atopic dermatitis: A phase 3 trial

BACKGROUND: Ivarmacitinib, an oral JAK1 inhibitor, improved efficacy outcomes versus placebo at Week 16 in a phase 3 trial in patients with moderate-to-severe atopic dermatitis (AD). OBJECTIVES: To describe efficacy and safety outcomes through Week 52. METHODS: In this multicentr...

Enhanced Figure‐of‐Merit Energy Harvesting in [001]‐Oriented PMN‐PZT Ceramics Via Synergistic Multi‐Scale Engineering

ABSTRACT Developing piezoelectric materials with a high figure‐of‐merit (FOM = d 33 × g 33 /tan δ ) is crucial for advanced energy‐harvesting technologies. Here, a high FOM is achieved in [001]‐oriented Pb(Mg 1/3 Nb 2/3 )O 3 ‐PbZrO 3 ‐PbTiO 3 (PMN‐PZT) textured ceramics by synerg...

Exploring a Novel Whole-Ovary Decellularization Technique for Developing Suitable Ovarian Bioscaffolds

Artificial ovary construction requires a biocompatible scaffold that mimics native extracellular matrix. This study developed a novel decellularization technique combining physical preconditioning (freeze–thaw cycle, multipoint needling, and 10% NaCl hypertonic solution) with sho...

Sichuan dark tea with a medicine-food-homology formula synergistically alleviates alcohol-associated gut microbiota disturbance, liver steatosis and death in mice

Alcohol-associated liver disease (ALD) is a global health concern. Sichuan dark tea, a popular Chinese beverage, has been reported to have good health effects. In the study, Sichuan dark tea with a medicine-food-homology formula (TEA&MFH) has been created and evaluated for potent...

Extensive systemic thromboembolism in a patient with α-thalassemia after splenectomy: a case report

Pulmonary embolism (PE) is a common respiratory disease that require a thorough etiological workup. However, the pathophysiology of PE in thalassemia patient post-splenectomy can be easily overlooked by pulmonologists. A 38-year-old man, who had been diagnosed with α-thalassemia...

Recent Advances in Non-Viral Vectors for Gene Therapy and Gene Delivery: From Lipid Nanoparticles to Engineered Extracellular Vesicles

Gene therapy and genome editing increasingly depend on the safe, effective, and cell-selective delivery of nucleic acids and protein–nucleic acid complexes. Although viral vectors remain important for applications requiring durable gene expression, non-viral vectors offer advanta...

Impact of pig farming activities on the gut microbiome and resistome of farmers: insights from metagenomics and Escherichia coli genomics

Intensive swine production entails high antimicrobial use and close human–animal microbial exchange, with potential to remodel the human gut ecosystem and promote cross-host antimicrobial resistance (AMR) transmission. To quantify the impact of occupational exposure on the human...