Institution
Sichuan University
Recent research
- Health & Medicine
Rosemary extract (E392) in main Chinese foods and associated health risk
This study assessed the application of rosemary extract (E392) in foods and estimated dietary exposure in China, using a stepwise approach, encompassing theoretical maximum use, enterprise-reported usage, and product-level monitoring. Exposure assessments combined national dietar...
- Health & MedicineOpen access
Abstract Accumulating evidence has suggested that depression is associated with an increased risk of Parkinson’s disease (PD), yet whether pre-clinical depressive symptoms in PD development and the potential mediating effects of metabolomic profiles remain unclear. We aimed to ex...
- Materials & Energy
Weak Acceptors Abnormally Reinforce Urethane Networks while Enabling Glassy-State Healability
Abstract Hydrogen bonds are versatile motifs for designing repairable materials. The current preconception is that while weak hydrogen bonds lead to rapid exchanging dynamics beneficial for healing, they compromise mechanical properties by reducing the overall cohesion of the mat...
- Engineering & Technology
ABSTRACT A fatal issue of zinc‐based electrochemical energy storage (ZEES) is uneven Zn 2+ deposition and rampant dendrite growth on the zinc metal anode, which significantly reduces the lifespan and reliability of ZEES devices. This work reports a cellulose tissue (CT) based sep...
- Health & MedicineOpen access
A randomized, open-label, phase 2 trial assessed fuzuloparib (a PARP inhibitor) plus apatinib (a vascular endothelial growth factor receptor [VEGFR] inhibitor) versus fuzuloparib alone in patients with recurrent ovarian cancer (ROC). Patients with ROC who had failed ≥ 2 lines of...
- Engineering & Technology
Surface‐Fluorinated Conductive Carbon for Coupled Electron/Ion Transport Through the Graphite Anode
ABSTRACT Graphite (Gr) is the dominant anode material for commercial lithium‐ion batteries (LIBs). However, its fast‐charging capability is often constrained by sluggish Li + transport and large interfacial polarization under high current densities. Conventional conductive carbon...
- Health & MedicineOpen access
Adding anti-PD-1 or anti-VEGF therapy to chemotherapy improves survival in patients with advanced gastric cancer, yet outcomes remain poor. This Phase Ib/II trial aimed to evaluate the efficacy and safety of combining sintilimab, the bevacizumab biosimilar IBI305, and CapeOX chem...
- Biology
Abstract In this work, the protective mechanism of exopolysaccharide (EPS) on Lacticaseibacillus rhamnosus during freeze-drying was revealed through physiological, proteomic, and molecular dynamics simulation analyses. Physiological analysis suggested that the addition of EPS cou...
- BiologyOpen access
Mechanistic basis of LolDF-mediated lipoprotein transport in Acinetobacter
Lipoprotein trafficking is essential for Gram-negative bacteria to maintain the outer membrane, a permeability barrier critical for survival and antibiotic resistance. While most bacteria employ the canonical LolCDE transporter, Acinetobacter utilizes a noncanonical LolDF system...
- Engineering & TechnologyOpen access
Abstract Traditional in vivo degradation assessments for resorbable medical devices face challenges due to extreme durations, high costs, and a lack of criteria for reaching tissue-response steady states. This study investigates a 3D-printed PCL/β-TCP bone grafting scaffold by de...
- Engineering & TechnologyOpen access
Fiber-reinforced high-water-resistance concrete backfill (FHWCB) is a rapid-setting cementitious backfill system used for underground support and backfilling, but its stability is strongly affected by mixture water content and fiber dispersion. This study investigated the fresh-s...
- Society & Economics
OBJECTIVE: To explore the effects of coronavirus-specific education and training on nursing interns' self-efficacy, stress levels, and knowledge. METHODS: 74 nursing interns were randomly allocated to either an intervention group (n = 37) or a control group (n = 37). The interven...
- Health & MedicineOpen access
CACA guidelines for the management of adult cancer pain
Abstract Cancer pain, one of the most prevalent and distressing symptoms in cancer patients, is closely associated with cancer diagnosis, therapeutic interventions, quality of life, and survival outcomes. Effective cancer pain management requires multidisciplinary collaborative a...
- Physics & Space
Abstract A series of LixAg1–xGaTe2 (x = 0.1 ∼ 0.6) solid-solution single crystals was grown by the Bridgman method. The inherent instability of LiGaTe2 and the narrow bandgap of AgGaTe2 are simultaneously surmounted, and the structure and nonlinear optical performance are thereby...
- Biology
Advancesand Challengesin Nanodelivery Systems forRNA Vaccines
Abstract RNA vaccines have become a transformative technology in infectious disease prevention and cancer treatment, thanks to their rapid development, high immunogenicity, and scalability in production. However, the clinical application of RNA vaccines faces significant challeng...
- Health & MedicineOpen access
To investigate epidemiological trends of cervicofacial space infections in Western China, including pathogen distribution, antimicrobial resistance, and the impact of the COVID-19 pandemic on pathogen susceptibility and patient outcomes. Clinical data from 542 hospitalized patien...
- Climate & EnvironmentOpen access
The accumulation of pyrite tailings (PT) poses severe environmental threats, yet its potential as a secondary resource for the construction sector remains underexplored. This study presents a preliminary investigation of raw PT as a partial substitute for fine aggregate in mortar...
- Biology
Secondary narrow nostril deformity after unilateral cleft lip repair remains a stubborn clinical challenge, with an incidence of approximately 84%. It compromises both nasal airway function and facial esthetics. The etiology is multifactorial, involving congenital tissue deficien...
- Health & MedicineOpen access
EPI-Sense: an integrated hemodynamic sensing and analysis system for early pressure injury warning
Pressure injury poses a critical challenge in geriatric care. Current computer-aided diagnosis is limited by an exclusive reliance on surface texture, neglecting subcutaneous hemodynamics essential for distinguishing Reactive Hyperemia from Stage 1 PI and detecting Deep Tissue Pr...
- Health & MedicineOpen access
Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...