Sichuan University

Social determinants of health and lifestyle in the progression of degenerative bone and joint diseases: a prospective multi-state analysis

Abstract Aims The role of social determinants of health (SDOH) in the progression of degenerative bone and joint diseases (DBJDs) - from initial onset to multimorbidity and mortality - remains unclear. We aimed to assess the associations of SDOH with DBJDs progression, examine th...

Cross-cultural adaptation and psychometric assessment of the Chinese version of the University of Wisconsin Running Injury and Recovery Index in runners

The University of Wisconsin Running Injury and Recovery Index (UWRI) is a nine-item patient-reported outcome measure assessing self-perceived running ability following running-related injury (RRI). This study aimed to translate and cross-culturally adapt the UWRI into Chinese and...

Quantitative Evaluation of Cervical Spine Morphometry: Zero Echo Time MRI Versus Multislice CT

BACKGROUND: For preoperative cervical assessment, both CT and MRI are often required for bony and soft-tissue evaluation, yet CT entails radiation and MRI poorly depicts cortical bone. ZTE offers CT-like contrast in one examination, but whether it correlates with CT for quantitat...

Engineered desialylated platelet membrane camouflaged liposomes for the regulation of kupffer cells and hepatic stellate cells in treatment of liver fibrosis

The intercellular crosstalk and reciprocal activation between Kupffer cells (KCs) and hepatic stellate cells (HSCs) are critical drivers of liver fibrosis progression. Nonetheless, the co-regulation of KCs and HSCs is hindered by their distinct anatomical locations and the pathol...

Decoding how macronutrients influence depressive symptoms: Combined insights from regression, nonlinear modeling, and machine learning: a cross-sectional study using NHANES data

Dietary management is an essential component of comprehensive depression care;however, studies simultaneously evaluating multiple macronutrients and their associations with depressive symptoms are limited. Data from National Health and Nutrition Examination Survey 2005 to 2023 we...

Preparation andEvaluation of Biopolysaccharide-BasedTemperature-Resistant Drilling Fluid Additives

Abstract Xanthan gum (XG), valued for its environmental friendliness and multifunctionality, has been extensively utilized in drilling fluids. However, its inadequate thermal stability at elevated bottomhole temperatures encountered in deep drilling operations has constrained its...

Association Between Psoriasis and Overactive Bladder Among US Adults: A Study Based on 2005–2006 and 2009–2014 National Health and Nutrition Examination Survey

BACKGROUND: Both psoriasis and overactive bladder (OAB) are considered systemic conditions that share many inflammatory or immune pathways in the pathogenesis. One previous study found patients with psoriatic arthritis (PsA) reported significantly higher bladder autonomic dysfunc...

Verbal and nonverbal cues in influencer performance: a deep learning perspective on livestreaming e-commerce

Purpose Grounded in the elaboration likelihood model (ELM), this study aims to examine how influencer performance shapes sales outcomes in livestreaming e-commerce through the concurrent activation of the central route (verbal cues) and peripheral route (nonverbal cues), and how...

U-Shaped Association Between Left Ventricular Dimension and Mortality in Patients With Heart Failure

Importance Left ventricular structural assessment is fundamental in heart failure (HF). However, the independent prognostic value of left ventricular size beyond its association with ejection fraction remains poorly defined in real-world, large-scale populations. Objective To inv...

Aminosugar-FunctionalizedMicrospheres with SuperiorBoron Selectivity and Reusability: Synthesis, Performance, and ChelationMechanism

Abstract Traditional adsorbents often face challenges such as low adsorption capacity, poor selectivity, difficulties in regeneration, and limited stability, rendering them inadequate for boron-containing wastewater treatment. In this study, glycerol methacrylate (GMA) is graft-c...

Iatrogenic botulism induced by cosmetic injection requiring mechanical ventilation: clinical characteristics and outcomes

Introduction Cosmetic iatrogenic botulism is increasingly reported, but data on severe cases complicated by neuromuscular respiratory failure requiring mechanical ventilation remain limited. This study aims to characterize clinical features, treatment, and outcomes of such cases....

A Clustering-Based Multi-Task Balancing Method for Depot Optimization in Single-Depot Multiple Traveling Salesman Problems

In the single-depot multi-traveling salesman problem, traditional depot location methods often overlook task balance among traveling salesmen, leading to excessive load on certain units and compromising overall operational efficiency. To address this issue, this paper proposes an...

Assembly of Bioactive Superstructures via Metal–Phenolic Complexation for Blood Purification

ABSTRACT Hyperbilirubinemia, which stems from bilirubin accumulation caused by liver failure, can lead to jaundice, multi‐organ damage, and mortality. Hemoperfusion is the most effective detoxification approach, and its efficacy critically depends on the adsorbent system. However...

Discovery, Synthesis,and Biological Evaluation of1,3,4,5-Tetrahydro-6 H -pyrano[4,3- c ]isoquinolin-6-one Derivatives as Novel and Highly SelectivePARP1 Inhibitors

Abstract Developing highly selective PARP1 inhibitors is a promising strategy to improve the therapeutic window compared with dual PARP1/2 inhibitors. Through structure-guided design and optimization, we developed (R)-A17, a novel, highly selective PARP1 inhibitor featuring a uni...

Catalytic Regulation of Reaction Networks in High-Concentration 5-Hydroxylmethylfurfural Oxidation

Abstract The selective oxidation of 5-hydroxymethylfurfural (HMF) to 2,5-furandicarboxylic acid (FDCA) is a key catalytic transformation for the production of renewable polymers. Although near-quantitative FDCA yields can be achieved under dilute conditions, increasing substrate...

Genetic Diversity and Phylogeny of Chilli Veinal Mottle Virus in Yunnan Tobacco-Planting Regions Based on the CP Gene

Chilli veinal mottle virus (ChiVMV, Potyvirus capsivenamaculae) can infect various Solanaceae crops, causing a decrease in yield and quality. In recent years, ChiVMV has become one of the most prevalent viruses affecting tobacco production, but its diversity and genetic structure...

Robot‐assisted Parotidectomy: Improved Clinical and Patient‐Reported Outcomes

OBJECTIVE: To compare perioperative outcomes, postoperative safety, and patient-reported outcomes among conventional, endoscopic, and robot-assisted parotidectomy for primary benign parotid tumors. STUDY DESIGN: Retrospective comparative study. SETTING: Tertiary academic institut...

A Tough, Room‐Temperature Curable and Economical Structural Adhesive Inspired by Luminescent Squid Skin

ABSTRACT Structural adhesives play a crucial role in achieving robust and intelligent bonding across diverse scenarios. However, the multi‐scenario bonding reliability and functionality of traditional epoxy adhesives remain constrained by their inherent brittleness, stress sensit...

Organizing Large GTPase Atlastin‐Mediated Membrane Fusion by Programmable DNA Origami Platforms

ABSTRACT In eukaryotic cells, the endoplasmic reticulum (ER) utilizes membrane fusion to form interconnected networks. GTP hydrolysis‐triggered conformational changes in ER‐anchored atlastins (ATLs) have been shown to be responsible for this process, which is facilitated by the a...

RNF213 in Panvascular Disease: A Molecular Hub Linking Genetic Susceptibility to Systemic Vasculopathy

Panvascular diseases, characterized by systemic vascular dysfunction across multiple organ systems, represent a complex interplay of genetic susceptibility and environmental triggers. Ring Finger Protein 213 (RNF213), initially identified as the principal susceptibility gene for...