Sichuan University

Numerical and Physical-Model Investigation of Landslide-Generated Surge Waves from a Localized Unstable Zone in the Yangqu Canyon Reservoir: Wave Generation and Propagation

Surge waves generated by rapid landslide entry into canyon reservoirs can threaten near-dam hydraulic structures. This study examines a representative post-failure hydrodynamic scenario for the localized unstable Zone B of the No. 1 deformation body slope near Yangqu Hydropower S...

Precision Dosing for Pediatric Growth Hormone Deficiency With Daily and Weekly Growth Hormone

ABSTRACT Pediatric growth hormone deficiency (GHD) typically requires daily injections of recombinant human growth hormone (rhGH). Long‐acting PEGylated recombinant human growth hormone (PEG‐rhGH) formulations have been developed to reduce injection frequency and improve adherenc...

Bionic Protein Bond Constraint‐Reinforced and Enriched Multifunctional Hydrogel Coating for Invasive Medical Devices

ABSTRACT Dual‐targeted strategies addressing both infection and trauma from invasive devices are imperative. Herein, we developed a bionic protein bond constraint strategy to construct multifunctional quaternary ammonium hydrogel coatings (BEAC). Inspired by the secondary bonds s...

HIRA loss is frequent but not universal in human fumarate hydratase-deficient renal cell carcinoma and defines divergent oncogenic programs

Fumarate hydratase-deficient renal cell carcinoma (FH-dRCC) is a rare and highly aggressive malignancy driven by fumarate accumulation and widespread epigenetic reprogramming. Although Valcarcel-Jimenez et al. have demonstrated that loss of the histone chaperone Hira is a critica...

Bone Marrow‐Derived Cell Therapy Plus Core Decompression Enhanced Efficacy Compared With Core Decompression Alone in Treating Osteonecrosis of the Femoral Head: A Systematic Review and Meta‐analysis of Randomized Controlled Trials

PURPOSE: To systematically determine whether bone marrow-derived cell therapy combined with core decompression could result in better improvements in pain relief, function, and radiographic progression, higher survival of hip joints, and an equivalent rate of adverse events than...

Deconstructing tourist experiences in China's traditional villages: a cognitive–affective–conative perspective

Purpose While traditional village tourism is rapidly flourishing in China, scholarly research on tourists' experiences within these destinations remains limited. This study explores the tourist experience in China's traditional villages. Design/methodology/approach Using the cogn...

Sitting Time and Physical Activity Correlate With Asthma Exacerbations in Adults: A Cross‐Sectional Study From the Australasian Severe Asthma Network

Summary Lower levels of sitting time were associated with a lower risk of severe asthma exacerbations in adults. High levels of physical activity eliminated the detrimental association of sitting time with severe asthma exacerbations in adults.

Anchored Oxygen‐Release‐Suppression Phase Stabilizing High‐Voltage Ni‐Rich Cathode Materials

ABSTRACT The Ni‐rich LiNi x Co y Mn 1−x−y O 2 (x ≥ 0.9) cathode materials (NCMs) have been considered promising for next‐generation Li‐ion batteries owing to their high‐energy density. However, their practical application is hindered by gas evolution and rapid capacity degradatio...

Efficient Colon Cancer Immunogene Therapy by Hydrogel Ball Loaded With Two Types of Cell Membrane‐Coated Nanoparticles

ABSTRACT Biomimetic technology has high potential for enhancing cancer immunogene therapy. Cell membrane‐coated nanoparticles (CMNPs) obtain extra targeting, recognition, and signaling transduction functions. However, a single kind of CMNPs is limited when facing complicated tumo...

Cobalt‐Catalyzed Enantioselective Vinyl Carbene Annulation: A Versatile Platform for Semisaturated Heterocycles

ABSTRACT Semisaturated heterocycles are privileged scaffolds in natural products and pharmaceuticals, yet a general and versatile catalytic strategy to access these chiral architectures remains a formidable challenge. Herein, we report a unified synthetic platform utilizing the e...

P1.080. Dynamic ctDNA Profiling Predicts Pathological Complete Response and Identifies Pseudoprogression in ESCC Receiving Neoadjuvant Immunochemotherapy

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background The integration of anti-PD-1 antibody therapy with chemotherapy has shown promising results in the neoadjuvant treatment of locally advanced esophageal squamous cell carcinoma. Conventional imaging m...

3D-printed biochemical–biomechanical gradient scaffolds from high internal phase Pickering emulsion with dual gelatin-modulated gelling kinetics for enhanced osteochondral regeneration

Three-dimensional (3D) printing enables the precise design of biomaterials at predefined spatial locations, representing a promising strategy for constructing highly organized osteochondral tissue with multiple morphogen gradients. However, most current 3D printing strategies lim...

Immune-inflammatory biomarkers for in-hospital mortality risk stratification in older patients with sepsis: a multicentre leave-one-hospital-out validation study

Older adults with sepsis have high mortality, but whether circulating immune-inflammatory biomarkers improve prediction beyond routine clinical information across hospitals is uncertain. We analysed 816 patients aged ≥ 60 years from a prospectively assembled multicentre cohort at...

Minimally invasive surgery vs radical open surgery for perihilar cholangiocarcinoma: a systematic review and network meta-analysis

This network meta-analysis (NMA) analyses the latest evidence to evaluate perioperative and postoperative outcomes between minimally invasive surgery (MIS), including robot-assisted (RA) and laparoscopic (LA) approaches, versus open (OA) radical surgery for hilar cholangiocarcino...

Cobalt‐Catalyzed Enantioselective Vinyl Carbene Annulation: A Versatile Platform for Semisaturated Heterocycles

ABSTRACT Semisaturated heterocycles are privileged scaffolds in natural products and pharmaceuticals, yet a general and versatile catalytic strategy to access these chiral architectures remains a formidable challenge. Herein, we report a unified synthetic platform utilizing the e...

P1.003. Causal Immune-Inflammation Mapping of the GERD-Barrett-Adenocarcinoma Cascade Identifies FGF19-HLA-DR+ T-Cell Axis Driving Esophagogastric Junction Metaplasia

Abstract Topic Benign Disease: Barrett’s Esophagus: Pathology and Pathophysiology; Non-invasive Neoplasia Background Gastroesophageal reflux disease (GERD), Barrett’s esophagus (BE), and esophageal adenocarcinoma (EAC) form a recognized pathological continuum, but the causal immu...

Ionic Liquid-Mediated Structure-Engineered Cellulose-Based Ionogel with Ion-Electron Cotransport for Boosted Thermoelectric Conversion

Abstract Low-grade heat (<373 K) remains an underutilized energy source due to inefficient conversion technologies. While ionic thermoelectric (i-TE) materials show promise for direct thermal-to-electrical energy conversion, simultaneously optimizing the conductivity and Seebeck...

Recent Increaseof Greenhouse Gas Emissions from Cryosphere-InfluencedReservoirs under Climate Change

Abstract Global warming leads to cryosphere degradation, transferring large amounts of terrestrial carbon and nitrogen to reservoirs, which may accelerate the release of greenhouse gases (GHGs) to the atmosphere. However, the spatial dynamics and decadal trends of GHG emissions f...

Latent profile analysis of social alienation and its influencing factors in patients undergoing maintenance hemodialysis

Social alienation severely impairs the mental health and quality of life of patients undergoing maintenance hemodialysis (MHD). However, most studies conducted have been variable-centered, group-level analyses, which cannot capture inherent heterogeneity in social alienation, hin...

Colonial history shapes the pathways toward energy independence driven by renewable energy innovation

Energy independence is a cornerstone of national sovereignty, increasingly dependent on renewable energy development. Yet structural inequalities rooted in colonial history, institutional path dependence, and global innovation barriers shape the effectiveness of technology-enable...